CAS: 446-52-6; 2-Fluorobenzaldehyde

上下游产品

CAS号446-51-5 2-氟苄醇 | CAS号394-47-8 2-氟苯甲腈 | CAS号393-52-2 邻氟苯甲酰氯 | CAS号462-06-6 氟苯 | CAS号68-12-2 N,N-二甲基甲酰胺 | CAS号10345-76-3 N,N-二乙基 2-氟苯甲酰胺 | CAS号445-29-4 邻氟苯甲酸 | CAS号95-52-3 邻氟甲苯 | CAS号552-89-6 邻硝基苯甲醛 | CAS号112253-19-7 2-[4-(2-formylp... | CAS号348-32-3 4-氟吲哚-2-羧酸乙酯 | CAS号49590-51-4 双(2-甲酰苯基)醚 | CAS号58028-74-3 2-(1-吡咯烷基)苯甲醛 | CAS号342-24-5 2-氟二苯甲酮 | CAS号394-47-8 2-氟苯甲腈 | CAS号445-28-3 2-氟苯甲酰胺 | CAS号50777-76-9 2-二苯基膦苯甲醛 | CAS号399-68-8 4-氟吲哚-2-羧酸 | CAS号389-31-1 2-氟-DL-扁桃酸

2-氟苯腈置于ni/al-Alloy 甲酸,氢气体系中,用 水 作为反应溶剂,70.0 °C,1.8 Mpa 条件下,反应 10.0H,以80%的收率获得产物2-氟苯甲醛
参考文献:Katalytische Reduktion Von Benzonitrilderivaten Zu Benzaldehydderivaten
标题:Katalytische Reduktion Von Benzonitrilderivaten Zu Benzaldehydderivaten
摘要:这项发明涉及一种在水酸存在下,利用镍和铝催化剂以及氢气将取代苯甲腈还原为取代苯甲醛的方法.

专利信息

专利号:US-5861532-A
优先权日:1997-03-04
标 题:Solid-phase synthesis of N-alkyl amides
发明人：BROWN EDWARD G; NUSS JOHN M
权利人:CHIRON CORP
摘要:Methods for solid phase synthesis of N-alkyl amides comprise reductive amination of carbonyl compounds using a reducing agent and an amine-containing linker bound to a solid support. The methods afford high yields of linker-bound, monoalkylated amines, and subsequent coupling with acid derivatives provide derivatized N-substituted amides in excellent yields after cleavage from the solid-phase. Compositions useful in solid phase synthesis are also described.

专利号:US-8415510-B2
优先权日:2008-02-28
标题 :Synthesis of a PEG-6 moiety from commercial low-cost chemicals
发明人：ENGELL TORGRIM
权利人:ENGELL TORGRIM; GE HEALTHCARE LTD
摘要:The present invention provides novel synthesis's for obtaining a protecting group aminoxy PEG-6 linker from cost effective, and readily available starting materials and chemicals or modified polyethylene glycols. More specifically, a novel synthesis of obtaining a modified Boc-protected aminoxy PEG-6 linker was achieved so that said linker may be attached to a vector such as a peptide based fragment.

专利号:US-10730904-B2
优先权日:2012-11-14
标 题:Method for liquid-phase synthesis of nucleic acid
发明人：NONOGAWA MITSURU; NAGATA TOSHIAKI; SAITO HIDEKI; YASUMA TSUNEO
权利人:TAKEDA PHARMACEUTICALS CO
摘要:In this method, an oligonucleotide represented by formula (II) [wherein Y 1 , Q, Base, r and r′ are each as defined in claim 1 ] is prepared by using, as a synthesis unit, a novel nucleoside monomer compound represented by formula (I) [wherein X, R 1 , Y, Base, Z, Ar, R 2 , R 3 and n are each as defined in claim 1 ]. The novel nucleoside monomer compound is a nucleoside, the base moiety of which is substituted with an aromatic-hydrocarbon-ring-carbonyl or -thiocarbonyl group having at least one hydrophobic group. The method can dispense with column-chromatographic purification in every reaction, and enables base elongation not only in the 3′-direction but also in the 5′-direction, thus attaining efficient liquid-phase mass synthesis of an oligonucleotide.

专利号:US-10266565-B2
优先权日:2011-04-12
标 题 :Peptide mimetic ligands of polo-like kinase 1 polo box domain and methods of use
发明人：BURKE JR TERRENCE R; LIU FA; LEE KYUNG S; PARK JUNG-EUN
权利人:BURKE JR TERRENCE R; LIU FA; LEE KYUNG S; PARK JUNG EUN; THE US SECRETARY DEPARTMENT OF HEALTH & HUMAN SERVICES
摘要:Novel compounds are provided that bind to polo-like kinases through the polo-box domain. In certain embodiments, the novel compounds are PEGylated peptides. The PEGylated peptides in accordance with the invention demonstrate high PBD-binding affinity. In certain embodiments, the PEGylated peptides have also achieved activities in whole cell systems. The invention also provides compounds that bind polo-like kinases through the polo-box domain and possess reduced anionic charge. Further provided are methods of design and/or synthesis of the PEGylated peptides and methods of use thereof. The invention provides methods of use of the compounds and methods of synthesis of the compounds.

专利号:US-5679864-A
优先权日:1995-11-03
标题:Process for the synthesis of curcumin-related compounds
发明人：KRACKOV MARK HARRY; BELLIS HAROLD EDWARD
权利人:GENE PRINT INC
摘要:The invention is directed to a process for the synthesis of curcumin and curcumin-related compounds by reacting the enol form of a 2,4-diketone with a monocarbocyclic aldehyde in the presence of an organic amine catalyst. The reactants are dissolved in a highly polar, aprotic organic solvent. The curcumin-related product is recovered in crystalline form by precipitation from the reaction mass and solvent recrystallization.

专利号:WO-2025132776-A1
优先权日:2023-12-20
标题 :Use of iron-based compounds for the synthesis of borated compounds, and corresponding methods
发明人：HANNEDOUCHE JÉRÔME; BEZZENINE SOPHIE; GIL RICHARD; CHEN DONGHUANG; WOWK VINCENT
权利人:UNIV PARIS SACLAY; CENTRE NAT RECH SCIENT
摘要:The present invention relates to the use of iron-based compounds for the synthesis of borated compounds, and the corresponding methods.