CAS: 14813-01-5; 1-Benzylpiperidin-3-Ol

相似化合物

105973-51-1 91599-81-4 143900-43-0

上下游产品

CAS号40114-49-6 1-苄基-3-哌啶酮 | CAS号64051-79-2 3-羟基哌啶盐酸盐 | CAS号100-44-7 氯化苄 | CAS号6859-99-0 3-羟基哌啶 | CAS号100-39-0 溴化苄 | CAS号100-52-7 苯甲醛 | CAS号62214-78-2 1-benzyl-3-hydr... | CAS号50606-58-1 1-苄基-3-哌啶酮盐酸盐 | CAS号3323-73-7 1-苄基-3-羟基吡啶-1-鎓氯化物 | CAS号109-00-2 3-羟基吡啶 | CAS号40114-49-6 1-苄基-3-哌啶酮 | CAS号91599-81-4 (R)-(-)-1-苄基-3-羟基哌啶 | CAS号91599-74-5 盐酸贝尼地平 | CAS号6859-99-0 3-羟基哌啶 | CAS号85387-34-4 1-苄基哌啶-3-基3-氧代丁酸酯 | CAS号57734-44-8 (1-苄基吡咯烷-2-基)甲胺

3-羟基吡啶置于甲醇,Sodium Tetrahydroborate体系中,用 甲醇 用作溶剂,化学反应 7.0H,反应生成1-苄基-3-哌啶醇
参考文献:一种盐酸贝尼地平中间体的合成方法
标题:一种盐酸贝尼地平中间体的合成方法
摘要:本发明公开了一种盐酸贝尼地平中间体的合成方法,它是以3‑羟基吡啶和卤化苄在溶剂回流的条件下发生亲核取代反应,生成1‑苄基‑3‑羟基吡啶嗡卤化物;以醇用作溶剂将其还原成1‑苄基‑3‑哌啶醇;然后1‑苄基‑3‑哌啶醇与乙酰乙酸乙酯以甲苯用作溶剂,在有催化剂或无催化剂的存在下,回流发生酯交换反应生成乙酰乙酸(1‑苄基‑3‑哌啶基)酯,且在醇剩下少于30%的情况下,常压蒸馏,直至醇反应完全得到产品,本发明简单,三步总收率可达到80%以上,且所用物料都是工业化产品,价廉,易得,质量容易控制.

专利信息

专利号:US-6566525-B1
优先权日:1998-09-17
标 题:Preparation of N-substituted-hydroxycycloalkylamine derivatives
发明人：KIM SEONG JIN; KIM KEON IL; YANG KYOUNG YOUL
权利人:SAMSUNG FINE CHEMICALS CO LTD
摘要:A process for the preparation of N-substituted-hydroxycycloalkylamine derivatives, that are useful intermediates for the synthesis of various organic chemicals including pharmaceutical and agrochemical compounds, represented by formula (1), by reacting a 1,2-dihydroxalkyl alcohol, represented by the following formula (2), with a thionyl halide to produce an intermediate 1,2-cyclosulfinylalkyl halide represented by the following formula (3); and then cyclizing that intermediate with an amine compounds represented by the following formula (4).In the above structural formuli, * represents an asymmetric carbon atom; R1 is hydrogen or an amino-protecting group; m is an integer of 1-3; and X is halogen. The reactant compounds as well as the compounds made according to this invention have the following substitution pattern:n=1, R2=OH, R3=H and m=1; n=1, R2=H, R3=CH2OH and m=2;n=2, R2=OH, R3=H; and m=2; and n=2, R2=H, R3=CH2OH and m=3.

专利号:CN-119977863-A
优先权日:2024-12-31
标题:Synthesis process of (((2S) -4- (-) -3-hydroxy-4-oxo-1- ((S) -2- (-) -butan-2-yl) carbamic acid tert-butyl ester

专利号:CN-111848495-B
优先权日:2020-06-02
标 题 :Synthesis method of 1-benzyl-3-piperidinol

专利号:CN-101817779-B
优先权日:2010-05-19
标 题 :Synthesis process, nickel-based catalyst and preparation method of N-benzyl-3-piperidinol

专利号:CN-101817779-A
优先权日:2010-05-19
标 题 :Novel synthesis process of N-benzyl-3-piperidinol, novel nickel-based catalyst and preparation method thereof