CAS: 827-99-6; 3-(Trifluoromethoxy)Phenol

上下游产品

CAS号263266-23-5 3-(3-三氟甲基苯氧基)-苯胺 | CAS号205371-26-2 2-溴-5-(三氟甲氧基)苯酚 | CAS号886499-93-0 4-溴-3-三氟甲氧基苯酚 | CAS号142738-94-1 3-(三氟甲氧基)苯甲醚 | CAS号653578-81-5 2-chloro-3-(tri...

Bromo-[3-(Trifluoromethoxy)Phenyl]-Magnesium置于air体系中,用 四氢呋喃 作为反应溶剂,-10.0 °C,1.72 Mpa 条件下,反应 0.06H,以81%的收率获得产物3-三氟甲氧基苯酚
参考文献:格氏试剂的需氧氧化连续流式合成功能化苯酚
标题:格氏试剂的需氧氧化连续流式合成功能化苯酚
摘要:苯酚是化学工业中的重要化合物.描述了在连续的气液分段流系统中使用压缩空气通过直接氧化芳基格氏试剂来制备苯酚的一种经济,绿色的方法.该工艺可耐受各种官能团,包括对氧化敏感的官能团,例如烯烃,胺和硫醚.通过将苯并炔介导的芳基镁中间体的在线反应生成与好氧氧化相集成,建立了一种能够以模块化方式制备2-官能化苯酚的简便的三步单流方法.
DOI:10.1002/anie.201310572

专利信息

专利号:US-10040752-B2
优先权日:2015-08-24
标 题 :Synthesis of levomethadone hydrochloride or dextromethadone hydrochloride and methods for use thereof
发明人：MKRTCHYAN GNEL; YAO QINGWEI
权利人:CODY LABORATORIES INC
摘要:Highly efficient methods for synthesis of levomethadone hydrochloride or dextromethadone hydrochloride are provided starting from D-alanine, or L-alanine, respectively, with retention of configuration. Methods for treating a subject are provided comprising administering a composition comprising an effective amount of levomethadone hydrochloride having not more than 10 ppm dextromethadone.

专利号:US-2004110228-A1
优先权日:2002-04-01
标 题:Combinatorial organic synthesis of unique biologically active compounds
发明人：MCALPINE SHELLI R; TAYLOR RACHEL E; BOLLA MEGAN L; SEGALL ANCA M
摘要:The invention provides a method for making a combinatorial library of cyclic compounds, such as Holliday junction-trapping compounds, comprising the steps of (a) obtaining a plurality of trimers according to the generic structure X 1- X 2- X 3 , wherein X 1 , X 2 and X 3 can be independently any naturally or nonnaturally occurring amino acids or peptidomimetics thereof; (b) optionally coupling a spacer S to the trimer at either end; (c) cyclizing two trimers or trimer-spacer conjugates in a head-to-tail orientation; thereby obtaining a combinatorial library of compounds, wherein the library does not include an unmodifed or naturally occurring Holliday Junction-trapping compounds. The invention additionally provides methods macrocyclic compounds that are synergimycin derivatives.

专利号:US-2019002394-A1
优先权日:2015-08-24
标 题 :Synthesis of levomethadone hydrochloride or dextromethadone hydrochloride and methods for use thereof

专利号:CN-1359890-A
优先权日:2001-12-11
标题 :Synthesis of 3,5-Ditrifluoromethylphenyl-hydroquinone

专利号:US-2017057909-A1
优先权日:2015-08-24
标 题 :Synthesis of levomethadone hydrochloride or dextromethadone hydrochloride and methods for use thereof

专利号:EP-3341354-A1
优先权日:2015-08-24
标 题 :Synthesis of levomethadone hydrochloride or dextromethadone hydrochloride and methods for use thereof