CAS: 1667-01-2; 2',4',6'-Trimethylacetophenone

该化合物是属于氯酮类的有机化合物,其特征为:碳基组(C=O)附属的苯基组和位于芳香环2,4和6个位置的三个甲基组.这一结构有助于其独特的特性,包括其相对低的挥发性以及有机溶剂中的中溶性.该化合物一般是一种色素,可粉色黄色,有甜美味的花粉味,在香味和口味工业中有用.此外,该化合物还作为聚合工艺的光化剂,特别是在紫外线涂层和墨粉中,其化学稳定性和活性在紫外线下使其在各种工业应用中具有价值.安全数据表明,应当谨慎处理,因为它可能会对皮肤和眼睛产生刺激.

结构式图片

相似化合物

89-74-7 2142-76-9 2040-01-9

上下游产品

CAS号769-25-5 2,4,6-三甲基苯乙烯 | CAS号108-24-7 乙酸酐 | CAS号108-67-8 均三甲苯 | CAS号1517-71-1 2-(1-hydroxyeth... | CAS号75-36-5 乙酰氯 | CAS号64-19-7 冰醋酸 | CAS号75-05-8 乙腈 | CAS号480-63-7 2,4,6-三甲基苯甲酸 | CAS号4408-60-0 均三甲苯基乙酸 | CAS号3982-67-0 2-ethyl-1,3,5-t... | CAS号54458-28-5 3-氧代-3-(2,4,6-三... | CAS号3112-46-7 荚基化氧乙醛酸 | CAS号20797-56-2 Benzeneacetic a... | CAS号142472-14-8 1-(4-methoxyphe... | CAS号2047-21-4 3',4',5'-Trimet... | CAS号1667-04-5 2,4,6-三甲基氯苯 | CAS号108-67-8 均三甲苯 | CAS号579-74-8 2'-甲氧基苯乙酮

合成工艺路线路线简述

    2-溴-1-(2,4,6-三甲基-苯基)-乙酮置于二氢吡啶,溶剂黄146体系中,化学反应 5.5H,以53%的收率获得2',4',6'-三甲基苯乙酮
    参考文献:用hantzsch酯进行无催化剂的光驱动还原α-卤代酮
    标题:用hantzsch酯进行无催化剂的光驱动还原α-卤代酮
    摘要:专用于细盐陆教授在他的90之际个生日. 抽象的 研究了可见光照射下α-卤代烃的无催化剂脱卤作用.反应在普通有机溶剂中进行.脱氯的结果极佳,产率高达92%,它也适用于溴化物,其产率更高.该反应可耐受多种底物,特别是芳族酮,包括各种芳基和杂芳基.本文中有两个脂肪族酮的例子,尽管它们的反应性不如芳香族酮. 研究了可见光照射下α-卤代烃的无催化剂脱卤作用.反应在普通有机溶剂中进行.脱氯的结果极佳,产率高达92%,它也适用于溴化物,其产率更高.该反应可耐受多种底物,特别是芳族酮,包括各种芳基和杂芳基.本文中有两个脂肪族酮的例子,尽管它们的反应性不如芳香族酮.
    Doi:10.1055/s-0037-1610629

    海关参考信息

    专利信息


    专利号:US-6005103-A
    优先权日:1993-11-19
    标题 :Pyrone derivatives as protease inhibitors and antiviral agents
    发明人:DOMAGALA JOHN MICHAEL; LUNNEY ELIZABETH; PARA KIMBERLY SUZANNE; PRASAD JOSYULA VENKATA NAGENDR; TAIT BRADLEY DEAN
    权利人:WARNER LAMBERT CO
    摘要:The present invention relates to novel tri- and tetrasubstituted pyrones and related structures which potently inhibit the HIV aspartyl protease blocking HIV infectivity. The pyrone derivatives are useful in the development of therapies for the treatment of bacterial and viral infections and diseases, including AIDS. The present invention is also directed to methods of synthesis of multifunctionalized pyrones and of related structures.

    专利号:CN-108906124-A
    优先权日:2017-03-17
    标 题 :Application of Tricene Rare Earth Metal Complexes as Catalysts in the Synthesis of Ketones and Pinacol-Borane

    专利号:CN-108906124-B
    优先权日:2017-03-17
    标题 :Application of trilocene rare earth metal complexes as catalysts in the synthesis of ketones and pinacol boranes

    专利号:EP-0729465-B1
    优先权日:1993-11-19
    标 题:Pyrone derivatives as protease inhibitors and antiviral agents
    发明人:DOMAGALA JOHN MICHAEL; LUNNEY ELIZABETH; PARA KIMBERLY SUZANNE; PRASAD JOSYULA VENKATA NAGENDR; TAIT BRADLEY DEAN
    权利人:PARKE DAVIS & CO
    摘要:The present invention relates to novel tri- and tetrasubstituted pyrones and related structures which potently inhibit the HIV aspartyl protease blocking HIV infectivity. The pyrone derivatives are useful in the development of therapies for the treatment of bacterial and viral infections and diseases, including AIDS. The present invention is also directed to methods of synthesis of multifunctionalized pyrones and of related structures.

    专利号:CN-111606910-A
    优先权日:2020-06-30
    标 题:A kind of synthesis process of antitumor drug Sapanisertib

    专利号:US-9701686-B2
    优先权日:2009-12-04
    标题:Tricyclopyrazole derivatives
    发明人:DISINGRINI TERESA; MANTEGANI SERGIO; VARASI MARIO
    权利人:NERVIANO MEDICAL SCIENCES SRL
    摘要:Compounds which are tricyclopyrazole derivatives or pharmaceutically acceptable salts thereof, their preparation process and pharmaceutical compositions comprising them are disclosed; these compounds are useful in the treatment of diseases caused by and/or associated with an altered protein kinase activity such as cancer, viral infection, prevention of AIDS development in HIV-infected individuals, cell proliferative disorders, autoimmune and neurodegenerative disorders; also disclosed is a process under Solid Phase Synthesis conditions for preparing the compounds of the invention and chemical libraries comprising a plurality of them.
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    主要参考文献

    参考标题:Chemo- And Regioselective Synthesis Of Acyl-Cyclohexenes By A Tandem Acceptorless Dehydrogenation-[1,5]-Hydride Shift Cascade
    作者:Lewis B. Smith,Roly J. Armstrong,Daniel Matheau-Raven,Timothy J. Donohoe |发布日期:2020.2.5
    摘要:Acceptorless Dehydrogenation Of The Diol Followed By A Redox-Neutral Cascade Process, Which Is Independent Of The Iridium Catalyst. Deuterium Labeling Studies Established That The Key Step Of This Cascade Involves A Novel Base-Mediated [1,5]-Hydride Shift. The Cyclohexenyl Ketone Products Could Readily Be Cleaved Under Mildly Acidic Conditions To Access A Range Of Valuable Substituted Cyclohexene Derivatives

    合成参考文献


    摘要:Petasis, N. A., Science of Synthesis, (2010) 47, 168.
    摘要:Race, N. J.; Patel, H. H.; Sigman, M. S., Science of Synthesis: Catalytic Oxidation in Organic Synthesis, (2017) 1, 430.
    摘要:Munz, D., Science of Synthesis: N-Heterocyclic Carbenes in Catalytic Organic Synthesis, (2016) 2, 272.
    摘要:Elie, M.; Renaud, J.-L.; Gaillard, S., Science of Synthesis: N-Heterocyclic Carbenes in Catalytic Organic Synthesis, (2016) 1, 205.
    摘要:W. M. Schubert and H. K. Latourette. J. Am. Chem. Soc. 74, 1829 (1952).
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