CAS: 321-23-3; 4-Bromo-2-Fluoronitrobenzene

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CAS号367-24-8 4-溴-2-氟苯胺 | CAS号1073-06-9 间溴氟苯 | CAS号610-38-8 1-溴-3,4-二硝基苯 | CAS号348-54-9 邻氟苯胺 | CAS号586-78-7 对溴硝基苯 | CAS号1089280-53-4 tert-butyl 4-(4... | CAS号367-24-8 4-溴-2-氟苯胺 | CAS号337915-79-4 4-溴-2-甲基氨基苯胺 | CAS号302800-13-1 5-溴-N-甲基-2-硝基苯胺 | CAS号883500-73-0 5-溴-7-氟-1H-吲哚 | CAS号5228-61-5 5-溴-2-硝基苯胺 | CAS号1038408-35-3 5-溴-N1-异丙基苯-1,2-二胺 | CAS号103966-66-1 2-硝基-5-溴苯甲醚 | CAS号256935-99-6 7-fluoro-1H-ind... | CAS号1233145-65-7 tert-butyl 4-(3...

1,2-二硝基-4-溴化苯置于potassium Fluoride,N,N-二甲基甲酰胺体系中,化学反应生成2-氟-4-溴硝基苯
参考文献:Aromatic Fluorine Compounds. Vii. Replacement Of Aromatic-Cl And-No2 Groups By-F1,2
标题:Aromatic Fluorine Compounds. Vii. Replacement Of Aromatic-Cl And-No2 Groups By-F1,2
摘要:
Doi:10.1021/ja01604A022

专利信息

专利号:US-9573939-B2
优先权日:2011-09-08
标题:Substituted benzofuran compounds and methods of use thereof for the treatment of viral diseases
发明人：MCCOMAS CASEY C; LIVERTON NIGEL J; HABERMANN JOERG; KOCH UWE; NARJES FRANK; LI PENG; PENG XUANJIA; SOLL RICHARD; WU HAO; PALANI ANANDAN; DAI XING; LIU HONG; HE SHUWEN; DANG QUN
权利人:MCCOMAS CASEY C; LIVERTON NIGEL J; HABERMANN JOERG; KOCH UWE; NARJES FRANK; LI PENG; PENG XUANJIA; SOLL RICHARD; WU HAO; PALANI ANANDAN; DAI XING; LIU HONG; HE SHUWEN; DANG QUN; MERCK SHARP & DOHME; MSD ITALIA SRL
摘要:The present invention relates to compounds of formula (I) that are useful as hepatitis C virus (HCV) NS5B polymerase inhibitors, the synthesis of such compounds, and the use of such compounds for inhibiting HCV NS5B polymerase activity, for treating or preventing HCV infections and for inhibiting HCV viral replication and/or viral production in a cell-based system.

专利号:US-9790207-B2
优先权日:2015-09-04
标题 :Pan-genomic inhibitors of NS5A protein encoded by HCV, pharmaceutical compositions, intermediates for inhibitor synthesis, and their synthesis and application methods
发明人：IVACHTCHENKO ALEXANDRE VASILIEVICH; MITKIN OLEG DMITRIEVICH
权利人:IVACHTCHENKO ALEXANDRE VASILIEVICH; IVASHCHENKO ANDREY ALEXANDROVICH; SAVCHUK NIKOLAY FILIPPOVICH; ALLA CHEM LLC
摘要:Compound represented by formula 1: n nor a pharmaceutically acceptable salt, a hydrate, a crystalline form, or a stereoisomer thereof, wherein:n nR1 is hydrogen, tert-butoxycarbonyl,n n nwhere R11 is an optionally substituted C 1 -C 6 alkyl, an optionally substituted C 3 -C 6 cycloalkyl, or an optionally substituted C 1 -C 6 alkyloxy, and arrows (â†?) indicate the position of substituents attachment;n nR2 is hydrogen, halogen, or C 1 -C 4 alkyl;n nR3 is an optionally substituted aryl, an optionally substituted aryloxy, an optionally substituted arylsulfanyl, an optionally substituted arylamino, or an optionally substituted nitrogen hetaryl;n n n n n n n n n n n n n where R41 is an optionally substituted C 1 -C 6 alkyl, an optionally substituted C 3 -C 6 cycloalkyl, or an optionally substituted C 1 -C 6 alkyloxy; X is buta-1,3-diynylene or 1,4-phenylene; arrows (â†?) indicate the position of substituents attacment.

专利号:WO-2023072966-A1
优先权日:2021-10-26
标题:Imidazolone derivatives as inhibitors of protein kinases in particular dyrk1a, clk1 and/or clk4
发明人：DEAU EMMANUEL; GEORGE PASCAL; MEIJER LAURENT; MIEGE FRÉDÉRIC
权利人:PERHA PHARMACEUTICALS
摘要:The present invention relates to a compound of formula (I) wherein R 1 represents a (C 4 -C 6) alkyl group, a (C 3 -C 8) cycloalkyl group, a bridged (C 6 -C 10 )cycloalkyl group, a fused phenyl group, a substituted phenyl group, a R'-L- group, wherein L is either a single bond or a (C 1 -C 3 )alkanediyl group, and R' represents, a (C 3 -C 8 )heterocycloalkyl group, or a (C 3 -C 8 )heteroaryl group, or a R''-L- group wherein L is a (C 1 -C 3 )alkanediyl group, and R'' is an optionally substituted phenyl group; R 2 is selected from the group consisting of a hydrogen atom and a (C 1 -C 3 )alkyl group; R 5 represents a hydrogen atom, a (C 1 -C 4 )alkyl group or a (C 3 -C 6 )cycloalkyl group or any of its pharmaceutically acceptable salt. The present invention further relates to a composition comprising a compound of formula (I) and a process for manufacturing said compound as well as its synthesis intermediates. It also relates to said compound for use as a medicament, in particular in the treatment and/or prevention of cognitive deficits and neuroinflammation associated with Down syndrome; Alzheimer's disease; dementia; tauopathies; Parkinson's disease; CDKL5 Deficiency Disorder; Phelan-McDermid syndrome; autism; type 1 and type 2 diabetes; abnormal folate and methionine metabolism; osteoarthritis and tendinopathy; Duchenne muscular dystrophy; cancers and leukemias; neuroinflammation, anemia, infections caused by unicellular parasites, viral infections and for regulating body temperature.

专利号:US-2004067531-A1
优先权日:1997-08-20
标 题:Methods of modulating protein tyrosine kinase function with substituted indolinone compounds
发明人：TANG PENG CHO; SUN LI; TRAN NGOC MY; NGUYEN ANH THI; NEMATALLA ASAAD
权利人:SUGEN INC
摘要:The invention relates to certain indolinone compounds, their method of synthesis, and a combinatorial library consisting of the indolinone compounds. The invention also relates to methods of modulating the function of protein tyrosine kinases using indolinone compounds and methods of treating diseases by modulating the function of protein tyrosine kinases and related signal transduction pathways.

专利号:US-8404670-B2
优先权日:2009-02-11
标题:Histamine H3 inverse agonists and antagonists and methods of use thereof
发明人：CHYTIL MILAN; ENGEL SHARON R; FANG QUN KEVIN; SPEAR KERRY L
权利人:CHYTIL MILAN; ENGEL SHARON R; FANG QUN KEVIN; SPEAR KERRY L; SUNOVION PHARMACEUTICALS INC
摘要:Provided herein are fused imidazolyl compounds, methods of synthesis, and methods of use thereof. The compounds provided herein are useful for the treatment, prevention, and/or management of various disorders, such as neurological disorders and metabolic disorders. Compounds provided herein inhibit the activity of histamine H3 receptors and modulate the release of various neurotransmitters, such as histamine, acetylcholine, norepinephrine, and dopamine (e.g. at the synapse). Pharmaceutical formulations containing the compounds and their methods of use are also provided herein.

专利号:EA-034084-B1
优先权日:2015-09-04
标 题:Pan-Genomic Protein Inhibitors of NS5A Hepatitis C Virus, Pharmaceutical Compositions, Intermediate Products for the Synthesis of Inhibitors and Methods for Their Production and Use