CAS: 6941-75-9; 5-Bromoisoindoline-1,3-Dione

上下游产品

CAS号86-90-8 4-溴邻苯二甲酸酐 | CAS号106701-82-0 4-bromophthalic... | CAS号3676-85-5 4-氨基邻苯二甲酰亚胺 | CAS号6968-28-1 4-溴邻苯二甲酸 | CAS号827-27-0 邻苯二甲酸氢钠 | CAS号57-13-6 尿素 | CAS号90224-73-0 4-溴-N-甲基邻苯二甲酰亚胺 | CAS号912999-49-6 奥那司匹 | CAS号905273-91-8 N-B°C-异吲哚啉-5-硼酸频哪醇酯 | CAS号919346-89-7 5-溴异二氢吲哚盐酸盐 | CAS号127168-84-7 5-溴异二氢吲哚 | CAS号206268-72-6 4-溴-5-硝基-1,2-苯二甲腈 | CAS号20776-50-5 2-氨基-4-溴苯甲酸 | CAS号5794-88-7 2-氨基-5-溴苯甲酸 | CAS号70484-01-4 4-溴邻苯二甲胺 | CAS号75884-70-7 6-溴-2,3-二氮杂萘酮

4-溴邻苯二甲酸置于硫氰酸铵体系中,化学反应 0.17H,以84%的收率获得产物4-溴邻苯二甲酰亚胺
参考文献:四(二乙基膦基)-,四(乙基苯基膦基)-和四(二苯基膦基氧化物)-取代酞菁
标题:四(二乙基膦基)-,四(乙基苯基膦基)-和四(二苯基膦基氧化物)-取代酞菁
摘要:四(膦酸二乙酯),四(苯基次膦酸乙酯)和四(二苯基膦氧化物)取代的酞菁
DOI:10.1002/hlca.200490081

专利信息

专利号:US-RE41614-E
优先权日:1998-09-30
标题 :Synthetic analogs of ecteinascidin-743
发明人：COREY ELIAS J
权利人:HARVARD COLLEGE
摘要:The present invention is directed to the synthesis and characterization of compounds having the formula: n n wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 and R 9 are each independently selected from the group consisting of H, OH, OR′, SH, SR′, SOR′, SO 2 R′, NO 2 , NH 2 , NHR′, N(R′) 2 , NHC(â•?O)R′ NHC( â•?O ) R′ , CN, halogen, â•?O, C(â•?O)H, C(â•?O)R′, CO 2 H, CO 2 R′, C 1 -C 12 alkyl, C 2 -C 12 alkenyl, C 2 -C 12 alkynyl, substituted or unsubstituted aryl, substituted or unsubstituted aralkyl, and substituted or unsubstituted heteroaromatic; wherein each of the R′ groups is independently selected from the group consisting of H, OH, NH 2 , NO 2 , SH, CN, halogen, â•?O, C(â•?O)H, C(â•?O)CH 3 , CO 2 H, CO 2 CH 3 , C 1 -C 12 alkyl, C 2 -C 12 alkenyl, C 2 -C 12 alkynyl, aryl, aralkyl, and heteroaromatic; wherein each dotted circle represents one, two or three optional double bonds; wherein R 7 and R 8 may be are joined into a carbocyclic or heterocyclic ring system; and wherein X 1 and X 2 are each independently defined as above for R 1 -R 8 R 1 - R 6 and R 9 , an each further includes specific preferred groups as defined herein.

专利号:US-10112955-B2
优先权日:2015-10-29
标题 :Isoindoline, azaisoindoline, dihydroindenone and dihydroazaindenone inhibitors of Mnk1 and Mnk2
发明人：SPRENGELER PAUL A; REICH SIEGFRIED H; ERNST JUSTIN T; WEBBER STEPHEN E; SHAGHAFI MIKE; MURPHY DOUGLAS; TRAN CHINH
权利人:EFFECTOR THERAPEUTICS INC
摘要:The present invention provides synthesis, pharmaceutically acceptable formulations and uses of compounds in accordance with Formula I, or a stereoisomer, tautomer or pharmaceutically acceptable salt thereof. n nFor Formula I compounds A 1 , A 2 , A 3 , A 4 , A 5 , W 1 , Y, R 1 , R 2 , R 3 , R 4 , R 5 , R 6a , R 6b , R 7 , R 8 , R 8a , R 8b , R 9 , R 9a , R 9b , and R 10 and subscript “nâ€? are as defined in the specification. The inventive Formula I compounds are inhibitors of Mnk and find utility in any number of therapeutic applications, including but not limited to treatment of inflammation and various cancers.

专利号:US-6569859-B1
优先权日:2000-02-22
标题 :Synthetic analogs of ecteinascidin-743
发明人：COREY ELIAS J
权利人:HARVARD COLLEGE
摘要:The present invention is directed to the synthesis and characterization of compounds having the formula: n wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 and R 9 are each independently selected from the group consisting of H, OH, OR′, SH, SR′, SOR′, SO 2 R′, NO 2 , NH 2 , NHR′, N(R′) 2 , NHC(O)R′, CN, halogen, â•?O, C(â•?O)H, C(â•?O)R′, CO 2 H, CO 2 R′, C 1 -C 12 alkyl, C 2 -C 12 alkenyl, C 2 -C 12 alkynyl, substituted or unsubstituted aryl, substituted or unsubstituted aralkyl, and substituted or unsubstituted heteroaromatic; n wherein each of the R′ groups is independently selected from the group consisting of H, OH, NH 2 , NO 2 , SH, CN, halogen, â•?O, C(â•?O)H, C(â•?O)CH 3 , CO 2 H, CO 2 CH 3 , C 1 -C 12 alkyl, C 2 -C 12 alkenyl, C 2 -C 12 alkynyl, aryl, aralkyl, and heteroaromatic; n wherein each dotted circle represents one, two or three optional double bonds; n wherein R 7 and R 8 may be joined into a carbocyclic or heterocyclic ring system; and n wherein X 1 and X 2 are each independently defined as above for R 1 -R 8 , and each furher includes specific preferred groups as defined herein.

专利号:US-8404670-B2
优先权日:2009-02-11
标题:Histamine H3 inverse agonists and antagonists and methods of use thereof
发明人：CHYTIL MILAN; ENGEL SHARON R; FANG QUN KEVIN; SPEAR KERRY L
权利人:CHYTIL MILAN; ENGEL SHARON R; FANG QUN KEVIN; SPEAR KERRY L; SUNOVION PHARMACEUTICALS INC
摘要:Provided herein are fused imidazolyl compounds, methods of synthesis, and methods of use thereof. The compounds provided herein are useful for the treatment, prevention, and/or management of various disorders, such as neurological disorders and metabolic disorders. Compounds provided herein inhibit the activity of histamine H3 receptors and modulate the release of various neurotransmitters, such as histamine, acetylcholine, norepinephrine, and dopamine (e.g. at the synapse). Pharmaceutical formulations containing the compounds and their methods of use are also provided herein.

专利号:RU-2074180-C1
优先权日:1993-02-01
标 题:6(7)-halogen-1,3,3-trichloroisoindolenins as intermediate products for synthesis of dihalogen-substituted phthalocyanines or their complexes

专利号:WO-2025088073-A1
优先权日:2023-10-24
标 题:Heterocyclic compounds as blt2 agonists and their medical use
发明人：HERNANDEZ-OLMOS VICTOR; HEERING JAN; PROSCHAK EUGEN; STEINHILBER DIETER; WEIGERT ANDREAS
权利人:FRAUNHOFER GES FORSCHUNG; JOHANN WOLFGANG GOETHE UNIV FRANKFURT AM MAIN
摘要:[1] Herein, novel compounds of formula (III) that act as selective agonists of the leukotriene B4 receptor 2 (BLT2) receptor are presented. The invention pertains to these compounds, their synthesis, as well as their medical use, amongst others in the treatment of pain and inflammatory skin diseases such as psoriasis.