CAS: 71989-23-6; Fmoc-Ile-Oh

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上下游产品

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(2S,3S)-2-(9H-Fluoren-9-Ylmethoxycarbonylamino)-3-Methyl-Pentanoic Acid 2-Trimethylsilanyl-Ethoxymethyl Ester置于magnesium Bromide体系中,用 二氯甲烷 作为反应溶剂,化学反应 2.5H,以83%的收率获得产物fmoc-L-异亮氨酸
参考文献:溴化镁对氨基酸和肽β-(三甲基甲硅烷基)乙氧基甲基(sem)酯的温和选择性裂解
标题:溴化镁对氨基酸和肽β-(三甲基甲硅烷基)乙氧基甲基(sem)酯的温和选择性裂解
摘要:先前已显示溴化镁醚化物可裂解脂肪族酸的β-(三甲基甲硅烷基)乙氧基甲基(sem)酯.在存在于肽化学中通常遇到的保护基的情况下,该方法现已扩展至氨基酸和肽衍生物,包括b°C,Cbz,Fmoc和troc氨基甲酸酯以及苄基,叔丁基和叔丁基二甲基甲硅烷基醚.氟化物敏感的保护基团对溴化镁的稳定性提高了有机合成中sem酯去除的选择性.
DOI:10.1016/s0040-4039(97)00863-0

专利信息

专利号:US-2023391818-A1
优先权日:2020-11-05
标 题:Peptide synthesis method for suppressing defect caused by diketopiperazine formation
发明人：NOMURA KENICHI; KAGE MIRAI; TAMIYA MINORU; KANAZAWA JUNICHIRO
权利人:CHUGAI PHARMACEUTICAL CO LTD
摘要:Solid-phase synthesis of a peptide has a problem that a desired elongation reaction is prevented from proceeding by diketopiperazine and a 6-membered diamine skeleton compound formed when a protective group at the N-terminal is removed. The present inventors have found that when in production of a peptide by a solid-phase method, a peptide in which an amino group at the N-terminal is protected with a protective group having an Fmoc skeleton is treated in a specific solvent with a base having a pKa of 23 or more in acetonitrile as a conjugate acid, and a peptide chain is then elongated, it is possible to solve the problem described above.

专利号:EP-3515880-B1
优先权日:2017-03-17
标题:Methods and compositions for synthesis of encoded libraries
发明人：LI JIN; MORGAN BARRY A; Wan jinqiao; DOU DENGFENG; LIU GUANSAI; CHANG YONG; CHEN QIUXIA; WANG XING; XU YANSHAN; HU DONGYAN; LIU JIAN; CHENG XUEMIN
权利人:HITGEN INC

专利号:CN-115073587-A
优先权日:2022-07-08
标 题 :A kind of synthetic process of semi-continuous liquid phase synthesis of bivalirudin