CAS: 4803-74-1; 5,6-Dimethoxy-2-(Pyridin-4-Ylmethylene)-2,3-Dihydro-1H-Inden-1-One

相似化合物

4803-74-1 1188913-39-4 24760-34-7

上下游产品

CAS号872-85-5 4-吡啶甲醛 | CAS号2107-69-9 5,6-二甲氧基-1-茚酮 | CAS号2747-08-2 2-溴-5,6-二甲氧基-1-茚酮 | CAS号4803-57-0 5,6-二甲氧基-2-(4-吡...

专利信息

专利号:US-2014128613-A1
优先权日:2011-03-25
标 题:A process for preparation of intermediates of donepezil hydrochloride
发明人：GURUSAMY RENUGADEVI; ROY MITA; SHANMUGANATHAN RAMASUBRAMANIAN; JAGTAP ASHUTOSH; HARIHARAN SIVARAMAKRISHNAN; MISHRA SUSHIL KUMAR; WANKHEDE KARUNA
权利人:GURUSAMY RENUGADEVI; ROY MITA; SHANMUGANATHAN RAMASUBRAMANIAN; JAGTAP ASHUTOSH; HARIHARAN SIVARAMAKRISHNAN; MISHRA SUSHIL KUMAR; WANKHEDE KARUNA; PIRAMAL ENTPR LTD
摘要:The present invention provides a process for the preparation of key intermediate for the synthesis 5,6-dimethoxy-2-[[1-(phenylmethyl)-4-piperidinyl]methyl]-1-indanone hydrochloride (donepezil hydrochloride). The present invention particularly provides a process for the preparation of 5,6-dimethoxy-2-(4-pyridylmethylene)-1-indanone comprising condensation of 5,6-dimethoxy-1-indanone with 4-pyridinecarboxaldehyde using an alkali metal hydroxide as a mild base in the presence of demineralized water as a solvent at a temperature in the range of 15° C. to 45° C. to yield 5,6-dimethoxy-2-(4-pyridylmethylene)-1-indanone, which is subsequently benzylated using benzyl bromide in the presence of solvent at a reflux temperature to yield 1-benzyl-4-[(5,6-dimethoxy-1-indanone-2-yl)methylene]pyridinium bromide.