专利号:WO-2024084510-A1 优先权日:2022-10-20 标题 :Glutamic acid independent process for synthesis of poly gamma glutamic acid 发明人:DHARNE MAHESH SHANTAPPA; NAIR PRANAV GIRIJAVALLABHAN 权利人:COUNCIL OF SCIENT AND INDUSTRIAL RESEARCH AN INDIAN REGISTERED BODY INCORPORATED UNDER THE REGN OF S 摘要:The present invention relates to a cost-effective process for the synthesis of hyper-production of poly gamma glutamic acid using L-glutamic acid independent approach. Specifically, the present invention relates to the synthesis of poly gamma glutamic acid (γ-PGA) from jaggery, blackstrap molasses, and floral waste. More particularly, the present invention relates to a process for the synthesis of poly gamma glutamic acid in high yield and in the presence of Bacillus paralicheniformis NCIM 5769.
专利号:US-2009326281-A1 优先权日:2008-06-30 标题:Catalytic system and process for direct synthesis of dimethyl ether from synthesis gas 发明人:APPEL LUCIA GORENSTIN; DE FARIAS ANDREA MARIA DUARTE; ESTEVES ANGELA MARIA LAVOGADE; FRAGA MARCO ANDRE; RAMOS BARBOSA FLAVIA DE SOUZA; BORGES LUIZ EDUARDO PIZZARO; MONTEIRO JOSE LUIZ FONTES; HUERTAS FLORES JHONNY OSWALDO; DA SILVA MARIA ISABEL PAIS; SOUSA AGUIAR EDUARDO FALABELLA 权利人:PETROLEO BRASILEIRO SA; INT INST NAC DE TECNOLOGIA 摘要:A mixed-bed catalytic system and its activation for direct synthesis of dimethyl ether from synthesis gas are described, comprising a catalyst for methanol synthesis and the zeolite ferrierite in its acid form as the methanol dehydrating component, the two being mixed physically in the form of powder of defined granulometry or as pellets. Another object of the present invention is a process for production of the acid form of the zeolite ferrierite. Another object of the present invention is a process for direct synthesis of dimethyl ether from a synthesis gas, using the catalytic system of the present invention.
专利号:US-2007259917-A1 优先权日:2006-04-24 标题 :Processes for the synthesis of 3-isobutylglutaric acid 发明人:KANSAL VINOD K; CHAURASIA BRIJNATH P; PATEL HITESH K; SHELKE SHIVAJI H; MORE YOGESH P 权利人:KANSAL VINOD K; CHAURASIA BRIJNATH P; PATEL HITESH K; SHELKE SHIVAJI H; MORE YOGESH P 摘要:Provided are processes for the synthesis of 3-isobutylglutaric acid, an intermediate in the synthesis of (S)-Pregabalin.
专利号:WO-2024036115-A1 优先权日:2022-08-08 标题:Continuous flow synthesis of lorazepam 发明人:THOMPSON DAVID; BIYANI SHRUTI; HYUN SEOK-HEE; MCGUIRE MICHAEL 权利人:PURDUE RESEARCH FOUNDATION; CONTINUITY PHARMA LLC 摘要:A method for synthesis of Lorazepam in a continuous flow using continuous flow reactor, in which method comprises five steps including N-acylation, diazepine ring closure, imine N- oxidation, Polonovski-type rearrangement, and ester hydrolysis; a green reagent comprising a peroxide reagent and rhenium oxide catalyst for N-oxidation of delorazepam; and an ammonium source combination for the synthesis of delorazepam.
专利号:US-6028237-A 优先权日:1996-12-16 标题:Synthesis of cyclopropylacetylene 发明人:PARSONS JR RODNEY LAWRENCE 权利人:DU PONT PHARM CO 摘要:The present invention relates generally to novel methods for the synthesis of cyclopropylacetylene which is a reagent in the asymmetric synthesis of (S)-6-chloro-4-cyclopropylethynyl-4-trifluoromethyl-1,4-dihydro-2H-3,1-benzoxazin-2-one which is a useful human immunodeficiency virus (HIV) reverse transcriptase inhibitor.
专利号:US-2023174567-A1 优先权日:2020-05-22 标题:Synthesis of fluorinated nucleotides 发明人:ARMIGER TRAVIS; BELYK KEVIN M; BENKOVICS TAMAS; CHUNG CHEOL K; JI CHEN YINING; JOHNSON HEATHER CLAIRE; KLAPARS ARTIS; LIU ZHIJIAN; LIU ZHUQING; MOORE JEFFREY C; NEEL ANDREW J; PENG FENG; RUMMELT STEPHAN M; SALEHI MARZUARANI NASTARAN; SHERRY BENJAMIN D; SONG ZHIGUO JAKE; TURNBULL BEN WILLIAM HULME; WANG LU; XU FENG 权利人:MERCK SHARP & DOHME LLC 摘要:The present invention relates to efficient processes useful in the preparation of fluorinated nucleosides, such as (2S,3R,4S,5R)-5-(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)-3-fluoro-4-hydroxy-2-(mercaptomethyl)tetrahydrofuran-3-yl dihydrogen phosphate, also known as 3′-fluoro-thio-guanosine monophosphate or 3′-F-thio-GMP. Such fluorinated nucleosides may be useful as a biologically active compound and or as an intermediate for the synthesis of more complex biologically active compounds. The present invention also encompasses intermediates useful in the disclosed synthetic processes and the methods of their preparation. (I)
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