专利号:US-9834556-B2 优先权日:2014-03-24 标题 :Process of preparing 3-(3-(4-aminocyclobutyl)phenyl)-5-phenyl-3H-imidazo[4,5-B]pyridin-2-YL)pyridin-2-amine 发明人:BATES CRAIG; CHEN JIAN-XIE; MAO JIANMIN; REED DAVID P 权利人:ARQULE INC 摘要:The present invention is directed to a processes for the synthesis of 3-(3-(4-(1-aminocyclobutyl)phenyl)-5-phenyl-3H-imidazo[4,5-b]pyridin-2-yl)pyridin-2-amine:
专利号:US-7816375-B2 优先权日:2000-09-11 标 题 :Ligands for monoamine receptors and transporters, and methods of use thereof 发明人:AQUILA BRIAN M; BANNISTER THOMAS D; CUNY GREGORY D; HAUSKE JAMES R; HOLLAND JOANNE M; PERSONS PAUL E; RADEKE HEIKE; WANG FENGJIANG; SHAO LIMING 权利人:SEPRACOR INC 摘要:One aspect of the present invention relates to heterocyclic compounds. A second aspect of the present invention relates to the use of the heterocyclic compounds as ligands for various mammalian cellular receptors, including dopamine, serotonin, or norepinephrine transporters. The compounds of the present invention will find use in the treatment of numerous ailments, conditions and diseases which afflict mammals, including but not limited to addiction, anxiety, depression, sexual dysfunction, hypertension, migraine, Alzheimer's disease, obesity, emesis, psychosis, schizophrenia, Parkinson's disease, inflammatory pain, neuropathic pain, Lesche-Nyhane disease, Wilson's disease, and Tourette's syndrome. An additional aspect of the present invention relates to the synthesis of combinatorial libraries of the heterocyclic compounds, and the screening of those libraries for biological activity, e.g., in assays based on dopamine transporters.
专利号:US-9695116-B2 优先权日:2011-12-30 标题:Compositions, synthesis, and methods of using phenylcycloalkylmethylamine derivatives 发明人:BHAT LAXMINARAYAN; ADIEY KOUACOU; BHAT SEEMA RANI 权利人:REVIVA PHARMACEUTICALS INC 摘要:The present invention provides novel phenylcycloalkylmethylamine derivatives, and methods of preparing phenylcycloalkylmethylamine derivatives. The present invention also provides methods of using phenylcycloalkylmethylamine derivatives and compositions of phenylcycloalkylmethylamine derivatives. The pharmaceutical compositions of the compounds of the present invention can be used for treating and/or preventing obesity and obesity related co-morbid indications and depression and depression related co-morbid indications.
专利号:US-9302981-B2 优先权日:2006-09-15 标 题:Synthesis, methods of using, and compositions of cycloalkylmethylamines 发明人:BHAT LAXMINARAYAN; BHAT SEEMA RANI 权利人:REVIVA PHARMACEUTICALS INC 摘要:The present invention provides novel cycloalkylmethylamine analogs, and methods of preparing cycloalkylmethylamine analogs. The present invention also provides methods of using cycloalkylmethylamine analogs and compositions of cycloalkylmethylamine analogs. The pharmaceutical compositions of the compounds of the present invention can be advantageously used for treating and/or preventing obesity and obesity related co-morbid indications.
专利号:US-8669285-B2 优先权日:2006-09-15 标题 :Synthesis, methods of using, and compositions of cycloalkylmethylamines
专利号:US-2008139663-A1 优先权日:2006-09-15 标 题 :Synthesis, methods of using, and compositions of cycloalkylmethylamines
参考标题:Fe(Clo4)3.H2O-Catalyzed Ritter Reaction: A Convenient Synthesis Of Amides From Esters And Nitriles 作者:Min Ji,Chengliang Feng,Bin Yan,Guibo Yin,Junqing Chen |发布日期:2018.10 摘要:An Efficient And Inexpensive Synthesis Of N-Substituted Amides From The Ritter Reaction Of Nitriles With Esters Catalyzed By Fe(Clo4)3.H2O Is Described. Fe(Clo4)3.H2O Is An Economically Efficient Catalyst For The Ritter Reaction Under Solvent-Free Conditions. Reactions Of A Range Of Esters (Benzyl, Sec-Alkyl, And Tert-Butyl Esters) With Nitriles (Primary, Secondary, Tertiary, And Aryl Nitriles) Were