CAS: 86-51-1; 2,3-Dimethoxybenzaldehyde

该化合物是一种多用途芳香甲醚,有两种甲氧替代物.它具有极佳的稳定性和高纯度,因此适合有机合成.它有助于各种反应,包括核生殖添加和环闭反应,因为其反应性芳香系统.它的确切结构和纯度确保了研究和工业应用的可靠性能.

英文名称2,3-Dimethoxybenzaldehyde
中文名称2,3-二甲氧基苯甲醛
IUPAC名称2,3-dimethoxybenzaldehyde
其它别名o-Veratraldehyde(6CI,7CI,8CI); Benzaldehyde,2,3-dimethoxy-; 5,6-Dimethoxybenzaldehyde
CAS编号86-51-1
MFCD编号:MFCD00003309
EINECS号:201-677-7
FDA UNII编号:8ALP3SY00L
分子式:C9H10O3
分子量:166.17
产品CID: 1867360
产品分类有机原料→分子砌块→芳环类化合物→苯类化合物

相似结构搜索
InChIKey: JIVGSHFYXPRRSZ-UHFFFAOYSA-N
InChI=1S/C9H10O3/c1-11-8-5-3-4-7(6-10)9(8)12-2/h3-6H,1-2H3…
计算化学: 氢键受体数3.0氢键供体数0.0可旋转键数3.0

物理性质

熔点48-52°C
沸点137°C at 760 mmHg
闪点113°C
密度1.1±0.1 g/cm3
PSA:35.53
LogP:1.5163
折射率1.534
蒸汽压0.0±0.5 mmHg at 25°C
溶解性Solubility In Methanol With Almost Transparency.
敏感性空气敏感
外观形态类白色至米色结晶粉末、晶体和/或块状物
储存条件置于阴暗处,密封, 常温干燥保存
产品应用该品为有机合成中间体,医药工业用于合成黄连素等.
性质描述无色或白色针状结晶.熔点54°C,沸点256°C(99.3kPa),137°C(1.6kPa).不溶于水,溶于醇.

MSDS等安全信息

GHS象形图
GHS符号GHS07;
注释: Exclamation mark
危险类别特定目标器官毒性 - 单次接触类别3
皮肤腐蚀/刺激类别2
严重眼刺激类别2
严重眼刺激类别2A
警示词Warning(警告)
危险描述H335 |可能引起呼吸道刺激.
H315 |造成皮肤刺激.
H319 |造成严重眼刺激.
防范说明P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
UN编号NONH for all modes of transport
危险品标志Xi
风险等级Irritant
安全声明26-36
危险类别码36/37/38
WGK Germany3

欧盟法规

ECHA物质C&L通报REACH预注册

上下游产品

合成工艺路线路线简述

合成目标产物 2,3-Dimethoxybenzaldehyde 主要起始原料 Formaldehyde And 1,2-Dimethoxybenzene
5653-67-8 = 86-51-1
反应条件:1.1 Reagents: Phosphonium,Triphenyl(Phenylmethyl)-,Chlorate (1:1) Catalysts: Aluminum Chloride Solvents: Acetonitrile
标题:Oxidation Of Alcohols With Benzyltriphenylphosphonium Chlorate Under Non-Aqueous Conditions
作者:Hajipour,A. R.; Et Al
参考文献:Phosphorus 日期:2001 卷标:176 页码:1-7]

5653-67-8 = 86-51-1
反应条件:1.1 Reagents: Oxygen Catalysts: Potassium Tert-Butoxide,Tempo,Copper Bromide (Cubr2),Poly[oxy(Dimethylsilylene)],α-[dimethyl[3-[(2-Pyridinylmethylene)Amino]Propyl]S... Solvents: Acetonitrile,Water; 4 H,25 °C
标题:Room Temperature Aerobic Oxidation Of Alcohols Using Cubr2 With Tempo And A Tetradentate Polymer Based Pyridyl-Imine Ligand
作者:Hu,Zhenzhong; Et Al
参考文献:Applied Catalysis 日期:2012 卷标:413 页码:413-414]

1214-54-6 = 86-51-1
反应条件:1.1 Solvents: Tetrahydrofuran; Rt -> 0 °C1.2 Solvents: Tetrahydrofuran; 0 °C -> Rt1.3 Reagents: Hydrochloric Acid Solvents: Water; Rt
标题:Probing Persistent Intramolecular C-H...X (X = O,S,Br,Cl,And F) Bonding In Solution Using Benzyl Meldrum'S Acid Derivatives
作者:Fillion,Eric; Et Al
参考文献:Journal Of Organic Chemistry 日期:2009 卷标:74(3) 页码:1259-1267]

148-53-8 = 86-51-1
反应条件:1.1 Reagents: Potassium Carbonate Solvents: Dimethylformamide; 42 H,45 °C
标题:Synthesis And Properties Of Bimetallic Hoveyda-Grubbs Metathesis Catalysts
作者:Grudzien,Krzysztof; Et Al
参考文献:Organometallics 日期:2012 卷标:31(9) 页码:3636-3646]

148-53-8 = 86-51-1
反应条件:1.1 Reagents: Potassium Carbonate Solvents: Dimethylformamide; 23 H,60 °C
标题:Studies On Synthesis Of Quinonylidene Hoveyda-Type Complexes
作者:Grudzien,Krzysztof; Et Al
参考文献:Applied Organometallic Chemistry 日期:2015 卷标:29(5) 页码:322-327]

148-53-8 = 86-51-1
反应条件:1.1 Reagents: Potassium Hydroxide Solvents: Water
标题:The 2-Aminotetralin System As A Structural Base For New Dopamine- And Melatonin-Receptor Agents
作者:Copinga,Swier
参考文献:1994]

= 86-51-1
反应条件:1.1 Reagents: Boron Tribromide Solvents: Dichloromethane
标题:Synthesis Of Potentially Carcinogenic Higher Oxidized Metabolites Of Dibenz[a,J]Anthracene And Benzo[c]Chrysene
作者:Harvey,Ronald G.; Et Al
参考文献:Journal Of Organic Chemistry 日期:1998 卷标:63(23) 页码:8118-8124]

148-53-8 = 86-51-1
反应条件:1.1 Catalysts: Potassium Carbonate; Rt -> 150 °C; 11 H,150 °C
标题:Study On Green Synthesis Of O-Veratraldehyde
作者:Pan,Shu-Gang; Et Al
参考文献:Anhui Nongye Kexue 日期:2009 卷标:37(1) 页码:13-15]

25245-33-4 = 86-51-1
反应条件:1.1 Reagents: Triphenylphosphine,Iodine Solvents: Toluene; 10 Min,Rt1.2 Reagents: Triethylamine Catalysts: Palladium Diacetate; 4 H,80 °C
标题:Palladium-Catalyzed Formylation Of Aryl Iodides With Hcooh As Co Source
作者:Sun,Guanglong; Et Al
参考文献:Organic Letters 日期:2017 卷标:19(16) 页码:4235-4238]

106686-63-9 = 86-51-1
反应条件:1.1 Reagents: Sulfuric Acid,Dipotassium Chromate (K2Cro4) Solvents: Water
标题:The Synthesis Of 2,3-Dimethoxybenzaldehyde (ο-Veratraldehyde)
作者:Nagai,Yoshio; Et Al
参考文献:Nippon Kagaku Kaishi (1921-47) 日期:1952 页码:45-6]

5653-67-8 = 86-51-1
反应条件:1.1 Reagents: 4-Aza-1-Azoniabicyclo[2.2.2]Octane,1-Butyl-,(T-4)-Chlorotrioxochromate(1-) Catalysts: Aluminum Chloride Solvents: Acetonitrile; 2 H,Reflux
标题:Oxidation Of Alcohols With 1-Butyl-4-Aza-1-Azoniabicyclo[2.2.2]Octane Chlorochromate (Baaocc) Under Non-Aqueous Conditions
作者:Hajipour,Abdol R.; Et Al
参考文献:Indian Journal Of Chemistry 日期:2005 卷标:(3) 页码:577-580]

148-53-8 = 86-51-1
反应条件:1.1 Reagents: Potassium Carbonate Solvents: Dimethylformamide; 16 H,60 °C
标题:New Short Synthesis Of (5)-2,3-Dimethoxy-N-[(1-Ethyl-2-Pyrrolidinyl)Methyl]-5-Iodobenzamide. Dopamine D2 Receptor
作者:Joshua,Alummoottil V.; Et Al
参考文献:Synthetic Communications 日期:2008 卷标:38(3) 页码:434-440]

148-53-8 = 86-51-1
反应条件:1.1 Reagents: Potassium Carbonate Solvents: Benzene
标题:A Synthesis Of The Phenolic Lipid,3-[(Z)-Pentadec-8-Enyl] Catechol,(15:1)-Urushiol
作者:Tyman,John H. P.; Et Al
参考文献:Chemistry And Physics Of Lipids 日期:2002 卷标:120(1-2) 页码:101-108]

148-53-8 = 86-51-1 [标题:Reaction Conditions
标题:Electron-Impact Induced Loss Of C-5 And C-8 Substituents In 1,2,3,4-Tetrahydroisoquinolines. Ii: Synthesis Of C-8 Substituted 1,2,3,4-Tetrahydroisoquinolines
作者:Mayer,Klaus K.; Et Al
参考文献:Archiv Der Pharmazie (Weinheim 日期:1983 卷标:316(9) 页码:801-12]

560094-94-2 = 86-51-1
反应条件:1.1 Catalysts: Bismuth Triflate Solvents: Dichloromethane,Water; 10 Min,Rt
标题:An Efficient Catalytic Deprotection Of Thioacetals Employing Bismuth Triflate: Synthesis Of Pyrrolo[2,1-C] [1,4] Benzodiazepines
作者:Kamal,Ahmed; Et Al
参考文献:Tetrahedron Letters 日期:2003 卷标:44(14) 页码:2857-2860]

10210-68-1 = 86-51-1
反应条件:1.1 Reagents: Sodium Acetate,Triethylsilane Catalysts: Dichloro[1,1′-Bis(Diphenylphosphino)Ferrocene]Palladium(Ii) Dichloromethane Addu... Solvents: Acetonitrile; 16 H,Rt
标题:Palladium-Catalyzed Reductive Carbonylation Of (Hetero)Aryl Halides And Triflates Using Cobalt Carbonyl As Co Source
作者:Dogga,Bhushanarao; Et Al
参考文献:European Journal Of Organic Chemistry 日期:2021 卷标:2021(2) 页码:309-313]

10210-68-1 = 86-51-1
反应条件:1.1 Reagents: Potassium Acetate,Triethylsilane Catalysts: Palladium Diacetate,1,1′-(9,9-Dimethyl-9H-Xanthene-4,5-Diyl)Bis[1,1-Diphenylphosphine] Solvents: 1,4-Dioxane; 12 H,50 °C
标题:Room Temperature Carbonylation Of (Hetero) Aryl Pentafluorobenzenesulfonates And Triflates Using Palladium-Cobalt Bimetallic Catalyst: Dual Role Of Cobalt Carbonyl
作者:Joseph,Jayan T.; Et Al
参考文献:Advanced Synthesis & Catalysis 日期:2017 卷标:359(3) 页码:419-425]

24677-78-9 = 86-51-1
反应条件:1.1 Reagents: Potassium Carbonate Solvents: Dimethylformamide; 1 H,80 °C
标题:Design,Synthesis And Evaluation Of Curcumin-Based Fluorescent Probes To Detect Aβ Fibrils
作者:Sato,Taki; Et Al
参考文献:Bioorganic & Medicinal Chemistry Letters 日期:2018 卷标:28(22) 页码:3520-3525]

1521-38-6 = 86-51-1
反应条件:1.1 Reagents: Chlorotrimethylsilane,Triethylamine Solvents: Dichloromethane1.2 Reagents: Diisobutylaluminum Hydride
标题:One Pot Conversion Of Carboxylic Acids To Aldehydes With Dibal-H
作者:Chandrasekhar,S.; Et Al
参考文献:Tetrahedron Letters 日期:1998 卷标:39(8) 页码:909-910]

1521-38-6 = 86-51-1 [标题:Reaction Conditions
标题:Aliphatic And Alicyclic Aldehydes: Synthesis By Reduction Or By Reduction Followed By Hydrolysis
作者:Harcken,C.
参考文献:Science Of Synthesis 日期:2007 卷标:25 页码:65-135]

148-53-8 = 86-51-1
反应条件:1.1 Reagents: Dimethyl Sulfate,Potassium Carbonate Solvents: Acetone
标题:Synthesis Of β-(2,3-Dihydroxybenzoyl)Butyric Acid
作者:Wang,Dexin; Et Al
参考文献:Huaxue Xuebao 日期:1986 卷标:44(7) 页码:692-4]

93-51-6 = 86-51-1 [标题:Reaction Conditions
标题:A New Synthesis Of Anthraquinones Using Dihydrooxazoles And Grignard Reagents Derived From Mg(Anthracene)(Thf)3
作者:Nicoletti,Teresa M.; Et Al
参考文献:Journal Of The Chemical Society 日期:1990 卷标:(1) 页码:133-8]

94936-90-0 = 86-51-1
反应条件:1.1 Reagents: Hydrochloric Acid,Water Solvents: Water
标题:Stability Study And Structure Determination Of Degradation Products Of A New Positive Inotropic Agent,E-6-(3,4-Dimethoxyphenyl)-1-Ethyl-4-Mesitylimino-3-Methyl-3,4-Dihydro-2(1H)-Pyrimidinone (Fr58664),In Acidic Solution
作者:Kitamura,Satoshi; Et Al
参考文献:Iyakuhin Kenkyu 日期:1990 卷标:21(5) 页码:982-8

1-[bis(Ethylsulfanyl)Methyl]-2,3-Dimethoxybenzene置于bismuth(Lll) Trifluoromethanesulfonate体系中,用二氯甲烷,水作为反应溶剂,化学反应 0.17H,以90%的收率获得产物2,3-二甲氧基苯甲醛
参考文献:使用三氟甲基磺酸铋有效催化脱硫基缩醛的保护反应:吡咯并[2,1-C] [1,4]苯并二氮杂synthesis的合成
标题:使用三氟甲基磺酸铋有效催化脱硫基缩醛的保护反应:吡咯并[2,1-C] [1,4]苯并二氮杂synthesis的合成
摘要:通过使用三氟甲磺酸铋已经实现了对硫缩醛的简单有效的脱保护.该方法已有效地用于制备结合dna的吡咯并[2,1-C] [1,4]苯并二氮杂及其二聚体.
DOI:10.1016/s0040-4039(03)00437-4

海关参考信息

2905110000-甲醇
2907210001-间苯二酚
2912110000-甲醛
2912210000-苯甲醛
💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
详情请参考：📖 海关编码查询和海关进出口税则

专利信息

专利号:US-10266565-B2
优先权日:2011-04-12
标题 :Peptide mimetic ligands of polo-like kinase 1 polo box domain and methods of use
发明人：BURKE JR TERRENCE R; LIU FA; LEE KYUNG S; PARK JUNG-EUN
权利人:BURKE JR TERRENCE R; LIU FA; LEE KYUNG S; PARK JUNG EUN; THE US SECRETARY DEPARTMENT OF HEALTH & HUMAN SERVICES
摘要:Novel compounds are provided that bind to polo-like kinases through the polo-box domain. In certain embodiments, the novel compounds are PEGylated peptides. The PEGylated peptides in accordance with the invention demonstrate high PBD-binding affinity. In certain embodiments, the PEGylated peptides have also achieved activities in whole cell systems. The invention also provides compounds that bind polo-like kinases through the polo-box domain and possess reduced anionic charge. Further provided are methods of design and/or synthesis of the PEGylated peptides and methods of use thereof. The invention provides methods of use of the compounds and methods of synthesis of the compounds.

专利号:US-2024400533-A1
优先权日:2023-06-02
标题 :General Solid-Phase Synthesis of Crown Ethers
发明人：TRANT JOHN F; NASRI SARAH; HAYWARD JOHN J
权利人:UNIV OF WINDSOR
摘要:In a preferred embodiment, there is provided a method for preparing a crown ether, the method comprising: loading a resin having a resin functional group with a linking compound having a functional group selected for coupling to the resin functional group and at least two carbon atoms each having a substituent; coupling the linking compound to a polyethylene glycol having two terminal carbon atoms each bonded to an optionally protected terminal hydroxyl group to obtain a cyclized intermediate, whereby one said at least two carbon atoms or the substituent and an associated one of the two terminal carbon atoms or the hydroxyl groups undergo a coupling or substitution reaction; and removing the linking compound and the cyclized intermediate from the resin.

专利号:US-5175302-A
优先权日:1987-07-13
标题 :Nucleophilic fluoroalkylation of aldehydes
发明人：STAHLY G PATRICK
权利人:ETHYL CORP
摘要:Aryl difluoromethyl sulfone adds to aldehydes under phase transfer conditions to give novel substituted alcohols of the general formula n n RCH(OH)CF.sub.2 SO.sub.2 Ar (I) n n wherein R is an aryl, cycloaliphatic, sec- or tert-aliphatic, or heterocyclic group and Ar is an aryl group. The substituted alcohols of formula I are of particular utility as intermediates in the synthesis of a variety of useful end products. For example, the products of formula I may be utilized in desulfonylation reactions, oxidation reactions and fluorination reactions.

专利号:US-2021284618-A1
优先权日:2016-08-12
标题 :Furanochalcones as inhibitors of cyp1a1, cyp1a2 and cyp1b1 for cancer chemoprevention
发明人：BHARATE SANDIP BIBISHAN; SHARMA RAJNI; JOSHI PRASHANT; VISHWAKARMA RAM; CHAUDHURI BHABATOSH
权利人:COUNCIL SCIENT IND RES; DE MONTFORT UNIV
摘要:The present invention relates to the furanochalcone class of compounds of general formula A. The present invention particularly relates to the synthesis of furanochalcones and their CYP1A1, CYP1A2 and CYP1B1 inhibitory activity. In addition, the invention relates to the prevention or treatment of cancer caused by polyaromatic hydrocarbons (PAHs), 4-nitroquinoline-1-oxide, and N-nitroso-N-methylurea, heterocyclic amines, estrogen and 17Î²-estradiol, resulting from the inhibition of CYP1A1, CYP1A2 and CYP1B1 enzymes.

专利号:US-4837327-A
优先权日:1987-07-13
标题 :Process for nucleophilic fluoroalkylation of aldehydes
发明人：STAHLY G PATRICK
权利人:ETHYL CORP
摘要:Aryl difluoromethyl sulfone adds to alkehydes under phase transfer conditions to give novel substituted alcohols of the general formula n n RCH(OH)CF.sub.2 SO.sub.2 Ar (I) n n wherein R is an aryl, cycloaliphatic, sec- or tert-aliphatic, or heterocyclic group and Ar is an aryl group. The substituted alcohols of formula I are of particular utility as intermediates in the synthesis of a variety of useful end products. For example, the products of formula I may be utilized in desulfonylation reactions, oxidation reactions and fluorination reactions.

专利号:US-4999429-A
优先权日:1989-01-09
标题 :Process for the preparation of Î±,Î±,Î²-1-trifluoro-1-olefinic derivatives
发明人：STAHLY G PATRICK
权利人:ETHYL CORP
摘要:Aryl difluoromethyl sulfone adds to aldehydes under phase transfer conditions to give novel substituted alcohols of the general formula n n RCH(OH)CF.sub.2 SO.sub.2 Ar (I) n n wherein R is an aryl, cycloaliphatic, sec- or tert-aliphatic, or heterocyclic group and Ar is an aryl group. The substituted alcohols of formula I are of particular utility as intermediates in the synthesis of a variety of useful end products. For example, the products of formula I may be utilized in desulfonylation reactions, oxidation reactions and fluorination reactions.

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邻藜芦醛

2,3-Dimethoxybenzaldehyde

98%|25kg/drum|500kg|现货|淡黄色结晶性粉末
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✅ COA系统入驻 | 共享模式

主要参考文献

[参考文献]: Kim Jh, Et Al. Antifungal Activity Of Redox-Active Benzaldehydes That Target Cellular Antioxidation. Ann Clin Microbiol Antimicrob.
[参考文献]: Jong H Kim, Et Al. Antifungal Activity Of Redox-Active Benzaldehydes That Target Cellular Antioxidation. Ann Clin Microbiol Antimicrob. 2011 May 31:10:23.

合成参考文献

参考文献:10.1107/s1600536811013894
摘要:Xin X, Li M, Chen Z, Zhu R. 1-(2,3-Dimeth-oxy-benzyl-idene)-2-(2,4-dinitro-phen-yl)hydrazine. Acta Crystallogr Sect E Struct Rep Online. 2011 May 01;67(Pt 5):o1169.

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CAS: 86-51-1; 2,3-Dimethoxybenzaldehyde

该化合物是一种多用途芳香甲醚,有两种甲氧替代物.它具有极佳的稳定性和高纯度,因此适合有机合成.它有助于各种反应,包括核生殖添加和环闭反应,因为其反应性芳香系统.它的确切结构和纯度确保了研究和工业应用的可靠性能.

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