顺式-1,4-二氯-2-丁烯置于sodium Hydride体系中,用 N,N-二甲基甲酰胺 作为反应溶剂,化学反应 20.42H,以51%的收率获得产物n-Boc-3-吡咯啉 参考文献:Substituted 3-Amino-4-Hydroxy Pyrrolidines Compounds,Their Preparation And Use As Medicaments 标题:Substituted 3-Amino-4-Hydroxy Pyrrolidines Compounds,Their Preparation And Use As Medicaments 摘要:本发明涉及通式(i)的取代吡咯烷化合物,其制备方法,包含这些化合物的药物以及它们在制备用于治疗人类和动物的药物中的应用.
专利号:US-6417363-B1 优先权日:1997-12-04 标题 :Heterocyclyl ligand containing ruthenium and osmium catalysts 发明人:VAN DER SCHAAF PAUL ADRIAAN; MUEHLEBACH ANDREAS; HAFNER ANDREAS; KOLLY ROMAN 权利人:CIBA SC HOLDING AG 摘要:Penta- and hexa-coordinated, bridged ruthenium and osmium catalysts of the formulawherein Me is ruthenium or osmium; L1 and L2 are neutral ligands having electron donor properties;X is an anionic ligand; Y is oxygen or sulphur; A is a direct bond, C1-C4alkylene or C2-C4alkylidene;Z is a direct bond, oxygen, sulphur or the groupswherein R1 and R2 are hydrogen or hydrocarbon radicals; their preparation and their us in the synthesis of polymers, in the ring-closure metathesis of diolefins, in the cross metathesis of olefins and in the isomerisation of olefins are disclosed.
专利号:JP-2025507157-A 优先权日:2022-03-21 标题 :Continuous synthesis of N-Boc-2,5-dihydro-1H-pyrrole
专利号:CN-113185479-A 优先权日:2021-04-27 标 题 :Application of Organic Amine Additives in the Synthesis of Fluorescent Dye Intermediates by Olefin Hydroformylation
专利号:CN-114349676-A 优先权日:2022-03-21 标题:A method for the continuous synthesis of N-Boc-2,5-dihydropyrrole
专利号:CN-118084767-A 优先权日:2024-04-02 标 题:Synthesis method of exo-6-fluoromethyl-3-azabicyclo [3,1,0] hexane hydrochloride and derivative thereof
专利号:CN-118005551-A 优先权日:2023-12-29 标题:Synthesis process of natural product Talaroconvolutin A with anticancer activity
摘要:Ipaktschi, J.; Saidi, M. R., Science of Synthesis Knowledge Updates, (2011) 3, 402. 摘要:Coeffard, V.; Guiry, P. J., Science of Synthesis: Cross Coupling and Heck-Type Reactions, (2012) 3, 312. 摘要:Godard, C.; Perandones, B. F.; Claver, C., Science of Synthesis: C-1 Building Blocks in Organic Synthesis, (2013) 1, 97. 摘要:Schmid, T. E.; Crévisy, C.; Baslé, O.; Mauduit, M., Science of Synthesis: N-Heterocyclic Carbenes in Catalytic Organic Synthesis, (2016) 2, 354.