三氟甲苯置于甲醇,三氯化铁体系中,化学反应生成 3-(三氟甲基)苯甲醚 参考文献:Mcbee Et Al.,Journal Of The American Chemical Society,1947,Vol. 69,P. 946 标题:Mcbee Et Al.,Journal Of The American Chemical Society,1947,Vol. 69,P. 946
专利号:WO-2020242329-A1 优先权日:2019-05-30 标 题:Diketopyrrolopyrroles having three different substituents as emitters of yellow, orange and red light, and the method of their preparation 发明人:PIECZYKOLAN MICHAÅ?; GRYKO DANIEL 权利人:INST CHEMIII ORGANICZNEJ PAN 摘要:New derivatives of diketopyrrolopyrroles (well-known organic pigments) having three different substituents and a new method of obtaining them have been disclosed. These dyes can be used as highly fluorescent substances with advantageous properties. These compounds can be obtained by the method according to the invention in no more than a four-step synthesis from simple, readily available and cheap substrates.
专利号:US-12336981-B2 优先权日:2010-09-03 标题 :Compounds and compositions for the inhibition of NAMPT 发明人:BAIR KENNETH W; BAUMEISTER TIMM R; BUCKMELTER ALEXANDRE J; CLODFELTER KARL H; DRAGOVICH Peter; GOSSELIN FRANCIS; HAN BINGSONG; LIN JIAN; REYNOLDS DOMINIC J; ROTH BRUCE; SMITH CHASE C; WANG ZHONGGUO; YUEN PO-WAI; ZHENG XIAOZHANG 权利人:VALO HEALTH INC; GENENTECH INC 摘要:The present invention relates to compounds and compositions for the inhibition of NAMPT, their synthesis, applications, and antidotes. An illustrative compound of the invention is shown below:
专利号:US-5220074-A 优先权日:1990-01-25 标 题:Optically active isoxazole derivatives and intermediates for preparation thereof as well as processes for producing the same 发明人:TAKAHASHI TAKASHI; SAKAGUCHI KAZUHIKO 权利人:DAISO CO LTD 摘要:The present invention relates to novel optically active isoxazole derivatives represented by general formula: ##STR1## which are useful as intermediates for synthesis of prostaglandin and a process for producing the same as well as novel aldehyde compounds represented by general formula: ##STR2## which are intermediates for preparing the compounds [XI] described above and a process for preparation thereof. In the compounds shown by these formulae, R 1 represents an alkyl group or a cycloalkyl group which may have an alkoxy group or a group shown by -Ra-A-B (wherein Ra is an alkyl group; A is a hetero atom or an single bond; and B is an aromatic or hetero ring which may have a substituent(s)); and R 2 and R 3 , which may be the same or different, each represents an aralkyl group, a silyl group or an acyl group.
专利号:US-5231208-A 优先权日:1987-06-16 标 题:Substituted cyclic ketones, substituted cyclic enones, and process for producing the same 发明人:SATO FUMIE; ARAI KAZUTAKA; MIYAJI KATSUAKI 权利人:NISSAN CHEMICAL IND LTD 摘要:The present invention relates to substituted cyclopentanone and cyclohexanone derivatives and substituted cyclopentenone and cyclohexenone derivatives, which are useful as intermediates for pharmaceutical products and agricultural chemicals and especially useful for the synthesis of prostaglandins, and also to a process for producing the same.
专利号:US-5210201-A 优先权日:1990-01-25 标题:Optically active isoxazole derivatives and intermediates for preparation thereof as well as processes for producing the same 发明人:TAKAHASHI TAKASHI; SAKAGUCHI KAZUHIKO 权利人:DAISO CO LTD 摘要:The present invention relates to novel optically active isoxazole derivatives represented by general formula: ##STR1## which are useful as intermediates for synthesis of prostaglandin and a process for producing the same as well as novel aldehyde compounds represented by general formula: ##STR2## which are intermediates for preparing the compounds [XI] described above and a process for preparation thereof. In the compounds shown by these formulae, R 1 represents an alkyl group or a cycloalkyl group which may have an alkoxy group or a group shown by --Ra--A--B (wherein Ra is an alkyl group; A is a hetero atom or an single bond; and B is an aromatic or hetero ring which may have a substituent(s)); and R 2 and R 3 , which may be the same or different, each represents an aralkyl group, a silyl group or an acyl group.
专利号:US-5227505-A 优先权日:1987-06-16 标题:Substituted cyclic ketones, substituted cyclic enones, and process for producing the same 发明人:SATO FUMIE; ARAI KAZUTAKA; MIYAJI KATSUAKI 权利人:NISSAN CHEMICAL IND LTD 摘要:The present invention relates to substituted cyclopentanone and cyclohexanone derivatives and substituted cyclopentenone and cyclohexenone derivatives, which are useful as intermediates for pharmaceutical products and agricultural chemicals and especially useful for the synthesis of prostaglandins, and also to a process for producing the same.
摘要:Hall, D. G.; Zheng, H., Science of Synthesis Knowledge Updates, (2011) 4, 73. 摘要:Ros, A.; Fernández, R.; Lassaletta, J. M., Science of Synthesis: Catalytic Transformations via CH Activation, (2015) 2, 408. 摘要:Wu, S.; Song, H.; Hu, M., Science of Synthesis: Modern Strategies in Organofluorine Chemistry , (2024) 1, 65. 参考文献:10.1038/ncomms14190 摘要:Meng Q, Hou M, Liu H, Song J, Han B. Synthesis of ketones from biomass-derived feedstock. Nature Communications. 2017 Jan 31;8(1):14190. doi: 10.1038/ncomms14190.