CAS: 3483-12-3; Cis-2,3-Dihydroxy-1,4-Butanedithiol

相似化合物

6892-68-8 16096-97-2 96-27-5

上下游产品

CAS号74185-01-6 oxidized DTT | CAS号50-81-7 抗坏血酸 | CAS号1086-80-2 7,8-二甲基咯嗪 | CAS号108-98-5 硫酚 | CAS号882-33-7 二苯二硫醚 | CAS号2197-57-1 1,4-Naphthalene... | CAS号86595-17-7 3-Hydroxy-2,3-d... | CAS号86595-15-5 2(S)-((2,3-thre...

专利信息

专利号:US-2010304368-A1
优先权日:2006-09-20
标 题:Components and method for enzymatic synthesis of nucleic acids
发明人：CHERKASOV DMITRY; BAEUML ENGLEBERT; BAEUML ELISABETH
权利人:CHERKASOV DMITRY; BAEUML ENGLEBERT; BAEUML ELISABETH
摘要:Novel methods for enzymatic synthesis of nucleic acid chains and the substrates for the same are disclosed. The methods are based on a step-wise enzymatic reaction. The sequencing of nucleic acids is an example of the use of the claimed methods.

专利号:US-7414106-B2
优先权日:2003-06-19
标 题 :Synthesis of peptide α-thioesters
发明人：CAMARERO JULIO A; MITCHELL ALEXANDER R; DE YOREO JAMES J
权利人:L LIVERMORE NAT SECURITY LLC
摘要:Disclosed herein is a new method for the solid phase peptide synthesis (SPPS) of C-terminal peptide α thioesters using Fmoc/t-Bu chemistry. This method is based on the use of an aryl hydrazine linker, which is totally stable to conditions required for Fmoc-SPPS. When the peptide synthesis has been completed, activation of the linker is achieved by mild oxidation. The oxidation step converts the acyl-hydrazine group into a highly reactive acyl-diazene intermediate which reacts with an α-amino acid alkylthioester (H-AA-SR) to yield the corresponding peptide α-thioester in good yield. A variety of peptide thioesters, cyclic peptides and a fully functional Src homology 3 (SH3) protein domain have been successfully prepared.

专利号:US-9382299-B2
优先权日:2011-09-09
标 题 :Polypeptides targeting glycosylated MUC2 proteins, methods of synthesis, their nucleic acids and uses thereof
发明人：MARTEYN BENOIT; COIC YVES-MARIE; BALEUX FRANCOISE; SANSONETTI PHILIPPE
权利人:MARTEYN BENOIT; COIC YVES-MARIE; BALEUX FRANCOISE; SANSONETTI PHILIPPE; PASTEUR INSTITUT
摘要:The invention relates to polypeptides, defined through a consensus sequence, having a length from 10 to 80 amino-acid residues, and whose polypeptidic sequence comprises or consists of the consensus sequence P1(X a )P3(X b )P5(X c )P6(X d )P7 (SEQ ID NO: 1), presenting specific patterns. The polypeptides of the invention target glycosylated Muc2 proteins. The invention also relates to methods of synthesis of such polypeptides, to their nucleic acids and uses thereof. The polypeptidic sequence of the polypeptides of the invention can be part of the N-terminal sequence of a mucus-binding (MUB) domain, especially a mucus-binding (MUB) domain of several species. The invention also relates to chimeric molecule(s) comprising such polypeptides, which are labelled, and vectors, especially plasmids and population of cells or composition comprising polypeptides of the invention. Synthesis methods encompass biotechnological or chemical production. Polypeptides of the invention can be used in staining experiments, as a probe or marker for staining Muc2 protein(s) contained in mucus layer(s), to detect in vitro mucus production or mucus composition in human colon or monitoring any one of the following disease conditions: neoplasic disease(s), including mucinous carcinoma(s), gastric cancer(s) or colorectal cancer(s), especially colon cancer(s), cystic fibrosis, intestine inflammatory disease(s) such as inflammatory bowel disease (IBD) and ulcerative colitis. The invention also relates to a method for manufacturing a medicament. In a particular embodiment, use of polypeptides of the invention can be made for marking neutrophiles.

专利号:US-7781488-B2
优先权日:2002-06-10
标 题:Post-cleavage sulfur deprotection for convergent protein synthesis by chemical ligation
发明人：BOTTI PAOLO; VILLAIN MATTEO; MANGANIELLO SONIA; GAERTNER HUBERT
权利人:AMYLIN PHARMACEUTICALS INC
摘要:The present invention provides a method and compositions for synthesizing an oligopeptide or polypeptide by convergent assembly of a plurality of pairs of oligopeptides in chemical ligation reactions. An important aspect of the present invention is an oligopeptide having a C-terminal disulfide-protected carboxythioester group that can be deprotected to spontaneously generate a free C-terminal thioester moiety. This allows a single precursor to participate in a succession of chemical ligation reactions, thereby making the convergent synthesis approach possible. The present invention is useful in methods for chemical synthesis of oligopeptides, polypeptides and proteins, and improves the efficiency of native chemical ligation reactions, particularly where four or more peptide fragments are used to assemble an oligopeptide, polypeptide or protein product.

专利号:WO-9405797-A1
优先权日:1992-09-01
标题 :Synthesis of dna molecules in vitro
发明人：KISELEV VSEVOLOD; SEVERIN EVGENII; KORPELA TIMO
权利人:KISELEV VSEVOLOD; SEVERIN EVGENII; KORPELA TIMO
摘要:The present invention is directed on a composition of thermophilic enzymes as a tool for DNA synthesis in vitro, the composition comprising, in combination, an enzyme being capable of carrying out the polymerization of dNTP to form de nova synthesized DNA molecules within the temperature interval of 56-90 °C (thermophilic DNA-polymerase) and an enzyme being capable of eliminating accumulated pyrophosphate (thermophilic pyrophosphatase) within the same temperature interval. The invention is also directed on the preparation and the use of the said composition.

专利号:US-7566697-B2
优先权日:2002-06-10
标题 :Carboxy protection strategies for acidic C-terminal amino acids in chemical ligation of oligopeptides
发明人：BOTTI PAOLO; VILLAIN MATTEO; MANGANIELLO SONIA; GAERTNER HUBERT
权利人:AMYLIN PHARMACEUTICALS INC
摘要:The present invention provides methods of assembling oligopeptides or polypeptides in a native chemical ligation reaction that eliminates the formation of unwanted side products resulting from the presence of an unprotected acidic C-terminal oligopeptide thioester. An important aspect of the present invention is providing side chain protected acidic C-terminal oligopeptide thioesters. The present invention is useful in methods for chemical synthesis of oligopeptides, polypeptides and proteins and improves the efficiency of native chemical ligation reactions, particularly where aspartyl or glutamyl peptide fragments are used to assemble an oligopeptide, polypeptide or protein product.