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CAS号88-72-2 邻硝基甲苯 | CAS号612-25-9 2-硝基苯甲醇 | CAS号631-61-8 乙酸铵 | CAS号85071-27-8 (2-nitrophenyl)... | CAS号612-23-7 邻硝基苄氯 | CAS号56-23-5 四氯化碳 | CAS号128-08-5 N-溴代丁二酰亚胺 | CAS号94-36-0 过氧化苯甲酰 | CAS号10549-96-9 9-[(2-nitrophen... | CAS号4403-69-4 2-氨基苄胺 | CAS号22162-51-2 1-(2-硝基苄基)吡咯-2-甲醛 | CAS号19577-82-3 1-methyl-4-[(2-... | CAS号189320-44-3 1-TERT-BUTYL 3-... | CAS号553-03-7 3,4-二氢-2(1H)-喹啉酮 | CAS号636-70-4 三乙胺氢溴酸盐 | CAS号95-20-5 2-甲基吲哚 | CAS号948-65-2 2-苯基吲哚 | CAS号29872-21-7 1-(iodomethyl)-...

甲基硝基苯置于三溴化磷体系中,化学反应生成2-硝基苄溴
参考文献:对光和过氧化氢具有双重响应的基于多肽的自修复水凝胶的制备和表征
标题:对光和过氧化氢具有双重响应的基于多肽的自修复水凝胶的制备和表征
摘要:可注射自愈水凝胶正在广泛应用于药物输送,组织工程等领域.由于其优异的生物相容性和生物降解性,多肽是制备可注射自修复水凝胶的理想候选者.本研究通过共聚4臂peg-胺,N-(对硝基苯氧基羰基)-L-蛋氨酸和n-(对硝基苯氧基羰基)-γ,获得了对过氧化氢和光具有双重响应的多肽基水凝胶.-邻硝基苄基-L-谷氨酸.由于肽段之间的疏水相互作用,水凝胶表现出可注射的自愈行为,肽段也充当疏水性药物分子的储存库.在过氧化氢存在下或在光照射下,蛋氨酸中的硫醚键被氧化为亚砜,而邻硝基苄酯键被断裂,形成谷氨酸.结果,多肽的相应疏水性嵌段变成亲水性的,加速了装载在多肽疏水性嵌段中的药物分子的释放.利用该技术,实现了疏水性药物分子的控制释放.我们的努力可以为制备基于对过氧化氢和光具有双重响应的多肽的自修复水凝胶提供新的策略.由此看来,多肽在药物递送,组织工程和其他领域的实际应用可以得到扩展和推进.
Doi:10.1039/d3Ra05156K

专利信息

专利号:WO-2024186075-A1
优先权日:2023-03-03
标题 :Synthesis method of antibody-drug conjugates using proximity effect-based site-selective antibody labeling
发明人：LEE HYUN SOO; KIM SOOIN; KWEON YONGSEOK
权利人:UNIV SOGANG RES & BUSINESS DEVELOPMENT FOUND; RESEARCH & BUSINESS FOUNDATION SUNGKYUNKWAN UNIV
摘要:The present invention relates to a method for the synthesis of an antibody-drug conjugate using proximity effect-based site-selective antibody labeling. Provided according to the present invention may be a method for the synthesis of an antibody-drug conjugate by site-selectively introducing a drug into an antibody using a pyridinium oxime derivative (labeling mediator protein) introduced into a binding protein containing a non-standard amino acid.

专利号:US-2024294455-A1
优先权日:2021-06-18
标 题:Synthesis of vinylated hydroxy esters with applicability in signal enhanced magnetic resonance imaging
发明人：GLÖGGLER STEFAN; KORCHAK SERGEY; JATAP ANIL P; SAUL PHILIP; MOLL DENIS
权利人:MAX PLANCK GESELLSCHAFT
摘要:The present invention relates to a method for preparing a compound suitable for signal enhanced magnetic resonance imaging comprising the steps of vinylating a mono-, di- or tricarboxylic acid comprising a moiety -Q-Z with Q being O or N and Z being a protecting group by using vinyl acetate, cleaving Z, and if Z has not already been converted into an alcohol upon cleavage, converting Q into an alcohol either by using nitrite or by converting Q into bromine followed by hydrolysis yielding a vinyl hydroxy ester. The compounds used may be partly or fully deuterated. Furthermore, the present invention relates to a vinyl hydroxy ester as well as an intermediate of its synthesis, wherein the vinyl moiety of the vinyl hydroxy ester and of the intermediate is partly or fully deuterated.

专利号:WO-2024174285-A1
优先权日:2023-02-21
标题:Method for preparing halogenated compound from metal halide salt on basis of mobile phase
发明人：SU REN; Ye Jiani
权利人:UNIV SOOCHOW
摘要:Disclosed is a method for preparing a halogenated compound from a metal halide salt on the basis of a mobile phase. The method comprises: converting an aromatic hydrocarbon, alkane or nitrile compound into a halogenated compound by means of a cheap metal halide salt and a photocatalyst under illumination. The method uses a cheap and safe halide salt as a halogen source, does not introduce additional elemental halogen or an additional oxidant, can implement a reaction at normal temperature and normal pressure, is high in terms of selectivity and friendly to environment, and can be used for replacing an existing synthesis reaction system for halogenated compounds. A mobile phase device is used to replace a tank reactor, such that operation is easy and convenient, the price is low, the substrate adaptability is high, the continuous synthesis of halogenated compounds can be achieved, and the method is suitable for industrial large-scale production.

专利号:US-9695109-B2
优先权日:2014-11-04
标题:Telescoping synthesis of 2-methoxymethyl-p-phenylenediamine
发明人：ABEL HEIKE GERTRUD; OSAN ARMIN; SPECKBACHER MARKUS; WEBER INGO REINHOLD; GARRETT GARRY STEVEN
权利人:NOXELL CORP
摘要:A telescoping process for the preparation of 2-methoxymethyl-p-phenylenediamine, a cosmetically acceptable salt thereof, or mixture thereof. The process according to the present invention is a particularly cost effective process in that it avoids sophisticated chemical steps which requires special equipment or expensive catalysts and in that it comprises a recycling step of one of the starting materials, namely 2-methoxymethylaniline.

专利号:US-8193392-B2
优先权日:2005-07-29
标 题:Method for enantioselective synthesis of phosphorus-stereogenic phosphines
发明人：SCRIBAN CORINA; GLUECK DAVID S
权利人:SCRIBAN CORINA; GLUECK DAVID S; DARTMOUTH COLLEGE
摘要:The present invention relates to a process for preparing an enantioenriched phosphorus-stereogenic, tertiary phosphine. Secondary phosphines are contacted with an alkyl halide and base in the presence of a chiral metal catalyst thereby producing the enantioenriched phosphorus-stereogenic, tertiary phosphine for subsequent use in homogeneous catalysis reactions.

专利号:US-2005192265-A1
优先权日:2003-03-20
标 题:Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting beta-amyloid peptide release and/or its synthesis by use of such compounds
发明人：THOMPSON RICHARD C; WILKIE STEPHEN; STACK DOUGLAS R; VANMETER ELDON E; SHI QING; BRITTON THOMAS C; AUDIA JAMES E; REEL JON K; MABRY THOMAS E; DRESSMAN BRUCE A; CWI CYNTHIA L; HENRY STEVEN S; MCDANIEL STACEY L; STUCKY RUSSELL D; PORTER WARREN J
摘要:Disclosed are compounds which inhibit β-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions that include a compound which inhibits β-amyloid peptide release and/or its synthesis as well as methods for treating Alzheimer's disease both prophylactically and therapeutically with such pharmaceutical compositions.