CAS: 86401-95-8; Methylprednisolone Aceponate
该化合物是一种具有抗炎和免疫抑制特性的合成花生类固醇,主要用于皮肤病治疗各种皮肤病,包括乙酰胺和psorpical,该化合物的特点是能够减少炎症和调制免疫反应,使其有效地管理过敏反应和自免疫紊乱.甲基甲虫酮乙酸酯通常是一种局部性准备,允许在最低限度的系统吸收的情况下进行局部治疗.其化学结构包括一种用丙烯酮酯酯改造的甲虫酮脊椎,这提高了其皮肤的渗透度和能性.该物质一般都具有良好的耐燃性,但与其他甲虫菊酯一样,可能会产生副作用,如皮肤减瘦或长期使用刺激.由于其功效和有利的药用皮肤病简介,甲基甲虫酮乙酸酯是治疗性皮肤疾病的一种宝贵的选择.
- 英文名称Methylprednisolone Aceponate
- 中文名称甲基泼尼松龙乙丙酸酯
- IUPAC名称(6S,8S,9R,11S,13S,14S,17R)-17-(2-acetoxyacetyl)-11-hydroxy-6,10,13-trimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-17-yl propionate
- 其它别名[(6S,8R,9R,10S,11S,13S,14S,17R)-17-(2-Acetyloxyacetyl)-11-hydroxy-6,10,13-trimethyl-3-oxo-7,8,9,11,12,14,15,16-°Ctahydro-6H-cyclopenta[a]phenanthren-17-yl] propanoate
- CAS编号86401-95-8
- MFCD编号:MFCD00866150
- EINECS号:658-084-5
- FDA UNII编号:ET54W9J4U2
- 分子式:C27H36O7
- 分子量:472.57
- 产品CID: 1865486
- 产品分类有机原料 → 羧酸类化合物及衍生物
物理性质
- 熔点105 - 108°C
- 沸点595.8±50.0 °C at 760 mmHg
- 闪点193.1±23.6 °C
- 密度1.2±0.1 g/cm3
- pKa:14.05±0.70(预测)
- PSA:106.97
- LogP:4.01
- 折射率1.560
- 蒸汽压0.0±3.8 mmHg at 25°C
- 溶解性Chloroform (Slightly), Dioxane (Slightly), DMSO (Slightly), Ethyl Acetate(Slightly)
- 外观形态白色至类白色固体
- 储存条件密封, 常温干燥保存
- 产品应用抗炎作用较强,对钠潴留作用微弱,作用同泼尼松.1.甲基氢化泼尼松醋酸酯混悬剂分解缓慢,作用持久,可供肌内,关节腔内注射.2.甲基氢化泼尼松琥珀酸钠为水溶性,可供肌注,或溶于葡萄糖液中静脉滴注.因半衰期短,故治疗严重休克时,应于4小时后重复给药.
- 性质描述白色或类白色晶体,熔点241.0°C～243.0°C,旋光度+79.0°～+86.0°
MSDS等安全信息
欧盟法规
ECHA物质C&L通报上下游产品
CAS号86413-47-0 21-acetoxy-6α-m... | CAS号79512-61-1 6α-甲基泼尼松龙17-丙酸酯 | CAS号86413-24-3 17α,21-diacetox... | CAS号85198-27-2 6α-甲基泼尼松龙17,21-原丙酸乙酯 | CAS号108-24-7 乙酸酐合成工艺路线路线简述
- 合成目标产物 Methylprednisolone Aceponate 主要起始原料 Methylprednisolone Ethylothopropionate
- 79512-61-1 = 86401-95-8
反应条件:1.1 Reagents: Triethylamine Solvents: Dichloromethane
标题:Studies On Topical Antiinflammatory Corticosteroids. I. Syntheses And Vasoconstrictive Activities Of 11β,17α,21-Trihydroxy-6α-Methyl-1,4-Pregnadiene-3,20-Dione 17-Ester And 17,21-Diester Derivatives
作者:Sugai,Saburo; Et Al
参考文献:Chemical & Pharmaceutical Bulletin 日期:1985 卷标:33(5) 页码:1889-98]
85198-27-2 = 86401-95-8
反应条件:1.1 Reagents: Oxalic Acid Solvents: Methanol,Water2.1 Reagents: Triethylamine Solvents: Dichloromethane
标题:Studies On Topical Antiinflammatory Corticosteroids. I. Syntheses And Vasoconstrictive Activities Of 11β,17α,21-Trihydroxy-6α-Methyl-1,4-Pregnadiene-3,20-Dione 17-Ester And 17,21-Diester Derivatives
作者:Sugai,Saburo; Et Al
参考文献:Chemical & Pharmaceutical Bulletin 日期:1985 卷标:33(5) 页码:1889-98]
99598-76-2 = 86401-95-8
反应条件:1.1 Reagents: Oxalic Acid Solvents: Methanol,Water2.1 Reagents: Triethylamine Solvents: Dichloromethane
标题:Studies On Topical Antiinflammatory Corticosteroids. I. Syntheses And Vasoconstrictive Activities Of 11β,17α,21-Trihydroxy-6α-Methyl-1,4-Pregnadiene-3,20-Dione 17-Ester And 17,21-Diester Derivatives
作者:Sugai,Saburo; Et Al
参考文献:Chemical & Pharmaceutical Bulletin 日期:1985 卷标:33(5) 页码:1889-98]
83-43-2 = 86401-95-8 [标题:Reaction Conditions
标题:6α-Methylprednisolone Derivatives And Their Utilization
参考文献:European Patent Organization
6α-甲基泼尼松龙17,21-原丙酸乙酯置于草酸,三乙胺体系中,用 甲醇,二氯甲烷 作为反应溶剂,化学反应 3.17H,反应生成 甲基泼尼松龙乙丙酸酯
参考文献:Studies On Topical Antiinflammatory Corticosteroids. I. Syntheses And Vasoconstrictive Activities Of 11.Beta.,17.Alpha.,21-Trihydroxy-6.Alpha.-Methyl-1,4-Pregnadiene-3,20-Dione 17-Ester And 17,21-Diester Derivatives.
标题:Studies On Topical Antiinflammatory Corticosteroids. I. Syntheses And Vasoconstrictive Activities Of 11.Beta.,17.Alpha.,21-Trihydroxy-6.Alpha.-Methyl-1,4-Pregnadiene-3,20-Dione 17-Ester And 17,21-Diester Derivatives.
摘要:合成了11β,17α,21-三羟基-6α-甲基-1,4-孕甾二烯-3,20-二酮(6α-甲基泼尼松龙,1)的七个17-酯和三十八个17,21-二酯化合物(3和4).对三十八个选定的化合物进行了人体血管收缩活性测试.除了4G1和4G2以外,它们的活性都比母体化合物(1)更强.特别是十个化合物(3B-G,4B9,10,4C2,3和4C6)的活性等于或超过9α-氟-11β,21-二羟基-16β-甲基-17α-戊酸酯-1,4-孕甾二烯-3,20-二酮(倍他米松17-戊酸酯,Bv).21-甲氧乙酸酯化合物(4B9,4C6和4D5)的活性很强.讨论了结构-活性关系.
DOI:10.1248/cpb.33.1889
海关参考信息
- 2901210000-乙烯
2901220000-丙烯
2905122000-异丙醇
2905143000-叔丁醇 - 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
- 详情请参考：📖 海关编码查询和海关进出口税则
专利信息
专利号:US-8697730-B2
优先权日:2007-10-26
标题 :5-lipoxygenase activating protein (FLAP) inhibitor
发明人：REWOLINSKI MELISSA VIRGINIA; SCHAAB KEVIN MURRAY; KING CHRISTOPHER DAVID; STOCK NICHOLAS SIMON
权利人:REWOLINSKI MELISSA VIRGINIA; SCHAAB KEVIN MURRAY; KING CHRISTOPHER DAVID; STOCK NICHOLAS SIMON; PANMIRA PHARMACEUTICALS LLC
摘要:Described herein are methods for the synthesis of 3-[5-(pyridin-2-ylmethoxy)-3-(2-methyl-2-propylthio)-1-[4-(2-methoxypyridin-5-yl)benzyl]-indol-2-yl]-2,2-dimethyl-propionic acid, pharmaceutically acceptable salts, pharmaceutically acceptable solvates thereof. Also described are pharmaceutical compositions suitable for oral administration to a mammal that include, as well as methods of using such oral pharmaceutical compositions for treating respiratory conditions or diseases, as well as other leukotriene-dependent or leukotriene mediated conditions or diseases.
专利号:US-2012232031-A1
优先权日:2009-10-19
标 题:Injectable formulations for intra-articular or peri-articular administration
发明人：HUTCHINSON JOHN HOWARD; PRASIT PETPIBOON PEPPI; DEARMOND ISABELLE MARGUERITE
权利人:HUTCHINSON JOHN HOWARD; PRASIT PETPIBOON PEPPI; DEARMOND ISABELLE MARGUERITE; PANMIRA PHARMACEUTICALS LLC
摘要:Described herein are injectable formulations for intra-articular or peri-articular administration, wherein the formulation is administered to treat joint pain. An injectable formulation for intra-articular or peri-articular administration disclosed herein comprises a therapeutically-effective amount of a leukotriene synthesis inhibitor compound formulated for intra-articular or peri-articular administration.
网址: http://www.chinahormone.com
电话: 0086-571-85215532/18167103925👤
销售电话:0086-571-85215532/18167103925
邮箱： taifa@chinahormone.com
电话: 0086-571-85215532/18167103925👤
📞台州百大药业有限公司 ⚠️参考联系方式
销售电话:0086-571-85215532/18167103925
邮箱： taifa@chinahormone.com
🆔 联系时候可告知是从"百琢研"平台获取的信息.
⚠️ 声明: 该企业未认证、未认领，请自行辨别信息的真实性和可靠性。咨询或交易时请注意风险评估与信息核实，百琢研不参与任何交易。企业认领注册入口→
⚠️ 未注册 · 未认证企业
备注: 📌 数据来源说明：本展台内容基于各搜索引擎等公开数据整理，仅作展示用途。请用户自行辨别 ✉️ 若企业需抹除展台内容或有异议， 请通过页面底部联系方式告知我们，我们会尽快处理。网址: http://www.xjpharma.com
电话: 0576-87772810👤
销售电话:0576-87772810
邮箱：online@xjpharma.com
电话: 0576-87772810👤
📞浙江仙琚制药股份有限公司 ⚠️参考联系方式
销售电话:0576-87772810
邮箱：online@xjpharma.com
🆔 联系时候可告知是从"百琢研"平台获取的信息.
⚠️ 声明: 该企业未认证、未认领，请自行辨别信息的真实性和可靠性。咨询或交易时请注意风险评估与信息核实，百琢研不参与任何交易。企业认领注册入口→
⚠️ 未注册 · 未认证企业
备注: 📌 数据来源说明：本展台内容基于各搜索引擎等公开数据整理，仅作展示用途。请用户自行辨别 ✉️ 若企业需抹除展台内容或有异议， 请通过页面底部联系方式告知我们，我们会尽快处理。网址: http://www.huaxinpharm.com
电话: 0086-576-87085380 13136582221👤
销售电话:0086-576-87085380 13136582221
邮箱：qjw620@163.com
电话: 0086-576-87085380 13136582221👤
📞江西东乡华鑫医药化工有限公司 ⚠️参考联系方式
销售电话:0086-576-87085380 13136582221
邮箱：qjw620@163.com
🆔 联系时候可告知是从"百琢研"平台获取的信息.
⚠️ 声明: 该企业未认证、未认领，请自行辨别信息的真实性和可靠性。咨询或交易时请注意风险评估与信息核实，百琢研不参与任何交易。企业认领注册入口→
⚠️ 未注册 · 未认证企业
备注: 📌 数据来源说明：本展台内容基于各搜索引擎等公开数据整理，仅作展示用途。请用户自行辨别 ✉️ 若企业需抹除展台内容或有异议， 请通过页面底部联系方式告知我们，我们会尽快处理。第 1 / 1 页
供应商参考报价(招募中)
品牌试剂参考报价(招募中)
📌 第三方产品分析报告
主要参考文献
1: Fölster-Holst R, Abeck D, Torrelo A. Topical hydrocortisone 17-butyrate 21-propionate in the treatment of inflammatory skin diseases: pharmacological data, clinical efficacy, safety and calculation of the therapeutic index. Pharmazie. 2016 Mar;71(3):115-21. Review. doi: 10.1111/pai.12115. Review. doi: 10.1111/j.1468-3083.2012.04711.x. Review. doi: 10.1111/j.1468-3083.2012.04710.x. Review. doi: 10.1111/j.1468-3083.2011.04195.x. Epub 2011 Oct 7. Review. doi: 10.1111/j.1468-3083.2010.03942.x. Review. doi: 10.1111/j.1468-3083.2010.03789.x. Review. doi: 10.1111/j.1365-2133.2010.10030.x. Epub 2010 Nov 23. Review. Review. Spanish. Review. Review. Review. Review.
合成参考文献
摘要:S76 | LUXPHARMA | Pharmaceuticals Marketed in Luxembourg | Pharmaceuticals marketed in Luxembourg, as published by d'Gesondheetskeess (CNS, la caisse nationale de sante, www.cns.lu), mapped by name to structures using CompTox by R. Singh et al. (2021) DOI:10.1021/acsenvironau.1c00008. List downloaded from
参考文献:10.1007/s00520-006-0063-4
摘要:Bolderston A, Lloyd NS, Wong RK, Holden L, Robb-Blenderman L; Supportive Care Guidelines Group of Cancer Care Ontario Program in Evidence-Based Care. The prevention and management of acute skin reactions related to radiation therapy: a systematic review and practice guideline. Support Care Cancer. 2006 Aug;14(8):802–17. doi: 10.1007/s00520-006-0063-4.
参考文献:10.1111/j.1440-0960.2010.00655.x
摘要:Moche J, Glassman S, Modi D, Grayson W. Segmental lichen aureus: a report of two cases treated with methylprednisolone aceponate. Australas J Dermatol. 2011 May;52(2):e15–8. doi: 10.1111/j.1440-0960.2010.00655.x.
参考文献:10.1007/s002280050193
摘要:Letawe C, Piérard-Franchimont C, Piérard GE. Squamometry in rating the efficacy of topical corticosteroids in atopic dermatitis. European Journal of Clinical Pharmacology. 1996 Dec 12;51(3-4):253–7. doi: 10.1007/s002280050193.
📝 需求与反馈
尽可能描述清楚需求与问题信息
