CAS: 2766-43-0; Boc-Ser-Ome

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叔-丁基氯甲酸酯置于potassium Carbonate,Sodium Hydroxide体系中,用 1,4-二氧六环,水,N,N-二甲基甲酰胺 用作溶剂,化学反应 28.5H,反应生成Boc-L-丝氨酸甲酯
参考文献:三氟甲基硒代氨基酸衍生物及其制备方法
标题:三氟甲基硒代氨基酸衍生物及其制备方法
摘要:本发明公开一种三氟甲基硒代氨基酸衍生物及其制备方法,该制备方法包括以下步骤:以氨基酸为起始原料与n‑boc保护试剂进行n‑boc保护反应,得到氨基n‑boc保护的氨基酸;将氨基n‑boc保护的氨基酸与酯化试剂进行酯化反应,得到酯化产物;将酯化产物与磺酰化试剂进行磺酰化反应,得到磺酰化产物;将磺酰化产物与三氟甲硒基盐进行三氟甲硒基化反应,得到氨基n‑boc保护的三氟甲基硒代氨基酸衍生物.该反应不仅操作简便,条件温和,产率较高,官能团耐受性很好,而且原料廉价易得,为合成三氟甲基硒代氨基酸衍生物提供了一种非常实用的方法.

专利信息

专利号:US-9643915-B2
优先权日:2013-03-15
标题:Methods for the synthesis of sphingomyelins and dihydrosphingomyelins
发明人：ONICIU DANIELA CARMEN; HECKHOFF STEFAN; OSWALD BENOIT; REBMANN PETER; PEER ANDREAS; GONZALEZ MIGUEL; SAUTER PATRIK
权利人:CERENIS THERAPEUTICS HOLDING SA
摘要:The present invention includes methods for the synthesis of sphingomyelins and dihydrosphingomyelins. The present invention also includes methods for the synthesis of sphingosines and dihydrosphingosines. The present invention further includes methods for the synthesis of ceramides and dihydroceramides.

专利号:US-9708354-B2
优先权日:2013-03-15
标 题:Methods for the synthesis of sphingomyelins and dihydrosphingomyelins
发明人：ONICIU DANIELA CARMEN; HECKHOFF STEFAN; OSWALD BENOIT; REBMANN PETER; PEER ANDREAS; GONZALEZ MIGUEL; SAUTER PATRIK
权利人:CERENIS THERAPEUTICS HOLDING SA
摘要:The present invention includes methods for the synthesis of sphingomyelins and dihydrosphingomyelins. The present invention also includes methods for the synthesis of sphingosines and dihydrosphingosines. The present invention further includes methods for the synthesis of ceramides and dihydroceramides.

专利号:US-11427530-B2
优先权日:2018-02-09
标 题 :Synthesis of 4-chlorokynurenines and intermediates
发明人：LEVIN DANIEL; LEEMING PETER; EISENREICH EMERICH; LIU XUEJUN KARL
权利人:VISTAGEN THERAPEUTICS INC
摘要:The invention relates to an overall enantio-specific synthesis of 4-chlorokynurenine compounds, in particular L-4-chlorokynurenine, with improved yields. Large-scale syntheses are disclosed. The invention also relates to novel intermediates in the synthesis of L-4-chlorokynurenine.

专利号:US-2018265547-A1
优先权日:2014-07-18
标 题 :Z-selective olefin metathesis of peptides
发明人：MANGOLD SHANE L; GRUBBS ROBERT H
权利人:CALIFORNIA INST OF TECHN
摘要:The invention relates generally to the synthesis of modified amino acids and modified peptides in the presence of cyclometalated catalysts. The invention has utility in the fields of catalysis, organic synthesis, polymer chemistry, and industrial and fine chemicals chemistry.

专利号:WO-9726002-A1
优先权日:1996-01-17
标 题:Synthesis of conformationally restricted amino acids, peptides and peptidomimetics by catalytic ring closing metathesis
发明人：GRUBBS ROBERT H; MILLER J SCOTT; BLACKWELL HELEN E
权利人:CALIFORNIA INST OF TECHN
摘要:A method for synthesizing conformationally restricted amino acids, peptides, and peptidomimetics by ring closing metathesis. The method includes the steps of synthesizing a peptide precursor containing first and second unsaturated C-C bonds and contacting the peptide precursor with an RCM catalyst to yield a conformationally restricted peptide. Suitable peptide precursors may contain two or more unsaturated C-C bonds. These bonds may be olefinic bonds and may be contained in first and second alkenyl groups which may be allyl groups. The RCM catalyst may be a Ruthenium or Osmium carbene complex catalyst and more specifically, a Ruthenium or Osmium carbene complex catalyst that includes a Ruthenium or Osmium metal center that is in a +2 oxidation state, has an electron count of 16, and is pentacoordinated. The method may be carried out using solid-phase-peptide-synthesis techniques. In this embodiment, the precursor, which is anchored to a solid support, is contacted with an RCM catalyst and the product is then cleaved from the solid support to yield a conformationally restricted peptide.

专利号:US-5451691-A
优先权日:1992-05-07
标题 :Synthesis of cosmetic ingredients
发明人：CRAWFORD DUNCAN J; RAWLINGS ANTHONY V; SCOTT IAN R
权利人:ARDEN ELIZABETH CO
摘要:A method of synthesis of ω-hydroxy fatty acid containing ceramides having the general structure (1). ##STR1## where A represents CH 2 or --CHâ•?CH--Y represents a residue of a C 14 to C 22 fatty acid having the structure (2) ##STR2## where Z is --OH or an epoxy oxygen n x is an integer of from 12 to 20 n y is an integer of from 20 to 40 n z is 0 or an integer of from 1 to 4 n a is an integer of from 8 to 50 n b is an integer of from 10 to 100 n and n is an integer of from 7 to 27.