CAS: 195609-18-8; 2-Fluoro-5-Nitrophenylacetic Acid

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CAS号451-82-1 邻氟苯乙酸 | CAS号1000339-92-3 2-氟-5-硝基苯乙腈 | CAS号1021389-31-0 2-氟-5-硝基苯乙醇 | CAS号518057-74-4 5-氨基-2-氟苯乙酸

2-氟-5-硝基苯乙腈置于硫酸体系中,化学反应 1.0H,以75%的收率获得2-氟-5-硝基苯乙酸
参考文献:Benzo‐fused Heterocycles And Carbocycles By Intramolecular S N Ar And Tandem S N 2‐s N Ar Reactions
标题:Benzo‐fused Heterocycles And Carbocycles By Intramolecular S N Ar And Tandem S N 2‐s N Ar Reactions
摘要:Abstractmagnified Imagebenzo‐fused Heterocyclic And Carbocyclic Systems Have Been Synthesized By Intramolecular Snar And Tandem Sn2‐snar Reactions. Treatment Of 3‐(2‐fluoro‐5‐nitrophenyl)‐1‐propanol With Sodium Hydride In N,N‐dimethylformamide Gave 6‐nitrochroman In 80% Yield By An Intramolecular Snar Reaction. Treatment Of 2‐(3‐bromopropyl)‐1‐fluoro‐4‐nitrobenzene With Benzylamine In N,N‐dimethylformamide Gave 1‐benzyl‐6‐nitrotetrahydroquinoline In 98% Yield By A Tandem Sn2‐snar Reaction. Finally,In A Similar Process,Reaction Of This Same Bromide With Dimethyl Malonate Under Basic Conditions Gave 1,1‐bis(Methoxycarbonyl)‐6‐nitro‐1,2,3,4‐tetrahydronaphthalene In 80% Yield. Further Studies Exploring Ring Size Effects Are Also Presented.
Doi:10.1002/jhet.5570450239