CAS: 3959-05-5; (2-Bromophenyl)Methanamine

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CAS号2042-37-7 邻溴苯腈 | CAS号3433-80-5 邻溴溴苄 | CAS号126799-87-9 1-(azidomethyl)... | CAS号6630-33-7 2-溴苯甲醛 | CAS号18982-54-2 2-溴苄醇 | CAS号34158-72-0 2-溴苯甲醛肟 | CAS号103-81-1 2-苯乙酰胺 | CAS号7726-95-6 溴素 | CAS号54616-47-6 2-溴-N,N-二甲基苯甲酰胺 | CAS号203244-99-9 1-benzyl-3a-met... | CAS号2042-37-7 邻溴苯腈 | CAS号6630-33-7 2-溴苯甲醛 | CAS号2051-97-0 1-苄基吡咯 | CAS号698-19-1 N-甲基-2-溴苄胺 | CAS号608515-49-7 8-溴-3-羟基异喹啉 | CAS号103197-90-6 N-benzyl-2,2-di... | CAS号1125-80-0 3-甲基异喹啉 | CAS号3336-53-6 3-METHYLISOQUIN...

2-溴溴苄置于ammonium Hydroxide体系中,化学反应生成 邻溴苄胺
参考文献:串联s Rn 1取代后的芳基自由基的6-Exo和7-End环化的实验和计算研究
标题:串联s Rn 1取代后的芳基自由基的6-Exo和7-End环化的实验和计算研究
摘要:在亲核试剂me 3 Sn-,Ph 2 P-和o 2 Nch 2-的照射下,在液氨中研究了n-烯丙基-N-(2-卤代苄基)-乙酰胺和衍生物的反应.按照该程序,以高收率获得了新颖的取代的2-乙酰基-1,2,3,4-四氢异喹啉和取代的2-乙酰基-2,3,4,5-四氢-1 H-苯并[C]氮杂.这些反应被认为是通过芳基自由基的中间发生的,而芳基自由基的发生是通过分子内的6-Exo或7-Endo攻击双键环化得到脂族基团,这些脂族基团沿着s Rn 1链环的传播步骤反应,得到环状取代的化合物作为主要产物.使用dft方法对反应进行建模,该方法提供了合理的理解,可以将产物分布与作为中间体的脂肪族自由基的结构及其形成的动力学联系起来.
DOI:10.1021/jo4001788

专利信息

专利号:US-9656927-B2
优先权日:2013-11-01
标题 :Process for the synthesis of carboxylic acid derivatives
发明人：KISHORE PRASAD PRAGATI; SUDALAI ARUMUGAM
权利人:COUNCIL SCIENT IND RES; COUNCIL SCIENT IND RES
摘要:The present invention discloses one-pot synthesis of various carboxylic acid derivatives using copper catalyst and sodium cyanide as the cyanide source for bringing in carbonylative coupling in a single step.

专利号:US-9018371-B2
优先权日:2007-03-07
标 题 :Adenosine derivatives, method for the synthesis thereof, and the pharmaceutical compositions for the prevention and treatment of the inflammatory diseases containing the same as an active ingredient
发明人：JEONG LAK SHIN; KIM HEA OK; JACOBSON KENNETH A; CHOE SEUNG AH
权利人:JEONG LAK SHIN; KIM HEA OK; JACOBSON KENNETH A; CHOE SEUNG AH; FM THERAPEUTICS CO LTD; US OF AMERICA AS REPRESENTED BY THE SECRETARY DEPT OF HEALTH AND HUMAN SERVICES THE OFFICE OF TECHNO
摘要:Disclosed are adenosine derivatives, methods for the synthesis thereof, and pharmaceutical compositions for the prevention and treatment of inflammatory diseases, comprising the same as an active ingredient. The adenosine derivatives have high binding affinity and selectivity for adenosine receptors, especially for A 3 adenosine receptors and act as A 3 adenosine receptor antagonists, and exhibit anti-inflammatory activity. Thus, the adenosine derivatives are useful in the prevention and treatment of inflammatory diseases.

专利号:US-7968752-B2
优先权日:2003-06-16
标 题:Hydrolytically-resistant boron-containing therapeutics and methods of use
发明人：LEE VING; PLATTNER JACOB J; BENKOVIC STEPHEN J; BAKER STEPHEN J; MAPLES KIRK R; BELLINGER-KAWAHARA CAROLYN; AKAMA TSUTOMU; ZHANG YONG-KANG; SINGH RAJESHWAR; SAURO VITTORIO A
权利人:ANACOR PHARMACEUTICALS INC
摘要:Compositions and methods of use of borole derivatives, including benzoxaboroles, benzazaboroles and benzthiaboroles, as therapeutic agents for treatment of diseases caused by bacteria or viruses are disclosed, as well as methods for synthesis of said agents and compositions thereof.

专利号:US-2001024798-A1
优先权日:1998-06-11
标题:Biomimetic combinatorial synthesis
发明人：SHAIR MATTHEW D; LINDSLEY CRAIG W; PELISH HENRY E; SHEEHAN SCOTT M; GOESS BRIAN C; LAYTON MARK E; CHAN LAWRENCE K; CHEN CHUO; WESTWOOD NICHOLAS J
摘要:The present invention provides biomimetic compounds and libraries thereof, as well as methods for their production. In general, the inventive method involves the selection of a desired biological synthetic pathway and mimics that synthetic pathway utilizing modern synthetic tools. The structures formed from this method are preferably generated in fewer than four steps. These scaffold structures can then be functionalized to yield biomimetic compounds and libraries of compounds. In preferred embodiments, biomimetic compounds and libraries are generated from an oxidative phenolic coupling reaction. In other particularly preferred embodiments, the compounds and libraries of compounds are generated from cascade reactions to yield bicyclo [n. 3.1 ] ring systems, medium ring systems, and fused ring systems. In addition to compounds, libraries and methods for their production, the present invention also provides pharmaceutical compositions and methods and kits for determining one or more biological activities of the library members.

专利号:US-4734495-A
优先权日:1985-07-17
标 题 :Process and intermediates for beta-lactam antibiotics
发明人：EVANS DAVID A; SJOGREN ERIC B
权利人:HARVARD COLLEGE
摘要:1-Benzyl(or substituted benzyl)-3β-[4(S)-aryloxazolidin-2-one-3-yl]-4β-(2-arylvinyl)azetidin-2-ones are provided via cycloaddition of a 4(S)-aryloxazolidin-2-one-3-ylacetyl halide and an imine formed with a benzylamine and a 3-arylacrolein, e.g. cinnamaldehyde. The azetidinones are useful chiral intermediates in an asymmetric synthesis of 1-carba(1-dethia)-3-hydroxy-3-cephem-4-carboxylic acids and esters and to monocyclic β-lactam antibiotics.

专利号:CN-1500769-A
优先权日:1996-12-19
标 题 :Process for the solid phase synthesis of aldehydes, ketones, oximes, amines and hydroxamic acid compounds