CAS: 17388-39-5; (4Ar,5R,6S)-4A-Hydroxy-6-(((2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(Hydroxymethyl)Tetrahydro-2H-Pyran-2-yl)Oxy)-5-Vinyl-4,4A,5,6-Tetrahydropyrano[3,4-C]Pyran-1(3H)-One
该化合物是自然形成的,具有显著抗氧化特性的甘蓝表面类,有助于其在皮肤护理和化妆品配方中的潜在应用. 其蒸发自由基和稳定细胞膜的能力可以帮助保护皮肤免受氧化性压力,促进更具复原力和年轻化的外观.
- 英文名称(4Ar,5R,6S)-4A-Hydroxy-6-(((2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(Hydroxymethyl)Tetrahydro-2H-Pyran-2-yl)Oxy)-5-Vinyl-4,4A,5,6-Tetrahydropyrano[3,4-C]Pyran-1(3H)-One
- 中文名称獐牙菜苦甙
- IUPAC名称(4aR,5R,6S)-4a-hydroxy-6-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)-5-vinyl-4,4a,5,6-tetrahydro-1H,3H-pyrano[3,4-c]pyran-1-one
- 其它别名Swertiamaroside; (5R,6S)-5-Ethenyl-4a-hydroxy-6-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-3,4,5,6-tetrahydropyrano[5,4-c]pyran-1-one
- CAS编号17388-39-5
- MFCD编号:MFCD07783984
- FDA UNII编号:4038595T7Y
- 分子式:C16H22O10
- 分子量:374.34
- 产品CID: 888394
- 产品分类原料药 → 消化系统用药 → 胃肠解痉药
- 相似结构搜索
- 产品信息参考
; - InChIKey: HEYZWPRKKUGDCR-QBXMEVCASA-N
- HEYZWPRKKUGDCR-QBXMEVCASA-N…
- 计算化学: 氢键受体数10.0氢键供体数5.0可旋转键数4.0
物理性质
MSDS等安全信息
合成工艺路线路线简述
2'-(2'',3''-Dihydroxybenzoyl)Swertiamarin置于sodium Methylate体系中,用 甲醇 用作溶剂,化学反应 3.0H,以0.4 Mg的收率获得2,3-二羟基苯甲酸甲酯
参考文献:Rigenolide A,一种新的具有环丁烷骨架的类secidridoid糖苷,和三个来自gentiana Rigescens Franch的新的酰化类secidridoid糖苷.
标题:Rigenolide A,一种新的具有环丁烷骨架的类secidridoid糖苷,和三个来自gentiana Rigescens Franch的新的酰化类secidridoid糖苷.
摘要:Rigenolide A(1),一种具有环丁烷骨架的新的类仲油苷和三个新的酰化的类总糖苷,2'-(2,3-二羟基苯甲酰基)-龙胆苦苷(2),2'-((2,3-二羟基苯甲酰基)-Swertiamarin( 3)从龙胆龙胆中分离出3'-(2,3-二羟基苯甲酰基)-苦味子苷(4)以及两个norididoids(7和8)和两个已知的secoiridoid苷(5和6).广泛的光谱分析阐明了新化合物的结构.评估分离的化合物的dpph自由基清除活性.
Doi:10.1016/j.Fitote.2013.08.006
海关参考信息
- 2901210000-乙烯
2901220000-丙烯
2905122000-异丙醇
2905143000-叔丁醇 - 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
- 详情请参考：📖 海关编码查询和海关进出口税则
专利信息
专利号:CN-113081878-A
优先权日:2021-04-30
标题:A combination and application of synergistically promoting hyaluronic acid synthesis in skin
专利号:CN-113081878-B
优先权日:2021-04-30
标题 :A combination and application of synergistically promoting hyaluronic acid synthesis in skin
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📌 第三方产品分析报告
主要参考文献
1: Wang W, Tan Y, Mao J, Xiong W. Swertiamarin and sweroside are potential inhibitors of COVID-19 based on the silico analysis. Medicine (Baltimore). 2024 Nov 8;103(45):e40425. doi: 10.1097/MD.0000000000040425.
2: Chen H, Liu P, Yu R, Mohammadtursun N, Aikemu A, Yang X. Swertiamarin ameliorates type 2 diabetes by activating ADRB3/UCP1 thermogenic signals in adipose tissue. Phytomedicine. 2024 Oct 30;135:156190. doi: 10.1016/j.phymed.2024.156190. Epub ahead of print. 15(10):1255. doi: 10.3390/genes15101255.
4: Cao C, Hu B, Wang J, Li W, Guo L, Sheng J, Zhang C. Swertianin Promotes Anti- Tumor activity by facilitating Macrophage M1 polarization via STING signaling. Int Immunopharmacol. 2024 Dec 5;142(Pt B):113182. doi: 10.1016/j.intimp.2024.113182. Epub 2024 Sep 18. 44(8):1545-1552. Chinese. doi: 10.12122/j.issn.1673-4254.2024.08.13.
合成参考文献
参考文献:10.1248/cpb.56.485
摘要:Wang Z, Ma C, Tang S, Xiao H, Kakiuchi N, Kida H, Hattori M. Qualitative and quantitative analysis of Swertia herbs by high performance liquid chromatography-diode array detector-mass spectrometry (HPLC-DAD-MS). Chem Pharm Bull (Tokyo). 2008 Apr;56(4):485–90. doi: 10.1248/cpb.56.485.
参考文献:10.1002/ptr.3496
摘要:Wei S, Chen G, He W, Chi H, Abe H, Yamashita K, Yokoyama M, Kodama H. Inhibitory Effects of Secoiridoids from the Roots of Gentiana straminea on Stimulus‐induced Superoxide Generation, Phosphorylation and Translocation of Cytosolic Compounds to Plasma Membrane in Human Neutrophils. Phytotherapy Research. 2011 May 17;26(2):168–73. doi: 10.1002/ptr.3496.
参考文献:10.1016/j.biopha.2020.110561
摘要:Jaishree V, Narsimha S. Swertiamarin and quercetin combination ameliorates hyperglycemia, hyperlipidemia and oxidative stress in streptozotocin-induced type 2 diabetes mellitus in wistar rats. Biomed Pharmacother. 2020 Oct;130():110561. doi: 10.1016/j.biopha.2020.110561.
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