专利号:US-4408059-A 优先权日:1981-12-04 标 题 :Spiroketals useful as intermediates in the synthesis of milbemycin and avermectin macrolides 发明人:SMITH III AMOS B; SCHOW STEVEN R 权利人:UNIVERSITY PATENTS INC 摘要:Milbemycin and avermectin macrolides are synthesized by the cyclized linking of separately synthesized northern and southern hemisphere intermediates. The northern hemisphere intermediate is a spiroketal alkenyl aldehyde, and the southern hemisphere intermediate is an aryl alkenyl phosphine oxide anion.
专利号:CN-118146185-A 优先权日:2024-03-07 标 题 :Palladium-catalyzed synthesis of isocoumarin derivative containing aldehyde group and synthesis method
专利号:US-9820979-B2 优先权日:2011-07-13 标 题:FXR (NR1H4) binding and activity modulating compounds 发明人:KINZEL OLAF; STEENECK CHRISTOPH; KREMOSER CLAUS 权利人:GILEAD SCIENCES INC 摘要:The present invention relates to compounds which bind to the NR1H4 receptor (FXR) and act as agonists of FXR. The invention further relates to the use of the compounds for the preparation of a medicament for the treatment of diseases and/or conditions through binding of said nuclear receptor by said compounds and to a process for the synthesis of said compounds.
专利号:WO-8301953-A1 优先权日:1981-12-04 标 题 :Synthesis of milbemycin and avermectin macrolides
专利号:CA-1196630-A 优先权日:1981-12-04 标题 :Synthesis of milbemycin and avermectin macrolides
专利号:EP-0095495-A1 优先权日:1981-12-04 标 题:Synthesis of milbemycin and avermectin macrolides