2,7-二羟基萘置于potassium Carbonate,硫酸二甲酯体系中,用 水,丙酮 用作溶剂,化学反应生成2,7-二甲氧基萘 参考文献:Substituted Heterocyclic Compounds,Method For Preparing And Compositions Containing Same 标题:Substituted Heterocyclic Compounds,Method For Preparing And Compositions Containing Same 摘要:该发明涉及以下式(i)的化合物:其中:R1,R2和r3如描述中定义,X如描述中定义,Y代表氧原子,硫原子,C(h)q基团,So或so2,N等于0至5,A代表nr5R6基团,以及含有这些化合物的药物产品,可用于治疗或预防褪黑素失调疾病.
专利号:US-2018312534-A1 优先权日:2015-10-16 标题:Fluorescent anticancer platinum drugs 发明人:SARKAR ARINDAM; MANDAL SWADHIN KUMAR; SENGUPTA ANIRUDDHA; BISWAS GOUTAM; DUTTA PRADIP; SHARMA RUPALI; RAJ JUSTIN PAUL; SURYAVANSHI HEMANT; KUMARI SMITA 权利人:INVICTUS ONCOLOGY PVT LTD 摘要:The present disclosure is in relation to the field of nanotechnology and cancer therapeutics. In particular, the present disclosure relates to fluorescent platinum based compounds. The disclosure further relates to synthesis of said fluorescent platinum based compounds, nanoparticles and compositions comprising said fluorescent platinum based compounds/nanoparticles. The disclosure also relates to methods of managing cancer by the fluorescence changes between aforesaid platinum based compounds and corresponding free ligands, nanoparticles and compositions.
专利号:US-8350064-B2 优先权日:2006-07-21 标题:Fluorescent xanthenes and white light fluorophores 发明人:STRONGIN ROBERT M; WARNER ISIAH M; YANG YOUJUN; LOWRY MARK; FAKAYODE SAYO O; ESCOBEDO CORDOVA JORGE O; XU XIANGYANG 权利人:UNIV LOUISIANA STATE; STRONGIN ROBERT M; WARNER ISIAH M; YANG YOUJUN; LOWRY MARK; FAKAYODE SAYO O; ESCOBEDO CORDOVA JORGE O; XU XIANGYANG 摘要:Xanthene compounds are disclosed having fluorescence at multiple wavelengths. Also disclosed are methods for their synthesis and use. Some of the compounds fluoresce at three wavelengths, emitting white light. Uses include the imaging of biological tissues, illumination, and display technologies. Many of the compounds have large Stokes shifts, and are resistant to photobleaching. The fluorescence may be readily distinguished from that of endogenous fluorophores, and from that of most existing, commercially-available fluorescent probes. The compounds are well suited for use in “multiplexingâ€? techniques. They exhibit clear isosbestic and isoemissive points, and have broad absorption and emission ranges.
专利号:CN-104357045-A 优先权日:2014-11-05 标 题 :Synthesis method and application of spiropyran small-molecule fluorescent probe with extreme acid/extreme base switch response
[参考文献]: C L Perrin, Et Al. Symmetry Of N-H-N Hydrogen Bonds In 1,8-Bis(Dimethylamino)Naphthalene.H+ And 2,7-Dimethoxy-1,8-Bis(Dimethylamino)Naphthalene.H+. J Am Chem Soc. 2001 Jul 11;123(27):6520-6. [参考文献]: Daichi Hijikata, Et Al. 2,7-Dimeth-Oxy-1,8-Bis-(4-Phen-Oxy-Benzo-Yl)Naphthalene. Acta Crystallogr Sect E Struct Rep Online. 2010 Oct 23;66(Pt 11):O2902-3. [参考文献]: Iolinda Aiello, Et Al. Charge-Transfer Matrixes As A Tool To Desorb Intact Labile Molecules By Matrix-Assisted Laser Desorption/ionization. Use Of 2,7-Dimethoxynaphthalene In The Ionization Of Polymetallic Porphyrins. Anal Chem. 2004 Oct 15;76(20):5985-9.
合成参考文献
参考文献:10.1107/s160053681101508x 摘要:Kato Y, Nagasawa A, Sasagawa K, Okamoto A, Yonezawa N. (5-Benzoyl-3,6-dimeth-oxy-naphthalen-2-yl)(phen-yl)methanone. Acta Crystallogr Sect E Struct Rep Online. 2011 May 01;67(Pt 5):o1250. 参考文献:10.1107/s1600536811018332 摘要:Watanabe S, Muto T, Nagasawa A, Okamoto A, Yonezawa N. (2,7-Dimeth-oxy-naphthalen-1-yl)(4-fluoro-phen-yl)methanone. Acta Crystallogr Sect E Struct Rep Online. 2011 Jun 01;67(Pt 6):o1466.