CAS: 1350514-68-9; (33R,35S,91R,92R,5S)-5-(Tert-Butyl)-N-((1R,2S)-1-((Cyclopropylsulfonyl)Carbamoyl)-2-Vinylcyclopropyl)-17-Methoxy-4,7-Dioxo-2,8-Dioxa-6-Aza-1(2,3)-Quinoxalina-3(3,1)-Pyrrolidina-9(1,2)-Cyclopropanacyclotetradecaphane-35-Carboxamide

上下游产品

(1Ar,5S,8S,10R,22Ar)-5-(1,1-二甲基乙基)-1,1A,3,4,5,6,9,10,18,19,20,21,22,22A-十四氢-14-甲氧基-3,6-二氧代-8H-7,10-亚甲基环丙烷并[18,19][1,10,3,6]二氧杂二环草壬基十八碳-7-烯[11,12-B]喹喔啉-8-羧酸 (1Ar,5S,8S,10R,22Ar)-5-Tert-Butyl-14-Methoxy-3,6-Dioxo-1,1A,3,4,5,6,9,10,18,19,20,21,22,22A-Tetradeca-Hydro-8H-7,10-Methanocyclopropa[18,19][1,10,3,6]Dioxadiazacyclononadecino[11,12-B]Quinoxaline-8-Carboxylic Acid Hydrate 1206524-85-7
(1R,18R,20R,27S)-24-Tert-Butyl-7-Methoxy-22,25-Dioxo-2,21-Dioxa-4,11,23,26-Tetrazapentacyclo[24.2.1.03,12.05,10.018,20]Nonacosa-3,5(10),6,8,11-Pentaene-27-Carboxylic Acid
Mk-5172中间体 Methyl (1Ar,5S,8S,10R,22Ar)-5-Tert-Butyl-14-Methoxy-3,6-Dioxo-1,1A,3,4,5,6,9,10,18,19,20,21,22,22A-Tetradecahydro-8H-7,10-Methanocyclopropa[18,19][1,10,3,6]Dioxa-Diazacyclononadecino[11,12-B]Quinoxaline-8-Carboxylate 1206524-84-6
Methyl 3-Methyl-N-({[(1R,2R)-2-Pent-4-En-1-Ylcyclopropyl]Oxy}Carbonyl)-L-Valyl-(4R)-4-[(7-Methoxy-3-Vinylquinoxalin-2-yl)Oxy]-L-Prolinate 1206524-82-4
(33R,35S,91R,92R,5S,E)-5-(叔丁基)-17-甲氧基-4,7-二氧代-2,8-二氧杂-6-氮杂-1(2,3)- 喹喔啉-3(3,1)- 吡咯烷-9(1,2)- 环丙烷环十四烷-13-烯-35-甲酸酯 Methyl (1Ar,5S,8S,10R,18E,22Ar)-5-Tert-Butyl-14-Methoxy-3,6-Dioxo-1,1A,3,4,5,6,9,10,20,21,22,22A-Dodecahydro-8H-7,10-Methanocyclopropa[18,19][1,10,3,6]Dioxadiazacyclononadecino[11,12-B]Quinoxaline-8-Carboxylate 1206524-83-5
(1Ar,5S,8S,10R,22Ar)-18,19-二去氢-5-(叔丁基)-1,1A,3,4,5,6,9,10,20,21,22,22A-十二氢-14-甲氧基-3,6-二氧代-8H-7,10-甲桥环丙烯并[18,19][1,10,3,6]二氧杂二氮杂环十九碳九烯并[11,12-B]喹喔啉-8-羧酸甲酯 Methyl (1Ar,5S,8S,10R,22Ar)-5-Tert-Butyl-14-Methoxy-3,6-Dioxo-18,19-Didehydro-1,1A,3,4,5,6,9,10,20,21,22,22A-Dodecahydro-8H-7,10-Methanocyclopropa[18,19][1,10,3, 6]Dioxadiazacyclononadecino[11,12-B]Quinoxaline-8-Carboxylate 1425038-23-8
(2S,4R)-4-((3-氯-7-甲氧基喹喔啉-2-基)氧基)-1-((S)-3,3-二甲基-2-(((1R,2R)-2-(戊-4-烯-1-基)环丙氧基)羰基)氨基)丁酰基)吡咯烷-2-羧酸甲酯 (2S,4R)-Methyl 4-((3-Chloro-7-Methoxyquinoxalin-2-yl)Oxy)-1-((S)-3,3-Dimethyl-2-((((1R,2R)-2-(Pent-4-En-1-yl)Cyclopropoxy)Carbonyl)Amino)Butanoyl)Pyrrolidine-2-Carboxylate 1206524-81-3
(2S)-2-[[(1R,2R)-2-[5-[6-Methoxy-3-[(3R,5S)-5-Methoxycarbonylpyrrolidin-3-Yl]Oxyquinoxalin-2-Yl]Pentyl]Cyclopropyl]Oxycarbonylamino]-3,3-Dimethylbutanoic Acid 1425038-26-1 (S)-2-(((1R,2R)-2-(5-(6-Methoxy-3-((3R,5S)-5-(Methoxycarbonyl)Pyrrolidin-3-Yloxy)Quinoxalin-2-yl)Pent-4-Ynyl)Cyclopropoxy)Carbonylamino)-3,3-Dimethylbutanoic Acid 1425038-22-7 1-(Tert-Butyl) 2-Methyl (2S,4R)-4-((3-Chloro-7-Methoxyquinoxalin-2-yl)Oxy)Pyrrolidine-1,2-Dicarboxylate 1206524-79-9

(1Ar,5S,8S,10R,22Ar)-18,19-二去氢-5-(叔丁基)-1,1A,3,4,5,6,9,10,20,21,22,22A-十二氢-14-甲氧基-3,6-二氧代-8H-7,10-甲桥环丙烯并[18,19][1,10,3,6]二氧杂二氮杂环十九碳九烯并[11,12-B]喹喔啉-8-羧酸甲酯置于吡啶,甲醇,氢气,盐酸-N-乙基-N'-(3-二甲氨基丙基)碳二亚胺体系中,用 四氢呋喃 用作溶剂,-5.0~45.0 °C,344.75 Kpa 条件下,反应 16.0H,反应生成格佐匹韦
参考文献:用于治疗丙型肝炎病毒的强效ns3 / 4A蛋白酶抑制剂grazoprevir的合成
标题:用于治疗丙型肝炎病毒的强效ns3 / 4A蛋白酶抑制剂grazoprevir的合成
摘要:据报道,Grazoprevir的有效合成.从四个容易获得的结构单元开始,制备格拉佐泼韦的总收率为51%,纯度大于99.9%,可用于制药用途.
Doi:10.1021/acs.Orglett.8B03173