CAS: 63980-70-1; 1-(3-Chloro-2-Methylphenyl)Thiourea

上下游产品

CAS号87-60-5 3-氯-2-甲基苯胺 | CAS号19241-35-1 3-氯-2-甲基苯基异硫氰酸酯 | CAS号6259-40-1 3-氯-2-甲基苯胺盐酸盐 | CAS号65373-18-4 2-氨基-5-氯-4-甲基苯并噻唑

2-氨基-6-氯甲苯盐酸盐置于氨,碳酸氢钠体系中,用 甲醇,氯仿 作为反应溶剂,化学反应 12.5H,反应生成 1-(3-氯-2-甲基苯基)-2-硫脲
参考文献:Synthesis Of Thiophene-2-Carboxamidines Containing 2-Amino-Thiazoles And Their Biological Evaluation As Urokinase Inhibitors
标题:Synthesis Of Thiophene-2-Carboxamidines Containing 2-Amino-Thiazoles And Their Biological Evaluation As Urokinase Inhibitors
摘要:The Serine Protease Urokinase (Upa) Has Been Implicated In The Progression Of Both Breast And Prostate Cancer. Utilizing Structure Based Design,The Synthesis Of A Series Of Substituted 4-[2-Amino-1,3-Thiazolyl]-Thiophene-2-Carboxamidine Is Described. Further Optimization Of This Series By Substitution Of The Terminal Amine Yielded Urokinase Inhibitors With Excellent Activities. (C) 2001 Elsevier Science Ltd. All Rights Reserved.
DOI:10.1016/s0960-894X(01)00102-0

专利信息

专利号:CN-104059060-A
优先权日:2014-05-30
标题 :A kind of 5-(1H-indole-3-methylene)-1,3-thiazolidin-4-one derivatives and its synthesis method and application