CAS: 30766-22-4; Methyl 5-Hydroxynicotinate

相似化合物

89937-78-0 27828-71-3 1060804-48-9

上下游产品

CAS号67-56-1 甲醇 | CAS号27828-71-3 5-羟基烟酸 | CAS号29681-44-5 5-溴烟酸甲酯 | CAS号455-70-9 5-氟吡啶-3-甲酸甲酯 | CAS号4591-55-3 3,5-吡啶二甲酸甲酯 | CAS号263270-34-4 5-苄氧基烟酸 | CAS号20826-03-3 5-甲氧基烟酸 | CAS号1095010-47-1 1-B°C-5-羟基-3-哌啶甲酸甲酯 | CAS号1095010-44-8 5-羟基-3-哌啶甲酸甲酯 | CAS号1095010-48-2 1-B°C-5-羟基-3-哌啶甲酸 | CAS号298204-74-7 5-甲氧基烟腈 | CAS号26218-80-4 6-甲氧基烟酸甲酯 | CAS号29681-46-7 5-甲氧基-3-吡啶羧酸甲酯

Methyl 5-Benzyloxy-4-Chloronicotinate置于palladium On Activated Charcoal 氢气体系中,用 甲醇,水,N,N-二甲基甲酰胺 作为反应溶剂,化学反应 0.67H,以77%的收率获得产物5-羟基烟酸甲酯
参考文献:用于潜在糖苷酶抑制剂的三种新型支架的合成途径
标题:用于潜在糖苷酶抑制剂的三种新型支架的合成途径
摘要:开发了用于潜在 β-糖苷酶抑制剂的三种新型支架的有效合成:第一种由 2,7-二氧杂双环 [2.2.1] 庚烷衍生物组成,该衍生物通过分子内缩酮化制备.第二个支架由羟基化环戊胺组成,可以立体选择性地从 2-氮杂双环 [2.2.1]Hept-5-En-3-One 合成.第三个支架是 4,5-二羟基烟酸,可通过一系列取代基定向的邻位锂化作用获得.选定的化合物作为多种糖苷酶的抑制剂进行了测试.发现三种烟酸衍生物是选择性 β-葡萄糖苷酶抑制剂.(© Wiley-Vch Verlag Gmbh & Co. Kgaa,69451 Weinheim,Germany,2007)
DOI:10.1002/ejoc.200700333

专利信息

专利号:EP-2300484-B1
优先权日:2008-05-05
标题:Novel class of spiro piperidines for the treatment of neurodegenerative diseases
发明人：BRODNEY MICHAEL AARON; HELAL CHRISTOPHER JOHN; O'NEILL BRIAN THOMAS
权利人:PFIZER
摘要:Compounds and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula (I) as defined in the specification. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.

专利号:US-2010152208-A1
优先权日:2007-05-23
标 题:Bicyclic heteroaromatic compounds as inhibitors of stearoyl-coenzyme a delta-9 desaturase
发明人：LEGER SERGE; DESCHENES DENIS; FORTIN REJEAN; ISABEL ELISE; POWELL DAVID
权利人:MERCK FROSST CANADA LTD
摘要:Bicyclic heteroaromatic compounds of structural formula I are inhibitors of stearoyl-coenzyme A delta-9 desaturase (SCD). The compounds of the present invention are useful for the prevention and treatment of conditions related to abnormal lipid synthesis and metabolism, including cardiovascular disease, such as atherosclerosis; obesity; Type 2 diabetes; insulin resistance; hyperglycemia; Metabolic Syndrome; neurological disease; cancer; and liver steatosis. Formula (I).

专利号:US-6017926-A
优先权日:1997-12-17
标题 :Integrin receptor antagonists
发明人：ASKEW BEN C; COLEMAN PAUL J; DUGGAN MARK E; HALCZENKO WASYL; HUTCHINSON JOHN H; MEISSNER ROBERT S; PATANE MICHAEL A; WANG JIABING
权利人:MERCK & CO INC
摘要:The present invention relates to compounds and derivatives thereof, their synthesis, and their use as integrin receptor antagonists. More particularly, the compounds of the present invention are antagonists of the integrin receptors alpha v beta 3, alpha v beta 5 and/or alpha v beta 6 and are useful for inhibiting bone resorption, treating and preventing osteoporosis, and inhibiting vascular restenosis, diabetic retinopathy, macular degeneration, angiogenesis, atherosclerosis, inflammation, wound healing, viral disease, and tumor growth and metastasis.

专利号:US-2012202787-A1
优先权日:2009-10-20
标 题:Novel Heteroaryl Imidazoles And Heteroaryl Triazoles As Gamma-Secretase Modulators
发明人：AM ENDE CHRISTOPHER WILLIAM; JOHNSON DOUGLAS SCOTT; PETTERSSON MARTIN YOUNGJIN; SUBRAMANYAM CHAKRAPANI; O'DONNELL CHRISTOPHER JOHN
权利人:AM ENDE CHRISTOPHER WILLIAM; JOHNSON DOUGLAS SCOTT; PETTERSSON MARTIN YOUNGJIN; SUBRAMANYAM CHAKRAPANI; O'DONNELL CHRISTOPHER JOHN; PFIZER
摘要:Compounds and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula I; n n n n n n n n n n as defined in the specification. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.

专利号:US-8518952-B2
优先权日:2008-08-06
标题 :6 substituted 2-heterocyclylamino pyrazine compounds as CHK-1 inhibitors
发明人：BRAGANZA JOHN FREDERICK; COLLINS MICHAEL RAYMOND; KATH JOHN CHARLES; NINKOVIC SACHA; LI HUI; RICHTER DANIEL TYLER
权利人:BRAGANZA JOHN FREDERICK; COLLINS MICHAEL RAYMOND; KATH JOHN CHARLES; NINKOVIC SACHA; LI HUI; RICHTER DANIEL TYLER; PFIZER
摘要:The present invention is directed to compounds of formula (I), n nand pharmaceutically acceptable salts thereof, their synthesis, and their use as CHK-1 inhibitors.

专利号:US-6268378-B1
优先权日:1997-12-17
标题 :Integrin receptor antagonists
发明人：DUGGAN MARK E; MEISSNER ROBERT S; PERKINS JAMES J
权利人:MERCK & CO INC
摘要:The present invention relates to compounds and derivatives thereof, their synthesis, and their use as vitronectin receptor antagonists. More particularly, the compounds of the present invention are antagonists of the vitronectin receptors alphavbeta3 and/or alphavbeta5 and are useful for inhibiting bone resorption, treating and preventing osteoporosis, and inhibiting vascular restenosis, diabetic retinopathy, macular degeneration, angiogenesis, atherosclerosis, inflammation, viral disease, and tumor growth.