CAS: 776-99-8; 1-(3,4-Dimethoxyphenyl)Propan-2-One

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CAS号93-15-2 甲基丁香酚, 甲基丁子香酚 | CAS号122-47-4 3,4-二甲氧基-beta-甲... | CAS号75-16-1 甲基溴化镁 | CAS号120-14-9 藜芦醛； 3,4-二甲氧基苯甲醛 | CAS号84784-33-8 α-(3,4-dimethox... | CAS号100613-28-3 3-Oxo-4-(3,4-di... | CAS号2859-78-1 3,4-二甲氧基溴苯 | CAS号67-64-1 丙酮 | CAS号27602-80-8 23EPOXYEUGENOLM... | CAS号19578-92-8 1-(3,4-二甲氧基苯基)丙-2-醇 | CAS号93-07-2 藜芦酸 | CAS号22345-47-7 托非索泮 | CAS号892-02-4 5-(3,4-二甲氧基苄基)-... | CAS号2883-98-9 α-细辛脑 | CAS号93-03-8 藜芦醇 | CAS号24150-24-1 teramepr°Col | CAS号161121-02-4 (S)-1-(3,4-二甲氧基... | CAS号118128-82-8 2-[(3,4-dimetho... | CAS号109397-53-7 6,7-dimethoxy-4...

3,4-二甲氧基苯乙腈置于硫酸,Sodium Ethanolate体系中,化学反应生成 3,4-二甲氧基苯丙酮
参考文献:α-Methyl α-Amino Acids. Ii.1 Derivatives Of Dl-Phenylalanine
标题:α-Methyl α-Amino Acids. Ii.1 Derivatives Of Dl-Phenylalanine
摘要:
DOI:10.1021/ja01608A046

专利信息

专利号:US-7928223-B2
优先权日:2008-06-20
标题:Process for the synthesis of 7,8-dimethoxy-1,3-dihydro-2H-3-benzazepin-2-one, and application in the synthesis of ivabradine and addition salts thereof with a pharmaceutically acceptable acid
发明人：LERESTIF JEAN-MICHEL; LECOUVE JEAN-PIERRE; BRIGOT DANIEL
权利人:SERVIER LAB
摘要:Process for the synthesis of the compound of formula (I): n n n n n n n n n n Application in the synthesis of ivabradine, addition salts thereof with a pharmaceutically acceptable acid and hydrates thereof.

专利号:US-5861532-A
优先权日:1997-03-04
标 题:Solid-phase synthesis of N-alkyl amides
发明人：BROWN EDWARD G; NUSS JOHN M
权利人:CHIRON CORP
摘要:Methods for solid phase synthesis of N-alkyl amides comprise reductive amination of carbonyl compounds using a reducing agent and an amine-containing linker bound to a solid support. The methods afford high yields of linker-bound, monoalkylated amines, and subsequent coupling with acid derivatives provide derivatized N-substituted amides in excellent yields after cleavage from the solid-phase. Compositions useful in solid phase synthesis are also described.

专利号:US-4000197-A
优先权日:1973-07-23
标 题 :Asymmetric synthesis of phenylisopropylamines
发明人：BARFKNECHT CHARLES F; NICHOLS DAVID E
权利人:UNIV IOWA RES FOUND
摘要:The synthesis of enantiomers of a series of methoxy- and alkyl- substituted phenylisopropylamines is described. The synthesis comprises reducing the imines, formed by the reaction of appropriate phenylacetones with either (+)- or (-)-α-methylbenzylamine, by low-pressure reduction techniques, and subsequently subjecting the optically active N-(α-phenethyl)phenylisopropylamine derivative to hydrogenolysis. The hydrogenolysis products are characterized by enantiomeric purities in the range of 96 - 99%. Yields of products are approximately 60%.

专利号:WO-2005108592-A1
优先权日:2004-05-12
标题:Process for production of optically active propargyl alcohol
发明人：YAMAMOTO HIROAKI; KUDOH MASATAKE; HAYASHI MOTOKO
权利人:TAISHO PHARMACEUTICAL CO LTD; YAMAMOTO HIROAKI; KUDOH MASATAKE; HAYASHI MOTOKO
摘要:The invention provides a process for the production of optically active propargyl alcohol useful as an intermediate in the synthesis of drugs. According to the invention, optically active propargyl alcohol is produced by asymmetric reduction of propargyl ketone with a secondary alcohol dehydrogenase or a carbonyl reductase.

专利号:US-5468865-A
优先权日:1994-05-03
标题 :Stereopreferential synthesis of 3-(1-phenylprop-2-yl)-5-phenyloxazolidinones
发明人：RAJU MUPPALA S; KHETANI VIKRAM
权利人:CELGENE CORP
摘要:The (R,R)-diastereoisomer of oxazolidin-2-ones, which are chemical intermediates for the preparation therapeutic agents useful in the treatment of diabetes and hyperglycemia, are prepared substantially free of isomeric forms through reduction of an acid addition salt of an (R)-N-protected-N-phenylcarboxymethyl-1-phenylprop-2-ylamine to form a secondary alcohol of predominantly the (R,R) chiral form in preference to others, removal of the protecting group to form a secondary amine, and allowing the secondary amine to react with a source of carbonyl groups. A typical embodiment involves the preparation of (R,R)-3-[1-(3,4-dimethoxyphenyl)prop-2-yl]-5-(3-chlorophenyl)oxazolidin-2-one in which both the chemical purity and optical purity are in excess of 99%.

专利号:US-6673543-B2
优先权日:2000-04-05
标 题:Solid phase synthesis of LXR ligands
发明人：MEDINA JULIO; IMAZAKI NAONORI
权利人:TULARIK INC; SUMITOMO PHARMA
摘要:The invention provides solid support synthetic methods for producing combinatorial libraries of modulators of LXRs. The combinatorial libraries thus produced are useful both as diagnostic indicators of LXRα function and as pharmacologically active agents. The combinatorial libraries find particular use in the treatment of disease states associated with cholesterol metabolism, particularly atherosclerosis and hypercholesterolemia.