CAS: 7533-40-6; (S)-2-Amino-4-Methylpentan-1-Ol

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CAS号2666-93-5 methyl L-leucinate | CAS号7517-19-3 L-亮氨酸甲酯盐酸盐 | CAS号61-90-5 L-亮氨酸 | CAS号2743-60-4 L-亮氨酸乙酯 | CAS号2743-40-0 L-亮氨酸乙酯盐酸盐 | CAS号157985-05-2 5-(2-methylprop... | CAS号93-54-9 1-苯基-1-丙醇 | CAS号1334326-62-3 5-isobutyl-3-me... | CAS号82010-31-9 N-B°C-L-亮氨醇 | CAS号28862-79-5 CBZ-D-亮氨酸 | CAS号104-13-2 4-正丁基苯胺 | CAS号85803-45-8 (S)-N-(p-Methox... | CAS号106930-51-2 N-B°C-D-亮氨醇 | CAS号307532-07-6 (S)-2-(二苄基氨基)-4... | CAS号17016-85-2 (S)-4-异丁基噁唑烷-2-酮 | CAS号130748-67-3 N-tosylleucinol

Dl-亮氨酸置于c22H30N6O2(2+)*c20H24O6*2Br(1-),Copper Dichloride体系中,用 乙醇,水 作为反应溶剂,以110 Mg的收率获得产物l-亮氨醇
参考文献:一种用于制备高纯度单构型亮氨醇的手性拆分方法
标题:一种用于制备高纯度单构型亮氨醇的手性拆分方法
摘要:本发明涉及一种用于制备高纯度单构型亮氨醇的手性拆分方法,具体步骤包括:A)以(1R,2R)‑1,2‑环己二胺为前体,经多步衍生制备索烃类手性拆分剂;b)将消旋体亮氨醇溶于乙醇/水混合溶液中,并与单构型亮氨醇等摩尔量的手性拆分剂和氯化铜混合,有固体析出;c)减压旋蒸除去混合溶液中的乙醇,用乙酸乙酯萃取,浓缩滤液,得到光学纯的右旋亮氨醇,其ee值达98.0%以上;d)步骤c中析出固体溶于去离子水,用乙酸乙酯萃取,浓缩滤液,得到光学纯的左旋亮氨醇,其ee值高达99.0%以上.本发明的有益效果是:索烃类手性拆分剂合成方法简单,手性拆分收率高,分离得到的亮氨醇光学纯度高,易于规模化手性拆分.

专利信息

专利号:US-7323575-B2
优先权日:2003-04-09
标题:Process for the synthesis of (2S)-indoline-2-carboxylic acid
发明人：SOUVIE JEAN-CLAUDE; LECOUVE JEAN-PIERRE
权利人:SERVIER LAB
摘要:Process for the synthesis of (2S)-indoline-2-carboxylic acid of formula (I): n nApplication in the synthesis of perindopril and its pharmaceutically acceptable salts.

专利号:US-10040752-B2
优先权日:2015-08-24
标 题 :Synthesis of levomethadone hydrochloride or dextromethadone hydrochloride and methods for use thereof
发明人：MKRTCHYAN GNEL; YAO QINGWEI
权利人:CODY LABORATORIES INC
摘要:Highly efficient methods for synthesis of levomethadone hydrochloride or dextromethadone hydrochloride are provided starting from D-alanine, or L-alanine, respectively, with retention of configuration. Methods for treating a subject are provided comprising administering a composition comprising an effective amount of levomethadone hydrochloride having not more than 10 ppm dextromethadone.

专利号:US-9206222-B2
优先权日:2009-06-29
标题:Solid phase peptide synthesis of peptide alcohols
发明人：CAUSSIL-AMBLARD MURIEL; MARTINEZ JEAN; TAILHADES JULIEN
权利人:CAUSSIL-AMBLARD MURIEL; MARTINEZ JEAN; TAILHADES JULIEN; CENTRE NAT RECH SCIENT
摘要:The present invention relates to the synthesis of depsipeptides on solid phase support. Said depsipeptides are then implicated in a solution phase O—N acyl shift enabling to obtain the corresponding peptide alcohols.

专利号:US-6423871-B1
优先权日:1999-02-26
标题 :Efficient synthesis of secondary amines by selective alkylation of primary amines
发明人：JUNG KYUNG WOON
权利人:UNIV SOUTH FLORIDA
摘要:A method for selective mono-N-alkylation of primary amines to produce secondary amines that are substantially free of overalkylated tertiary amines and quaternary ammonium salts, under mild reaction conditions without the necessity of protecting groups. Compounds of the class of secondary amines are produced by reacting an alkyl halide with an alkyl amine in anhydrous solvent, preferably dimethyl sulfoxide or N,N-dimethylformamide, in the presence of 0.1 to 3 molar equivalents of a cesium base. Optionally, the extent and selectivity of mono-N-alkylation is enhanced by addition to the reaction mixture of a powdered molecular sieve material for removal of water produced by the reaction, and/or tetrabutylammonium iodide to promote halide exchange. The invention permits selective and efficient mono-N-alkylation of a wide variety of substrates at 23° C.; does not cause racemization when used with enantiomerically-pure chiral substrates such as L-α-aminoesters; and is applied to solid phase synthesis whereby either the alkyl amine or alkyl halide is immobilized. The method is additionally used to produce polyamines, such as N-(2-(2-aminoethylthio)ethyl)ethylenediamine in 73% yield.

专利号:WO-0050377-A1
优先权日:1999-02-26
标 题:Efficient synthesis of secondary amines by selective alkylation of primary amines
发明人：JUNG KYUNG WOON
权利人:UNIV SOUTH FLORIDA
摘要:A method for selective mono-N-alkylation of primary amines to produce secondary amines that are substantially free of overalkylated tertiary amines and quaternary ammonium salts, under mild reaction conditions without the necessity of protecting groups. Compounds of the class of secondary amines are produced by reacting an alkyl halide with an alkyl amine in anhydrous solvent, preferably dimethyl sulfoxide or N,N-dimethylformamide, in the presence of 0.1 to 3 molar equivalents of a cesium base. Optionally, the extent and selectivity of mono-N-alkylation is enhanced by addition to the reaction mixture of a powdered molecular sieve material for removal of water produced by the reaction, and/or tetrabutylammonium iodide to promote halide exchange. The invention permits selective and efficient mono-N-alkylation of a wide variety of substrates at 23 °C; does not cause racemization when used with enantiomerically-pure chiral substrates such as L-α-aminoesters; and is applied to solid phase synthesis whereby either the alkyl amine or alkyl halide is immobilized. The method is additionally used to produce polyamines, such as N-(2-(2-aminoethylthio)ethyl)ethylenediamine in 73 % yield.

专利号:US-2001047100-A1
优先权日:2000-04-26
标 题:Chiral imidazoyl intermediates for the synthesis of 2-(4-imidazoyl)-cyclopropyl derivatives
发明人：KJAERSGAARD HANS JOERGEN; PHILLIPS JIM; ALI SYED M
摘要:Novel intermediates useful in the preparation of optically active H 3 histamine receptor antagonist 2-(4-imidazoyl)-cyclopropyl derivatives are disclosed.