CAS: 60057-62-7; 2-Hydroxy-2-(4-Isobutylphenyl)Propanoic Acid

上下游产品

chloroform 1-(4-isobutyl-phenyl)-ethanone trichlorofluoromethane ethyl 2-(4-isobutylphenyl)-2-hydroxypropanoateibuprofen 2-(4-isobutylphenyl)acrylic acid 1-(4-isobutyl-phenyl)-ethanone

异丁基苯置于三氯化铝,水,Potassium Carbonate,Magnesium体系中,用 乙醇,1,2-二氯乙烷 作为反应溶剂,化学反应 16.0H,反应生成 外消旋alpha-羟基布洛芬
参考文献:Quantitative Relations Between Structure And Activation Of Fibrinolysis In Selected Series Of Arylaliphatic Acids
标题:Quantitative Relations Between Structure And Activation Of Fibrinolysis In Selected Series Of Arylaliphatic Acids
摘要:这篇论文描述了芳基醋酮ix与三乙基磷酸乙酯反应,反应生成4-芳基-3-甲基-2-丁烯酸酯x和4-芳基-3-甲基-3-丁烯酸酯x'.它们的水解产生了异构酸i和i'的混合物,其组成通过1H NMR谱进行了研究.还制备了3-甲基-3-苯基-2-丙烯酸ii,2-芳基-2-羟基丙酸iv和取代的α-苄氧基苯乙酸v.这些酸,连同芳基氧代脂肪酸iii,被研究其在激活纤溶作用中的功效.所研究的酸的亲脂性通过分配系数(酸ia和iia)或通过分配色谱法在正辛醇-水(ph 3.5)体系中确定.实验值log P与从片段常数f和参数π计算得到的值进行了比较.对于酸v,亲脂性的降低类似于观测到的芳基氧代脂肪酸.对于酸i,I'和ii,纤溶能力与亲脂性成正比.尽管我们评估了酸i和i'的混合物的纤溶能力,但线性关系与先前得出的一组芳基脂肪酸的结果一致.酸iii和iv中连接链上的功能基团对纤溶能力有负面影响.纤溶能力的降低可能是由于功能基团能够形成氢键.
DOI:10.1135/cccc19840122

专利信息

专利号:US-5750764-A
优先权日:1995-11-17
标题 :Synthesis and resolution of propionic acid derivatives
发明人：MARAIS STEPHANUS FRANCOIS; KHAILE THEBEEAPELO JOHN; NJAMELA OWEN LUNGILE; BRAITHWAITE DANA HELEN; DAVIDSON DEBORAH NICOLE; JUNGMANN CHRISTA MARIA; PARKINSON CHRISTOPHER JOHN; GARDINER NEIL STOCKENSTROM; STEENKAMP LUCIA HENDRINA; VAN EEDEN SKEIN ETIENNE
权利人:AECI LTD
摘要:A process for the production of disubstituted propionic acid derivatives which are intermediates in the synthesis of α-arylpropionic acids such as naproxen, involves the reaction of a naphthalene derivative such as 2-methoxynaphthalene, with an alkylating agent such as an alkyl pyruvate in the presence of a catalyst, and then dehydrating and hydrogenolising, or directly hydrogenolising, or derivatising and then hydrogenolising the product thereof, to produce the desired compound.

专利号:WO-9719048-A1
优先权日:1995-11-17
标 题:Synthesis of propionic acid derivatives