CAS: 5911-08-0; (Chloromethyl)Cyclopropane

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CAS号2516-33-8 环丙基甲醇 | CAS号56-23-5 四氯化碳 | CAS号112057-32-6 cyclopropylmeth... | CAS号594-11-6 methylcyclopropane | CAS号122651-94-9 3-cyclopropylme... | CAS号75637-38-6 cyclopropylcarb... | CAS号364612-99-7 cyclobutoxychlo... | CAS号310447-99-5 3,4-dichlorobut... | CAS号2919-23-5 环丁醇 | CAS号5162-44-7 4-溴-1-丁烯 | CAS号4399-47-7 溴化环丁烷 | CAS号7051-34-5 溴甲基环丙烷 | CAS号33574-02-6 (碘甲基)环丙烷 | CAS号927-73-1 4-氯-1-丁烯 | CAS号1120-57-6 环丁基氯 | CAS号36982-54-4 acetic acid,cyc... | CAS号57297-73-1 cyclobutyl acetate | CAS号2516-33-8 环丙基甲醇

甲基环丙烷置于氯体系中,化学反应生成 环丙基甲基氯
参考文献:小环化合物.四,环丁基,环丙基羰基和烯丙基羰基衍生物的互变反应
标题:小环化合物.四,环丁基,环丙基羰基和烯丙基羰基衍生物的互变反应
摘要:研发了许多导致环丁基,环丙基羰基和烯丙基羰基衍生物相互转化的反应.在以下方面观测到一定程度的相互转化:甲基环丙烷的气相光催化氯化;环丙甲醇与亚硫酰氯,卢卡斯试剂,三溴化磷和氢溴酸反应;用亚硫酰氯裂解环丙基羰基三乙基甲硅烷基醚;环丁醇与亚硫酰氯和卢卡斯试剂反应;环丙基羰基-,环丁基-和烯丙基羰基胺与亚硝酸的反应;环丙基羰基和环丁基氯化物的水解和乙酰化;n-环丙基羰基-和n-环丁基苯甲酰胺与五溴化磷的反应;环丙基羰基卤化物的格氏反应.在以下情况中没有观测到相互转化:烯丙基甲醇与亚硫酰氯和三溴化磷的反应;环丁烷的气相光催化氯化;烯丙基羰基和环丁基卤化物的格氏反应.考虑到碳正离子的稳定性和互变的难易程度,以及所涉及反应的可逆程度和可能产物的稳定性,已将那些可以合理预期涉及碳正离子中间体的互变反应的产物相关联.环丙基羰基卤化物已被证明在溶剂分解反应中具有异常的反应性,事实上,比类似构成的烯丙基卤
DOI:10.1021/ja01150A029

专利信息

专利号:US-5468876-A
优先权日:1986-05-22
标题:Intermediates for the stereoconservative synthesis of 1-substituted (S)-and (R)-2-aminomethylpyrrolidines
发明人：FEDERSEL HANS-JUEGEN; HOE THOMAS; RAEMSBY STEN I; STROEM PETER H E
权利人:ASTRA AB
摘要:Disclosed are (R)- and (S)-isomers of the compounds of the Formulas II and III with at least 95% optical purity ##STR1## wherein R 1 and R 2 are the same or different and represent a hydrogen atom, a lower alkyl, lower alkenyl or lower alkynyl group, a cycloalkyl group or a group (CH 2 ) m Ph, wherein m is 0-3 and Ph is a substituted or unsubstituted phenyl group. n These compounds are intermediates in the stereoconservative synthesis of 1-substituted (S)- and (R)-2-aminomethylpyrrolidines.

专利号:US-6013796-A
优先权日:1996-07-26
标 题:Preparation of naltrexone from codeine and 3-benzylmorphine
发明人：HUANG BAO-SHAN; LU YANSONG; JI BEN-YI; CHRISTODOULOU ARIS P
权利人:PENICK CORP
摘要:For the synthesis of 3-methylnaltrexone from codeine in this invention, codeine is converted to 6-acetylcodeine, which is N-demethylated to 6-acetylcodeine hydrochloride, followed by alkylating the nitrogen to form 17-cyclopropylmethylnorcodeine. The latter is oxidized to 17-cyclopropylmethylnorcodeinone. For the synthesis of naltrexone from morphine in this invention, morphine is converted to 3-benzylnormorphine as described above in the synthesis of noroxymorphone. 3-Benzylnormorphine is reacted with cyclopropylmethyl halide to produce 3-benzyl-17cyclopropylmethylnormorphine, a novel compound, which is oxidized to 3-benzyl-17-cyclopropylmethyl-normorphinone, a novel compound, by Swern oxidation.

专利号:US-8853401-B2
优先权日:2009-04-24
标 题 :Processes for the preparation of morphinane and morphinone compounds
发明人：HUDLICKY TOMAS; CARROLL ROBERT; LEISCH HANNES; MACHARA ALES; WERNER LUKAS; ADAMS DAVID R
权利人:HUDLICKY TOMAS; CARROLL ROBERT; LEISCH HANNES; MACHARA ALES; WERNER LUKAS; ADAMS DAVID R; UNIV BROCK
摘要:The present application describes processes for the synthesis of morphinane and morphinone compounds, useful as pharmaceutical agents. Also included are novel intermediates useful in the preparation of these compounds. The process comprises quaternization of oripavine to provide a mixture of the R- and S-isomeric (at the nitrogen) quaternary salts. The R-isomer is readily isolated and converted to various N-(R)-morphinane and N-(S)-morphinone compounds. The R-isomer, S-isomer or a mixture of R- and S-isomers may be demethylated and converted to various morphinane and morphinone compounds.

专利号:US-6531470-B1
优先权日:1998-01-23
标题:Oxazolidinone combinatorial libraries, compositions and methods of preparation
发明人：GORDEEV MIKHAIL F; LUEHR GARY W; PATEL DINESH V; NI ZHI-JIE; GORDON ERIC
权利人:UPJOHN CO
摘要:Oxazolidinones and methods for their synthesis are provided. Also provided are combinatorial libraries comprising oxazolidinones, and methods to prepare the libraries. Further provided are methods of making biologically active oxazolidinones as well as pharmaceutically acceptable compositions comprising the oxazolidinones. The methods of library preparation include the attachment of oxazolidinones to a solid support. The methods of compound preparation in one embodiment involve the reaction of an iminophosphorane with a carbonyl containing polymeric support.

专利号:EP-4613751-A1
优先权日:2024-03-07
标 题 :Method of making chemical compounds useful for the synthesis of buprenorphine

专利号:WO-8707271-A1
优先权日:1986-05-22
标 题 :A stereoconservative synthesis of 1-substituted (s)- and (r)-2-aminomethylpyrrolidines and intermediates thereto