CAS: 60-24-2; Mercaptoethanol

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CAS号107-07-3 2-氯乙醇 | CAS号243671-61-6 (Z)-2-((2-hydro... | CAS号1892-29-1 2-羟乙基二硫化物 | CAS号29167-28-0 Ethanol,2-[(tri... | CAS号81956-72-1 (carboxymethyl)... | CAS号65-85-0 苯甲酸 | CAS号637-44-5 苯丙炔酸 | CAS号140-10-3 肉桂酸 | CAS号75-21-8 环氧乙烷 | CAS号10603-78-8 2-tributylstann... | CAS号10494-75-4 2-甲氧基乙烷硫醇 | CAS号5271-38-5 2-甲硫基乙醇 | CAS号52772-11-9 硫化水杨酸乙醋 | CAS号1226-99-9 2-(benzoylthio)... | CAS号3878-41-9 2-苄硫基乙醇 | CAS号55764-23-3 2,5-二甲基-3-呋喃硫醇 | CAS号147441-51-8 (2R)-2-(4-bromo... | CAS号1462982-12-2 2,2'-(((4-bromo... | CAS号1462-55-1 硫化2-羟基乙基N-十二基

(Z)-2-((2-Hydroxyethyl)Thio)-1-P-Toluenesulfonylethylene置于四氢吡咯体系中,用 乙腈 作为反应溶剂,以95%的收率获得产物2-巯基乙醇
参考文献:硫醇相对于醇和酚的化学选择性保护.甲苯磺酰基基团
标题:硫醇相对于醇和酚的化学选择性保护.甲苯磺酰基基团
摘要:已经设法将脂族和芳族硫醇共轭加成到乙炔基对甲苯基砜(甲苯磺酰基乙炔)中,以实际上定量的产率化学地(在氧亲核试剂存在下)和立体选择性地(异构体z)提供tosvinyl衍生物.选择的条件是:催化量的et 3 N(仅0.5-1.0 Mol%),反应温度约为0°C,对于酸性较低的硫醇,则为cf 3 CH2Oh或ch 3 Cn / Cf 3 CH2Oh作为反应溶剂.因此,ñ-Boc-Cys-Ome已定量地保护作为其小号在存在-Tosvinyl衍生物ñ-Boc-Ser-Ome和n-Boc-Tyr-Ome.这种新颖的保护基团对几种碱性和酸性条件均稳定.通过在室温下用过量的吡咯烷处理或在0oc下用链烷硫醇根离子处理可将其去除.
DOI:10.1016/s0040-4039(03)01614-9

专利信息

专利号:US-7041479-B2
优先权日:2000-09-06
标题 :Enhanced in vitro synthesis of active proteins containing disulfide bonds
发明人：SWARTZ JAMES ROBERT; KIM DONG-MYUNG
权利人:TRUSTESS OF THE LELAND STANFOR
摘要:Compositions and methods are provided for the enhanced in vitro synthesis of polypeptides containing disulfide bonds. In order to improve the performance of in vitro protein synthesis reactions, pre-treatment and redox buffering of the reaction mix is performed in order to optimize the redox potential. Exogenous enzymes that enhance protein folding and disulfide bond formation may also be added to the reaction.

专利号:US-2025257380-A1
优先权日:2023-01-31
标 题:Method for template-free de novo synthesis of long-chain nucleic acid, and use thereof
发明人：XU CHENG; LIU YUANXIAO
权利人:SHANGHAI TYPING BIOSCIENCE CO LTD
摘要:The present application relates to the fields of molecular biology and biotechnology, and in particular to a method for template-free de novo synthesis of a long-chain nucleic acid, including the following steps: S1, synthesis of double-stranded oligonucleotides; and S2, combination and ligation of the double-stranded oligonucleotides to obtain a target long-chain nucleic acid. The present application achieves continuous synthesis from single nucleotides to long-chain nucleic acids by means of the combination of S1 and S2, and has the advantages of no need for templates, high accuracy, low complexity and low cost.

专利号:US-4013724-A
优先权日:1975-07-24
标题:Synthesis of a dithiol from 1-methyl-2-(2-hydroxyethylthio)-4-[1-methyl-2-(2-hydroxyethylthio)ethyl]cyclohexane
发明人：WARNER PAUL F
权利人:PHILLIPS PETROLEUM CO
摘要:The synthesis of a new diol compound by the reaction of 2-mercaptoethanol and d,1-limonene to produce the diol 1-methyl-2-(2-hydroxyethylthio)-4[1-methyl-2-(2-hydroxyethylthio)ethyl]cyclohexane. The diol can be used as an intermediate in a reaction with a thiourea for the synthesis of a new dithiol, 1-methyl-2-(2-mercaptoethylthio)-4-[1-methyl-2-(2-mercaptoethylthio)-ethyl]cyclohexane.

专利号:US-6548276-B2
优先权日:2000-09-06
标题:Enhanced in vitro synthesis of active proteins containing disulfide bonds
发明人：SWARTZ JAMES ROBERT; KIM DONG-MYUNG
权利人:UNIV LELAND STANFORD JUNIOR
摘要:Compositions and methods are provided for the enhanced in vitro synthesis of polypeptides containing disulfide bonds. In order to improve the performance of in vitro protein synthesis reactions, pre-treatment and redox buffering of the reaction mix is performed in order to optimize the redox potential. Exogenous enzymes that enhance protein folding and disulfide bond formation may also be added to the reaction.

专利号:US-8835477-B2
优先权日:2009-10-06
标题 :Method for the synthesis of 2-thiohistidine and the like
发明人：ERDELMEIER IRÈNE; DAUNAY SYLVAIN
权利人:ERDELMEIER IRÈNE; DAUNAY SYLVAIN; TETRAHEDRON
摘要:Methods for the synthesis of 2-thiohistidine or a derivative thereof of the formula (I), or of a physiologically acceptable salt, a tautomer, a stereoisomer or a mixture of stereoisomers in any proportions thereof, from a compound of the formula (II) or a physiologically acceptable salt, a tautomer, a stereoisomer or a mixture of stereoisomers in any proportions thereof, by cleavage reaction in the presence of a thiol at a temperature higher than or equal to 60° C. The invention also relates to compounds of the formula (II) and a method for the synthesis thereof.

专利号:US-4713479-A
优先权日:1986-11-28
标题 :Synthesis of high-purity dialkyl 2-vinylcyclopropane-1,1-dicarboxylate
发明人：CLARK JR CLARENCE E; FAYTER JR RICHARD G
权利人:NAT DISTILLERS CHEM CORP
摘要:This invention relates to a two-step synthesis of high purity dialkyl 2-vinyl-cyclopropane-1,1-dicarboxylate in which a mixture of trans- and cis-1,4-dihalobutene-2 is first isomerized to essentially trans-1,4-dihalobutene-2 followed immediately by cyclocondensing the resultant trans-1,4-dihalobutene-2 with a malonic ester in the presence of an alcoholic solution of a metallic alkoxide.