CAS: 80223-99-0; 5-(2-((2-(2-Ethoxyphenoxy)Ethyl)Amino)Propyl)-2-Methoxybenzenesulfonamide Hydrochloride

该化合物是一种化学化合物,其特征是其磺酰胺结构,通常具有抗菌特性.该化合物具有复杂的分子结构,包括苯乙酰胺,一种乙氧氧基混合物组和一个丙基胺侧链,有助于其潜在的生物活动.盐化物的存在表明这是一种盐形式,常常会增加水中的溶性,并可能影响其药用植物特性.该甲基氧化合物还可能影响该化合物的再活动及其与生物目标的相互作用.一般而言,这种性质的化合物的治疗用途受到调查,特别是在医药化学和药物开发领域.然而,具体的生物活动,毒性和药理学特征需要进一步的经验研究,以阐明其全部潜力和安全性.

英文名称5-(2-((2-(2-Ethoxyphenoxy)Ethyl)Amino)Propyl)-2-Methoxybenzenesulfonamide Hydrochloride
中文名称盐酸坦索罗辛
IUPAC名称5-(2-((2-(2-ethoxyphenoxy)ethyl)amino)propyl)-2-methoxybenzenesulfonamide hydrochloride
其它别名Tamsulosinehydrochloride; Benzenesulfonamide, 5-[2-[[2-(2-Ethoxyphenoxy)Ethyl]Amino]Propyl]-2-Methoxy-, Monohydrochloride (9Ci); Dl-Tamsulosin Hydrochloride; (-)-(R)-5-[2-[2-(2-Ethoxyphenoxy)Ethylamino]Propyl]-2-Methoxybenzenesulfonamide Hydrochloride; Tamsulosin Hydrochloride; Tamuzosin Hydrochloride; Racemic Tamsulosin Hydrochloride (50 Mg)
CAS编号80223-99-0
MFCD编号:MFCD09954593
EINECS号:617-011-7
分子式:C20H29ClN2O5S
分子量:444.98
产品CID: 1796742
产品分类原料药 → 泌尿系统用药 → 其它泌尿系统用药

相似结构搜索
InChIKey: ZZIZZTHXZRDOFM-UHFFFAOYNA-N
InChI=1S/C20H28N2O5S.ClH/c1-4-26-17-7-5-6-8-18(17)27-12-11-22-15(2)13-16-9-10-19(25-3)20(14-16)28(21,23)24;/h5-10,14-15,22H,4,11-13H2,1-3H3,…
计算化学: 氢键受体数7.0氢键供体数3.0可旋转键数11.0

物理性质

熔点230.6 °C (文献)
沸点595.5 °C at 760 mmHg
闪点313.9 °C
PSA:108.26
LogP:5.3149
蒸汽压3.79E-14 mmHg at 25 °C
溶解性DMSO (Slightly), Methanol (Slightly), Water (Slightly)
外观形态白色结晶
储存条件2-8°C
产品应用该化合物用于治疗良性先天肥大.

MSDS等安全信息

警示词Warning
危险描述H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]
防范说明P264, P270, P301+P317, P330, and P501
UN编号NONH for all modes of transport

上下游产品

(+/-)-Tamsulosin hydr°Chloride (+)-Tamsulosin 2-(2-ethoxyphenoxy)ethanol 2-(2-ethyloxyphenoxy)ethyl methanesulfonate

合成工艺路线路线简述

2-(2-乙氧基苯氧基)乙基胺,5-丙酮基-2-甲氧基苯磺酰胺置于raney Nickel 氢气,盐酸体系中,用甲醇作为反应溶剂,50.0 °C,275.8 Kpa 条件下,反应 30.0H,反应生成盐酸坦索罗辛
参考文献:Process For The Resolution Of Racemic (R,S)-5-(2-(2-(2-Ethoxyphenoxy) Ethylamino)Propyl)-2-Methoxybenzene Sulfonamide (Tamsulosin),Its Novel R And S Isomers And Their Salts And Processes For Their Preparation
标题:Process For The Resolution Of Racemic (R,S)-5-(2-(2-(2-Ethoxyphenoxy) Ethylamino)Propyl)-2-Methoxybenzene Sulfonamide (Tamsulosin),Its Novel R And S Isomers And Their Salts And Processes For Their Preparation
摘要:描述了一种改进的过程,用于在5-(2-(2-(2-乙氧基苯氧基)乙基氨基)丙基)-2-甲氧基苯磺胺作为自由基或其某些盐的任意比例的混合物中,与bpa的s或r形式进行分离,以获得对映异构体高度纯净的r和s异构体,作为标题化合物的明确的自由基或盐.还描述了5-(2-(2-(2-乙氧基苯氧基)乙基氨基)丙基)-2-甲氧基苯磺胺及其盐的新型r和s异构体,以及它们的制备过程.

海关参考信息

2902600000-乙苯
2907210001-间苯二酚
2922110001-单乙醇胺
2908199090-其他酚的卤化衍生物
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详情请参考：📖 海关编码查询和海关进出口税则

专利信息

专利号:US-7619116-B2
优先权日:2003-12-17
标题:Intermediates for the synthesis of (R)-tamsulosin and of its pharmaceutically acceptable salts and process for their preparation
发明人：DAMBRIN VALERY; LENOIR JEAN-YVES; SCHNEIDER JEAN-MARIE; GUILLAMOT GERARD; FOLLET MICHEL; BECKER ABRAM
权利人:PRODUCTS CHIMIQUES AUXILIAIRES
摘要:A subject matter of the present invention is novel intermediates for the synthesis of (R)-tamsulosin and of its pharmaceutically acceptable salts, and also the associated preparation process.

专利号:US-7538246-B2
优先权日:2003-12-29
标题:Synthesis of optically pure(r)-5-(2-amynopropyl)-2-methoxybenzenesulphonamide
发明人：MOHAR BARBARA
权利人:LEK PHARMACEUTICALS
摘要:The present invention relates to a new process for the preparation of optically pure(R)-5-(2-aminopropyl)-2-methoxybenzenesulphonamide, which is an intermediate in the synthesis of tamsulosin.

专利号:US-2006148046-A1
优先权日:2004-12-31
标题 :Enzymatic process for the preparation of an intermediate compound and use thereof for the synthesis of tamsulosin hydrochloride

专利号:WO-2011011384-A9
优先权日:2009-07-20
标题 :Synthesis of dendrimer conjugates

专利号:US-2007106079-A1
优先权日:2003-12-17
标题:Novel intermediates for the synthesis of (r)-tamsulosin and of its pharmaceutically acceptable salts and process for their preparation

专利号:US-2007155989-A1
优先权日:2003-12-29
标题 :Synthesis of optically pure(r)-5-(2-amynopropyl)-2-methoxybenzenesulphonamide