CAS: 1197-09-7; 1-(3,4-Dihydroxyphenyl)Ethan-1-One

该化合物是一种酚类氯酮化合物,其特征是三尺四寸位置与苯环相连的两个羟基基酮组,这种结构具有重要的回活动性,使其成为有机合成中的宝贵中间体,特别是生产药品,农用化学品和特殊化学品,其二氢氧代用在氧化性联结反应中的效用和作为氟氯素和其他生物活性分子的前体.该化合物在极地有机溶剂中表现出中等溶解性,便于其在各种反应条件下使用.其定义明确的化学特性和在受管制条件下的稳定性使它成为研究和工业应用的可靠选择.

结构式图片

相似化合物

7451-98-1 139-85-5 13494-10-5

欧盟法规

ECHA物质C&L通报

上下游产品

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合成工艺路线路线简述

    对羟基苯乙酮置于双氧水体系中,用 乙腈 用作溶剂,化学反应生成3,4-二羟基苯乙酮
    参考文献:光致反应-xxxv:过氧化氢在乙腈中的光分解使酚类羟基化
    标题:光致反应-xxxv:过氧化氢在乙腈中的光分解使酚类羟基化
    摘要:通过过氧化氢的光分解,发现乙腈是制备各种苯酚的规模水垢羟化反应的最佳有机溶剂.用2537å的光照射系统,形成了邻位和对位二羟基化合物的主要产物.通过与对甲酚的竞争反应研究了代表性取代酚的相对反应性和酚对过氧化氢分解速率的影响.发现苯酚的表观反应性按以下顺序降低.P-Ph> P-Ac,P-Me,P-Cl> P-Cooh,O-No2,P-Cn,P-吨-Bu>米-Cooh,P-No 2 > 2,4-(coome)2 >-2,4(no 2)2.对过氧化氢的分解速度的影响倾向于以相同的顺序降低,但是没有发现明显的关系.讨论了将oh自由基加到苯酚中的机理.
    Doi:10.1016/0040-4020(70)85026-8

    海关参考信息

    专利信息


    专利号:US-6818394-B1
    优先权日:1996-11-06
    标题:High density immobilization of nucleic acids
    发明人:O'DONNELL-MALONEY MARYANNE J; CANTOR CHARLES R; KOESTER HUBERT
    权利人:SEQUENOM INC
    摘要:Processes and kits for immobilizing a high density of nucleic acids on an insoluble surface, which are particularly useful for mass spectrometric detection of nucleic acids, are disclosed. Arrays containing the immobilized nucleic acids and use of the immobilized nucleic acids in a variety of solid phase nucleic acid chemistry applications, including nucleic acid synthesis (chemical and enzymatic), hybridization and/or extension, and sequencing, are provided. Serial and parallel dispensing tools that can deliver defined volumes of fluid to generate multi-element arrays of sample material on a substrate surface are further provided. Tools provided herein can include an assembly of vesicle elements, or pins, wherein each of the pins can include a narrow interior chamber suitable for holding nanoliter volumes of fluid. Methods for dispensing tools that can be employed to generate multi-element arrays of sample material on a substrate surface are also provided. The tool can dispense a spot of fluid to a substrate surface by spraying the fluid from the pin, contacting the substrate surface or forming a drop that touches against the substrate surface. The tool can form an array of sample material by dispensing sample material in a series of steps, while moving the pin to different locations above the substrate surface to form the sample array, The prepared sample arrays may be passed to a plate assembly that disposes the sample arrays for analysis by mass spectrometry.

    专利号:NZ-330610-A
    优先权日:1994-01-21
    标题 :Use of aminoguanidine derivatives to inhibit synthesis of urea from plasma arginine

    专利号:CN-111808902-B
    优先权日:2019-04-10
    标题 :C-glycosyltransferase and application thereof in synthesis of schaftoside and isoschaftoside

    专利号:CN-105461527-A
    优先权日:2015-12-24
    标 题 :Synthesis method of efloxate drug intermediate 3, 4-dihydroxyacetophenone

    专利号:US-7427690-B2
    优先权日:2004-06-05
    标 题 :Multifunction “crown complexesâ€? from amino acids and peptides for skin and hair restoration
    发明人:GUPTA SHYAM K
    权利人:BIODERM RESEARCH
    摘要:This invention relates to Schiff's bases derived from amino acids and hydroxyaryl alkyl ketones, or a plant extract containing the same, having general chemical structure in FIG. 1 for topical application. This invention also relates to certain metal complex of said Schiff's bases, which have a crown-like appearance in their three-dimensional chemical structure, as in FIG. 2 . The Schiff's bases and their metal complexes of the present invention are useful for the modulation of metal-activated enzymes and metalloenzymes, such as Phenylalanine Hydroxylase, Tyrosine Transaminase, Phenylalanine Transaminase, Tyrosinase, various MMP (Matrix metalloproteases), Superoxide dismutase, 5-Alpha Reductase, and citrate lyase. These are further suitable for multifunctional topical methods for skin whitening, skin wrinkles reduction, skin antiaging, collagen synthesis, acne control, hair loss prevention, hair graying control, and facial oil control.
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    主要参考文献

    [参考文献]: Xiao Ruan, Et Al. Autotoxicity And Allelopathy Of 3,4-Dihydroxyacetophenone Isolated From Picea Schrenkiana Needles. Molecules. 2011 Oct 24;16(10):8874-93.
    [参考文献]: You Jung Kim, Et Al. Antimelanogenic Activity Of 3,4-Dihydroxyacetophenone: Inhibition Of Tyrosinase And Mitf. Biosci Biotechnol Biochem. 2006 Feb;70(2):532-4.

    合成参考文献


    摘要:Wu, F.; Zhu, S., Science of Synthesis Knowledge Updates, (2020) 1, 164.
    摘要:Li, D.-D.; Wang, G.-W., Science of Synthesis: Catalytic Transformations via CH Activation, (2015) 2, 355.
    摘要:Sun YP. [Effect of 3,4-dihydroxyacetophenone on platelet aggregation in normal pregnancy and pregnancy induced hypertension]. Zhonghua Fu Chan Ke Za Zhi. 1992 Jan;27(1):9–11, 57.
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