CAS: 3215-64-3; 2-(2,6-Dichlorophenyl)Acetonitrile

上下游产品

2-(2,6-二氯苯基)硫代乙酰胺 2-(2,6-Dichlorophenyl)Ethanethioamide 17518-49-9

1,3-Dichloro-2-(2,2-Difluorovinyl)Benzene置于ammonium Hydroxide体系中,用 乙腈 用作溶剂,化学反应 24.0H,以72%的收率获得2,6-二氯苯乙腈
参考文献:从 Gem-二氟烯烃中快速简单地获得 α-(杂)芳基乙腈
标题:从 Gem-二氟烯烃中快速简单地获得 α-(杂)芳基乙腈
摘要:开发了一种可扩展的偕二氟烯烃氰化为(杂)芳基乙腈衍生物的方法.该策略具有反应条件温和,产率高,底物范围广,官能团耐受性广等特点.值得注意的是,在该反应中,氨水为"cn"试剂提供了"n"源,并且完全避免使用有毒的氰化试剂或金属催化剂.因此,我们为芳基乙腈的合成提供了一种绿色替代方法.
Doi:10.1021/acs.Orglett.1C04336

专利信息

专利号:US-4460604-A
优先权日:1976-06-03
标 题 :4-Amino-4-aryl-cyclohexanones
发明人：LEDNICER DANIEL
权利人:UPJOHN CO
摘要:A class of 4-amine-4-arylcyclohexanones, their ketals, and acid addition salts have been synthesized and found to be useful for relieving pain in animals. Their analgesic activity appears to be of high order, and in addition some exhibit narcotic antagonist activity that is useful in modifying the cardiovascular, respiratory, and behavioral depression caused by other analgesics. Several show mixed analgesic and narcotic antagonist activity. Preferred compounds of the class are 4-(m-hydroxyphenyl)-4-dimethylaminocyclohexanone ethylene ketal, and 4-(m-hydroxyphenyl)-4-(n-butylmethylamino)cyclohexanone ethylene ketal as free bases and as their hydrochloride salts. Processes for synthesis and intermediates are described. Unit dosage forms and therapeutic treatments are disclosed.

专利号:IL-180256-A
优先权日:2004-07-15
标题 :Pyrido [d – 2,3] pyrimidinyl-amine history, intermediates for synthesis, process for preparation of compounds, drug, pharmaceutical preparation, and use of history for drug preparation