专利号:US-8153839-B2 优先权日:2005-09-14 标题:Method for synthesis of keto acids or amino acids by hydration of acetylene compound 发明人:OGO SEIJI; FUKUZUMI SHUN-ICHI 权利人:OGO SEIJI; FUKUZUMI SHUN-ICHI; JAPAN SCIENCE & TECH AGENCY 摘要:An object of the present invention is to provide a method for synthesis of keto acids by hydration of an acetylene compound (acetylene-carboxylic acids) under mild conditions free from harmful mercury catalysts and a method for synthesis of amino acids from acetylene-carboxylic acids in a single container (one-pot or tandem synthesis). In one embodiment of the method according to the present invention for synthesis of keto acids, acetylene-carboxylic acids is hydrated in the presence of a metal salt represented by General Formula (1), n nwhere M 1 represents an element in Group VIII, IX, or X of the periodic table, and X 1 , X 2 , or X 3 ligand represents halogen, H 2 O, or a solvent molecule, and k represents a valence of a cation species, and Y represents an anion species, and L represents a valence of the anion species, and each of K and L independently represents 1 or 2, and k×m=L×n.
专利号:US-8580949-B2 优先权日:2009-07-27 标题:Enzymatic synthesis of carba-NAD 发明人:DUEFEL HARTMUT; HEINDL DIETER; HORN CARINA; MEIER THOMAS; SCHMUCK RAINER 权利人:DUEFEL HARTMUT; HEINDL DIETER; HORN CARINA; MEIER THOMAS; SCHMUCK RAINER; ROCHE DIAGNOSTICS OPERATIONS 摘要:The disclosure concerns the enzymatic synthesis of stable analogues of nicotinamide adenine dinucleotide NAD/NADH and nicotinamide adenine dinucleotide phosphate NADP/NADPH, the so-called “carba-NADsâ€?, i.e. analogues of NAD/NADH or NADP/NADPH, respectively, comprising a carbacyclic sugar instead of ribose.
专利号:US-7109377-B2 优先权日:1996-10-16 标 题:Synthesis of combinatorial libraries of compounds reminiscent of natural products 发明人:SCHREIBER STUART L; SHAIR MATTHEW D; TAN DEREK S; FOLEY MICHAEL A; STOCKWELL BRENT R 权利人:HARVARD COLLEGE 摘要:The present invention provides complex compounds reminiscent of natural products and libraries thereof, as well as methods for their production. The inventive compounds and libraries of compounds are reminiscent of natural products in that they contain one or more stereocenters, and a high density and diversity of functionality. In general, the inventive libraries are synthesized from diversifiable scaffold structures, which are synthesized from readily available or easily synthesizable template structures. In certain embodiments, the inventive compounds and libraries are generated from diversifiable scaffolds synthesized from a shikimic acid based epoxyol template. In other embodiments, the inventive compounds and libraries are generated from diversifiable scaffolds synthesized from the pyridine-based template isonicotinamide. The present invention also provides a novel ortho-nitrobenzyl photolinker and a method for its synthesis. Furthermore, the present invention provides methods and kits for determining one or more biological activities of members of the inventive libraries. Additionally, the present invention provides pharmaceutical compositions containing one or more library members.
专利号:US-2014296354-A1 优先权日:2013-04-01 标题 :Synthesis of peptoid-based small molecular gelators from multiple component reactions 发明人:WANG GUIJUN; MANGUNURU HARI P R 权利人:WANG GUIJUN; MANGUNURU HARI P R; OLD DOMINION UNIV RES FOUND 摘要:Described herein are the one-pot synthesis and characterization of a library of low molecular weight peptoid compounds that are able to form gels at room temperature. The compounds are synthesized from biologically-based starting materials, are biocompatible, and are resistant to degradation by proteases and peptidases. The compounds and gels synthesized therefrom can be used in such applications as tissue engineering, drug delivery, separation of biomolecules, and stimulus-responsive advanced materials
专利号:US-8563760-B2 优先权日:2009-08-31 标 题:Process for the synthesis of long-chain fatty acids 发明人:FAUQ ABDUL H; EDWARDS ALBERT O 权利人:FAUQ ABDUL H; EDWARDS ALBERT O; MAYO FOUNDATION 摘要:This invention relates to processes for preparing long-chain fatty acids of Formula I: n nand salts thereof, as well as intermediates for the processes, wherein L 1 and L 2 are described herein.
专利号:US-6107508-A 优先权日:1998-04-03 标 题 :Convergent synthesis of α-aryl-β-ketonitriles 发明人:ZHOU JIACHENG; OH LYNETTE MAY; MA PHILIP 权利人:DU PONT PHARM CO 摘要:The present invention relates to processes for the production of alpha -aryl- beta -ketonitriles, which serve as synthetic intermediates in the preparation of a series of biologically important molecules such as corticotropin releasing factor (CRF) receptor antagonists.
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合成参考文献
摘要:Kwiecień, H., Science of Synthesis Knowledge Updates, (2014) 4, 331. 摘要:Tomé, A. C., Science of Synthesis Knowledge Updates, (2015) 2, 99. 摘要:Lee, C.-F., Science of Synthesis Knowledge Updates, (2019) 3, 95. 摘要:Cheng, B.; Wang, T., Science of Synthesis Knowledge Updates, (2020) 3, 192. 摘要:Singh, F. V., Science of Synthesis Knowledge Updates, (2021) 1, 162.