CAS: 63358-49-6; (2S,5R,6R)-6-((R)-2-((R)-2-Amino-4-(Methylamino)-4-Oxobutanamido)-2-(4-Hydroxyphenyl)Acetamido)-3,3-Dimethyl-7-Oxo-4-Thia-1-Azabicyclo[3.2.0]Heptane-2-Carboxylic Acid

上下游产品

阿莫西林 Amoxicillin 26787-78-0

(2S,5R,6R)-6-[[(2R)-2-(4-Hydroxyphenyl)-2-[[(2R)-4-(Methylamino)-2-[(2-Nitrophenyl)Sulfinylamino]-4-Oxobutanoyl]Amino]Acetyl]Amino]-3,3-Dimethyl-7-Oxo-4-Thia-1-Azabicyclo[3.2.0]Heptane-2-Carboxylic Acid;Trihydrate 反应生成 阿扑西林
参考文献:Ohshiro,Susumu;Senuma,Masaru;Wagatsuma,Mitsuyoshi
标题:Ohshiro,Susumu;Senuma,Masaru;Wagatsuma,Mitsuyoshi

专利信息

专利号:US-9353057-B2
优先权日:2003-12-30
标 题:Synthesis of acyloxyalkyl carbamate prodrugs and intermediates thereof
发明人：GALLOP MARK A; DAI XUEDONG; SCHEUERMAN RANDALL A; RAILLARD STEPHEN P; MANTHATI SURESH K; YAO FENMEI; PHAN THU; LUDWIKOW MARIA; PENG GE; BHAT SEEMA
权利人:XENOPORT INC
摘要:Methods for synthesis of 1-(acyloxy)-alkyl carbamates, particularly, the synthesis of 1-(acyloxy)-alkyl carbamate prodrugs of primary or secondary amine-containing drugs are described. Also described are methods for synthesis of 1-(acyloxy)-alkyl N-hydroxysuccinimidyl carbonates which are useful intermediates in the synthesis of 1-(acyloxy)-alkyl carbamates are also described.

专利号:US-6015918-A
优先权日:1998-11-10
标 题 :Allyl-derived precursor and synthesis method
发明人：ZHUANG WEI-WEI; NGUYEN TUE; STECKER GREG MICHAEL; EVANS DAVID RUSSELL; HSU SHENG TENG
权利人:SHARP LAB OF AMERICA INC
摘要:A Cu(hfac) allyl-derived ligand precursor has been provided. The ligand includes group consisting of alkyl, phenyl, trialkylsilane, trialkoxylsilane, halodialkylsilane, dihaloalkylsilane, trihalosilane, triphenylsilane, alkoxyl, halogen, chloroformate, cynanide, cycloalkyl, cycloalkylamine, alkyl ether, isocyanate, and pentafluorobenzene. Examples of the allyl-derived ligand precursors have proved to be stable at room temperatures, and sufficiently volatile at higher temperatures. Copper deposited with this precursor has low resistivity and high adhesive characteristics. A synthesis method has been provided which produces a high yield of the above-described precursors, including a Cu(hfac)(allyltrimethylsilane) precursor.

专利号:US-5994571-A
优先权日:1998-11-10
标题 :Substituted ethylene precursor and synthesis method
发明人：ZHUANG WEI-WEI; NGUYEN TUE; CHARNESKI LAWRENCE J; EVANS DAVID RUSSELL; HSU SHENG TENG
权利人:SHARP LAB OF AMERICA INC
摘要:A Cu(hfac) precursor with a substituted ethylene ligand has been provided. The substituted ethylene ligand includes bonds to molecules selected from the group consisting of C 1 to C 8 alkyl, C 1 to C 8 haloalkyl, H, and C 1 to C 8 alkoxyl. One variation, the 2-methyl-1-butene ligand precursor has proved to be stable at room temperature, and extremely volatile at higher temperatures. Copper deposited with this precursor has low resistivity and high adhesive characteristics. Because of the volatility, the deposition rate of copper deposited with this precursor is very high. A synthesis method has been provided which produces a high yield of the above-described precursor.

专利号:US-6669870-B2
优先权日:1998-12-11
标题:Substituted phenylethylene precursor synthesis method
发明人：ZHUANG WEI-WEI; NGUYEN TUE; CHARNESKI LAWRENCE J; EVANS DAVID R; HSU SHENG TENG
权利人:SHARP LAB OF AMERICA INC
摘要:A Cu(hfac) precursor with a substituted phenylethylene ligand has been provided. The substituted phenylethylene ligand includes bonds to molecules selected from the group consisting of C1 to C6 alkyl, C1 to C6 haloalkyl, C1 to C6 phenyl, H and C1 to C6 alkoxyl. One variation, the alpha-methylstyrene ligand precursor has proved to be stable a low temperatures, and sufficiently volatile at higher temperatures. Copper deposited with this precursor has low resistivity and high adhesive characteristics. A synthesis method has been provided which produces a high yield of the above-described precursor.

专利号:US-11873315-B2
优先权日:2017-06-16
标 题 :Chiral n-heterocyclic phosphorodiamidic acids (NHPAS) and derivatives as novel Brønsted acid catalysts
发明人：KANG JUN YONG; HUANG HAI
权利人:The Board of Regents of the Nevada System of Higher Education on Behalf of the Univ of Nevada; THE BOARD OF REGENTS OF THE NEVADA SYSTEM OF HIGHER EDUCATION ON BEHALF OF THE UNIV OF NEVADA LAS VE
摘要:Provided herein are diaryl and arylalkyl phosphonates, useful as intermediates in, for example, the synthesis of leukocyte elastase inhibitors, potassium channel modulators, chemiluminescence materials, and flame retardants, and methods for making same. Also provided are N-heterocyclic phosphorodiamidic acids (NHPAs) useful in reactions such as, for example, in the preparation of diaryl and arylalkyl phosphonates. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

专利号:US-2015158809-A9
优先权日:2013-02-26
标 题 :Method of making 1-(acyloxy)-alkyl carbamate compounds
发明人：WANG HUAN; LIU PENG; DAI QUNYING; YIN HAO; RAILLARD STEPHEN P
权利人:XENOPORT INC
摘要:Methods of preparing carbamate prodrugs of amine-containing drugs are provided. Carbonates useful in the synthesis of the carbamate prodrugs are also provided.