CAS: 51856-79-2; Methyl 2-(1-Methyl-1H-Pyrrol-2-yl)Acetate

相似化合物

61380-25-4 21898-59-9 878629-83-5

上下游产品

N-Methylpyrrole methyl 2-iodoacetate dimethyl diazomalonate 1-methyl-2-(2',2',2'-trichloro-1'-hydroxyethyl)pyrrole(5-benzoyl-1-methyl-1H-pyrrol-2-yl)acetic acid methyl ester acetatemethyl 2-1-methyl-5-(p-chlorobenzoyl)-pyrrroleacetate methyl 1-methyl-5-(4-methoxybenzoyl)pyrrole-2-acetate H-pyrrol-2-yl]-acetic acid methyl ester[5-(4-acetylamino-benzoyl)-1-methyl-1H-pyrrol-2-yl]-acetic acid methyl ester

N-甲基吡咯置于对甲苯磺酸,一水合肼,Potassium Hydroxide体系中,用 二氯甲烷,水 作为反应溶剂,化学反应 18.0H,反应生成 1-甲基-2-吡咯乙酸甲酯
参考文献:1,5-二氮杂双环[4.3.0] Non-5-Ene(dbn)用作亲核催化剂的friedel-Crafts吡咯和吲哚酰化反应
标题:1,5-二氮杂双环[4.3.0] Non-5-Ene(dbn)用作亲核催化剂的friedel-Crafts吡咯和吲哚酰化反应
摘要:1,5-二氮杂双环[4.3.0] Non-5-Ene(dbn)已被证明是一种高产率的吡咯和吲哚的区域选择性friedel-Crafts C-酰化反应的有效催化剂.详细的机理研究表明,Dbn充当亲核有机催化剂,首次确定了关键的n-酰基-Idine中间体的x射线晶体结构.
DOI:10.1021/ol1025348

专利信息

专利号:US-6531477-B1
优先权日:1998-10-13
标 题:6-substituted pyrazolo [3,4-d] pyrimidin-4-ones useful as cyclin dependent kinase inhibitors
发明人：MARKWALDER JAY A; SEITZ STEVEN P; SHERK SUSAN R
权利人:DU PONT PHARM CO
摘要:The present invention relates to the synthesis of a novel class of pyrazolo[3,4-d]pyrimidin-4-ones of formula (I), alternatively represented by the tautomer (II):that are potent inhibitors of the class of enzymes known as cyclin dependent kinases, which relate to the catalytic subunits cyclin dependent kinase 1-8 and their regulatory subunits know as cyclins A-H, K, N, and T.This invention also provides a novel method of treating cancer or other proliferative diseases by administering a therapeutically effective amount of one of these compounds or a pharmaceutically acceptable salt form thereof. Alternatively, one can treat cancer or other proliferative diseases by administering a therapeutically effective combination of one of the compounds of the present invention and one or more other known anti-cancer or anti-proliferative agents.

专利号:US-6559152-B2
优先权日:1998-10-13
标 题 :6-substituted pyrazolo[3,4-d]pyrimidin-4-ones useful as cyclin dependent kinase inhibitors
发明人：MARKWALDER JAY A; SEITZ STEVEN P; SHERK SUSAN R
权利人:DU PONT PHARM CO
摘要:The present invention relates to the synthesis of a novel class of pyrazolo[3,4-d]pyrimidin-4-ones of formula (I), alternatively represented by the tautomer (II):that are potent inhibitors of the class of enzymes known as cyclin dependent kinases, which relate to the catalytic subunits cyclin dependent kinase 1-8 and their regulatory subunits know as cyclins A-H, K, N, and T.This invention also provides a novel method of treating cancer or other proliferative diseases by administering a therapeutically effective amount of one of these compounds or a pharmaceutically acceptable salt form thereof. Alternatively, one can treat cancer or other proliferative diseases by administering a therapeutically effective combination of one of the compounds of the present invention and one or more other known anti-cancer or anti-proliferative agents.

专利号:US-2009227801-A1
优先权日:2004-10-26
标 题 :Ligands for use in asymmetric hydroformylation
发明人：AHLERS WOLFGANG; EGEN MARTINA; VOLLAND MARTIN; JAKEL CHRISTOPH; HETTCHE FRANK; PACIELLO ROCCO
权利人:BASF AG
摘要:The invention relates to chiral phosphorus chelate compounds, to catalysts comprising such a compound such a compound as the ligand, and to asymmetric synthesis methods in the presence of such a catalyst.