CAS: 224311-49-3; 2'-(Di-Tert-Butylphosphino)-N,N-Dimethyl-[1,1'-Biphenyl]-2-Amine

上下游产品

di(tert-butyl)chlorophosphine 2'-bromo-N,N-dimethyl-[1,1'-biphenyl]-2-amine 2-bromo-1-chlorobenzene 1-chloro-2-(dimethylamino)benzene bis(3-phenyl-1H-inden-7-yl) ether 1-methoxy-N,1-diphenyl-4-indanamine

二叔丁基氯化膦,2-(二甲氨基)-2'-溴-1,1'-联苯置于正丁基锂体系中,化学反应生成2-二叔丁基磷-2-(N,N-二甲氨基)联苯
参考文献:新型富电子大膦配体促进钯催化制备二芳基醚
标题:新型富电子大膦配体促进钯催化制备二芳基醚
摘要:描述了钯催化形成二芳基醚的一般方法.富含电子的,庞大的芳基二烷基膦配体,其中两个烷基是叔丁基或 1-金刚烷基,是转化成功的关键.使用氢化钠或磷酸钾作为碱,在 100 oc 的甲苯中,可以将各种缺电子,电子中性和富电子的芳基溴化物,氯化物和三氟甲磺酸酯与各种酚结合.膦配体庞大而碱性的性质被认为是提高二芳基醚从钯中还原消除的速率的原因.
Doi:10.1021/ja990324R

专利信息

专利号:US-11180508-B2
优先权日:2017-12-05
标 题:Chemical process for the synthesis of herbicidal pyrazolidinedione compounds
发明人：MORRIS JAMES ALAN; SHAFIR ALEXANDR; GONU MALLIKHARJUNA; BILAL IFFAT; SALE DAVID ALEXANDER
权利人:SYNGENTA PARTICIPATIONS AG
摘要:The present invention relates to a novel process for the synthesis of herbicidal pyrazolidinedione compounds. In particular, a process for the preparation of a compound of formula (I), wherein R1, R2 and R3 are as defined herein. The present invention further relates to novel intermediate compounds utilized in said process, and methods for preparing said intermediate compounds.

专利号:US-2024336649-A1
优先权日:2021-06-21
标 题 :Synthesis of covalent protein dimers that can inhibit myc-driven transcription
发明人：LOAS ANDREI; PENTELUTE BRADLEY L; POMPLUN SEBASTIAN; JBARA MUHAMMAD; SCHISSEL CARLY KATHERINE; RODRIQUEZ JACOB JOSHUA LEE; BUCHWALD STEPHEN LEFFLER; BOIJA ANN; KLEIN ISAAC; HAWKEN SUSANA WILSON; LI CHARLES HAN
权利人:MASSACHUSETTS INST TECHNOLOGY; WHITEHEAD INSTITUTE OF BIOMEDICAL RES
摘要:The disclosure relates to covalent protein dimers of MYC, MAX, and Omomyc; pharmaceutical compositions comprising the covalent protein dimers; methods of making the covalent protein dimers; and methods of treating disorders associated with MYC dysregulation (e.g., cancer) with the covalent protein dimers.

专利号:US-11718584-B2
优先权日:2019-02-22
标题 :Process for the synthesis anthranilic diamide compounds and intermediates thereof
发明人：KARRI PHANEENDRASAI; PABBA JAGADISH; SHINDE BHARAT UTTAMRAO; KALWAGHE AMOL DNYANESHWAR; MADHAVRAO KAMBLE MARUTI; KLAUSENER ALEXANDER G M; PANMAND DEEPAK SHANKAR
权利人:PI INDUSTRIES LTD
摘要:The present invention disclosed a process for the synthesis of anthranilic diamide compound of formula (I), n n n n n n n n n n wherein, R 1 , R 2 , R 3a , R 3b , R 3c , R 4 , R 5 , R 6 and Z are as defined in the detailed description. The process comprising the step of obtaining a mono- or dicyano substituted aniline compound of formula (IV) which is then converted to an anthranilic acid compound of formula (V) or an anthranilic amide compound of formula (Va). Further, the compound of formula (VI) can be optionally synthesized from compound of formula (IV or V or Va)

专利号:US-2023150994-A1
优先权日:2020-04-07
标 题:Methods for synthesis of chk1 inhibitors
发明人：SCHWAEBE MICHAEL; ROSNER THORSTEN; ZHAO DALIAN; MILLER ROSS; DULINA RICH; HUMORA MICHAEL; GOTTSCHLING STEPHEN E
权利人:SIERRA ONCOLOGY INC
摘要:The present technology relates to processes, compounds, compositions, and methods useful for coupling reactions. Also, the present disclosure provides for novel intermediates, compositions of matter, and processes relating to the Chk1 inhibitor, SRA737.

专利号:US-2025313551-A1
优先权日:2022-12-15
标题 :Process for the preparation of a quinazolinone derivative
发明人：DOTT PASCAL JEAN CLAUDE; FANTASIA SERENA MARIA; GUILLEMOT-PLASS MAUD; KALDRE DAINIS; LARI GIACOMO MARCO; MODOLO-CHELLAT ISABELLE GEORGETTE HUGUETTE; SEDELMEIER JOERG MATHIAS; TROKOWSKI SEBASTIAN
权利人:HOFFMANN LA ROCHE
摘要:The present invention relates to a new process for the preparation of (3R)—N-[2-cyano-4-fluoro-3-(3-methyl-4-oxo-quinazolin-6-yl)oxy-phenyl]-3-fluoro-pyrrolidine-1-sulfonamide, as well as to a novel intermediate useful for the synthesis of said compound at large scale.

专利号:US-9718807-B2
优先权日:2012-06-05
标 题 :Synthesis of antiviral compound
发明人：SCOTT ROBERT WILLIAM; VITALE JUSTIN PHILIP; MATTHEWS KENNETH STANLEY; TERESK MARTIN GERALD; FORMELLA ALEXANDRA; EVANS JARED WAYNE
权利人:GILEAD PHARMASSET LLC
摘要:The present disclosure provides processes for the preparation of a compound of formula I: n nwhich is useful as an antiviral agent. The disclosure also provides compounds that are synthetic intermediates to compounds of formula I.