CAS: 2150-44-9; Methyl 3,5-Dihydroxybenzoate

上下游产品

CAS号67-56-1 甲醇 | CAS号99-10-5 3,5-二羟基苯甲酸 | CAS号2150-36-9 5-(甲氧基羰基)-1,3-亚... | CAS号74-88-4 碘甲烷 | CAS号186581-53-3 重氮甲烷 | CAS号77-78-1 硫酸二甲酯 | CAS号74-89-5 氨基甲烷 | CAS号75-04-7 乙胺 | CAS号7647-01-0 盐酸 | CAS号106325-78-4 5-[(Z)-2-phenyl... | CAS号111682-05-4 methyl 3,5-bis(... | CAS号110361-76-7 methyl 2,3,5-tr... | CAS号501-36-0 白藜芦醇 | CAS号94169-62-7 3,5-二异丙氧基苯甲酸甲酯 | CAS号182250-68-6 3,5-双(二苯叔丁硅氧基)苯甲酸甲酯 | CAS号199277-76-4 1-(bromomethyl)... | CAS号2150-36-9 5-(甲氧基羰基)-1,3-亚... | CAS号198623-57-3 Benzeneacetonit... | CAS号199192-20-6 (3,5-didodecoxy...

3,5-二羟基苯甲酸置于草酰氯,N,N-二甲基甲酰胺体系中,用 二氯甲烷 用作溶剂,化学反应生成3,5-二羟基苯甲酸甲酯
参考文献:小分子文库官能用半胱氨酸反应性部分的使用筛选共价抑制剂dna显示†往最‡
标题:小分子文库官能用半胱氨酸反应性部分的使用筛选共价抑制剂dna显示†往最‡
摘要:Dna编码的化学文库越来越多地用于鉴定药物发现或化学生物学的线索.尽管对共价抑制剂的兴趣重新兴起,但通常设计的文库中已过滤出合成素,以实现可通过共价相互作用与靶标结合的反应性功能.在本文中,我们报告了两个包含迈克尔受体以鉴定半胱氨酸反应性配体的文库的合成.我们开发了一种简单的程序,可使用微阵列格式的文库的dna显示来区分共价和高亲和力非共价抑制剂.该方法已用已知的共价和高亲和力非共价激酶抑制剂进行了验证.文库的筛选显示了mek2和erbb2的新型共价抑制剂.
Doi:10.1039/c6Md00242K

专利信息

专利号:US-10730904-B2
优先权日:2012-11-14
标 题:Method for liquid-phase synthesis of nucleic acid
发明人：NONOGAWA MITSURU; NAGATA TOSHIAKI; SAITO HIDEKI; YASUMA TSUNEO
权利人:TAKEDA PHARMACEUTICALS CO
摘要:In this method, an oligonucleotide represented by formula (II) [wherein Y 1 , Q, Base, r and r′ are each as defined in claim 1 ] is prepared by using, as a synthesis unit, a novel nucleoside monomer compound represented by formula (I) [wherein X, R 1 , Y, Base, Z, Ar, R 2 , R 3 and n are each as defined in claim 1 ]. The novel nucleoside monomer compound is a nucleoside, the base moiety of which is substituted with an aromatic-hydrocarbon-ring-carbonyl or -thiocarbonyl group having at least one hydrophobic group. The method can dispense with column-chromatographic purification in every reaction, and enables base elongation not only in the 3′-direction but also in the 5′-direction, thus attaining efficient liquid-phase mass synthesis of an oligonucleotide.

专利号:US-9777034-B2
优先权日:2013-05-21
标题 :Modular synthesis of amphiphilic Janus glycodendrimers and their self-assembly into glycodendrimersomes
发明人：PERCEC VIRGIL
权利人:UNIV PENNSYLVANIA
摘要:The invention concerns compounds of the formula (I) wherein: Y 1 and Y 2 are independently a monosaccharide or disaccharide; X 1 and X 2 are independently —(R 9 —O) m —, —(R 10 ) p —, —O—(R 11 —O) q —, —R 16 —O—R 17 —O— or a covalent bond; Q 1 and Q 2 are independently a nitrogen-containing heterocycle moiety; Z 1 and Z 2 are independently —(O—R 7 )—, —(O—C(â•?O)—R 8 )a-, —O—C(â•?O)—R 12 —C(=0)-R 13 —, —O—C(â•?O)—R 14 —C(â•?O)—R 15 or a covalent bond; R 7 -R 17 are each independently C 1 -C 6 alkyl; R 1 -R 6 are each independently a linear or branched alkyl group; b, c, d, e, f, and g are 0 or 1, provided b+c+d equals at least 2 and e+f+g equals at least 2; and a, m, p, and q are each an integer from 1-6.

专利号:US-10508092-B2
优先权日:2016-09-02
标题 :Synthesis of novel analogs of diptoindonesin G, compounds formed thereby, and pharmaceutical compositions containing them
发明人：XU WEI; TANG WEIPING; LIU JITIAN; KOLESAR JILL
权利人:WISCONSIN ALUMNI RES FOUND
摘要:Disclosed are unnatural analogs of Diptoindonesin G, methods to make the analogs, pharmaceutical compositions containing the analogs, and methods of using the analogs to inhibit neoplastic cell growth.

专利号:US-12037641-B2
优先权日:2015-11-20
标题:Modified nucleotide reagents
发明人：SHEN GENE; YUE STEPHEN; SEBO LUBOMIR; BROGLEY LOUIS
权利人:PACIFIC BIOSCIENCES CALIFORNIA INC
摘要:Labeled nucleotide analogs comprising at least one avidin protein, at least one dye-labeled compound, and at least one nucleotide compound are provided. The analogs are useful in various fluorescence-based analytical methods, including the analysis of highly multiplexed optical reactions in large numbers at high densities, such as single molecule real time nucleic acid sequencing reactions. The analogs are detectable with high sensitivity at desirable wavelengths. They contain structural components that modulate the interactions of the analogs with DNA polymerase, thus decreasing photodamage and improving the kinetic and other properties of the analogs in sequencing reactions. Also provided are nucleotide and dye-labeled compounds of the subject analogs, as well as intermediates useful in the preparation of the compounds and analogs. Compositions comprising the compounds, methods of synthesis of the intermediates, compounds, and analogs, and mutant DNA polymerases are also provided.

专利号:US-2018065945-A1
优先权日:2016-09-02
标 题 :Synthesis of novel analogs of diptoindonesin g, compounds formed thereby, and pharmaceutical compositions containing them

专利号:US-5302729-A
优先权日:1989-10-06
标 题:Dibenzo crown monomers and polymers formed therefrom
发明人：GIBSON HARRY W; DELAVIZ YADOLLAH
权利人:VIRGINIA TECH INTELL PROP
摘要:Novel bis(extraannular functionally-substituted phenylene) crown compounds, useful as chelating agents or in the synthesis of condensation polymers containing large semi-rigid macrocycles in the polymer backbone, are described. A broad range of functional groups (preferably in the 5-position) can be used in the 1,3-phenylene varieties. Carboxy functional groups are used in certain novel 1,2-phenylene crowns.