CAS: 24517-64-4; 2-Amino-3-Cyanopyridine

相似化合物

13438-65-8 5345-47-1 7521-41-7

上下游产品

CAS号6602-54-6 2-氯烟腈 | CAS号51527-89-0 2-amino-pyridin... | CAS号17758-13-3 1-苯基嘧啶-2(1H)-酮 | CAS号109-77-3 丙二腈 | CAS号5345-47-1 2-氨基烟酸 | CAS号40306-97-6 Tetrazolo(1,5-a... | CAS号504-29-0 2-氨基吡啶 | CAS号112084-93-2 N-(3-cyano-2-py... | CAS号405224-24-0 5-溴-1H-吡唑并[3,4-... | CAS号405224-23-9 5-溴-2-氯烟腈 | CAS号144288-48-2 3-(氨基甲基)吡啶-2-胺 | CAS号504-29-0 2-氨基吡啶 | CAS号709652-82-4 2-氨基-5-溴-烟酰腈 | CAS号5345-47-1 2-氨基烟酸 | CAS号133427-07-3 咪唑并[1,2-A]吡啶-8-甲酸甲酯 | CAS号16081-87-1 2-phenyl-1H-pyr... | CAS号13438-65-8 2-氨基吡啶-3-甲酰胺

2-氨基烟酸置于diethylphosphoryl Cyanide,氯化铵,三乙胺体系中,用 乙二醇二甲醚,苯 用作溶剂,化学反应 2.0H,反应生成2-氨基-3-氰基吡啶
参考文献:Pyrido[2,3-D]Pyrimidine Derivatives: Synthesis Via The Intermolecular Aza-Wittig Reaction/heterocyclization And The Crystal Structure
标题:Pyrido[2,3-D]Pyrimidine Derivatives: Synthesis Via The Intermolecular Aza-Wittig Reaction/heterocyclization And The Crystal Structure
摘要:
Doi:10.1055/s-1998-2170

专利信息

专利号:WO-2009127773-A1
优先权日:2008-04-15
标 题:Method of using an electric field in the synthesis of materials
发明人：REIJONEN MIKA TAPIO
权利人:REIJONEN MIKA TAPIO
摘要:A synthesis method using polarization of materials by an electric field consists of two electrodes (1 and 4), an insulation layer (2), a dielectric layer (3) where the synthesis takes place, a voltage supply (5), a closed circuit and a synthesis container.

专利号:US-3950160-A
优先权日:1972-09-27
标题:Inhibiting the growth of weeds with 2-substituted pyrdidopyimidines and salts thereof
发明人：ABU EL-HAJ MARWAN J; DOMINY BERYL WILLIAM
权利人:PFIZER
摘要:2-Substituted pyridopyrimidines and their alkali and alkylamine salts as herbicides, and processes for the synthesis of starting materials leading to the preparation thereof.

专利号:US-2003069417-A1
优先权日:1999-04-19
标题:Novel synthesis and crystallization of piperazine ring-containing compounds
发明人：SINGER CLAUDE; LIBERMAN ANITA; FINKELSTEIN NINA
摘要:The present invention is directed to methods for the preparation of piperazine ring-containing compounds, particularly mirtazapine. According to the present invention, the mirtazapine intermediate 1-(3-carboxypyridyl-2)-4-methyl-2-phenyl-piperazine is made by hydrolyzing 1-(3-cyanopyridyl-2)-4-methyl-2-phenyl-piperazine with a base where the base is present in a ratio of up to about 12 moles of the base per one mole of 1-(3-cyanopyridyl-2)-4-methyl-2-phenyl-piperazine. The mirtazapine intermediate 1-(3-carboxypyridyl-2)-4-methyl-2-phenyl-piperazine may be made of hydrolyzing 1-(3-cyanopyridyl-2)-4-methyl-2-phenyl-piperazine with potassium hydroxide at a temperature of at least about 130° C. The method of the present invention also includes reacting 2-amino-3-hydroxymethyl pyridine with N-methyl-1-phenyl-2,2′-iminodiethyl chloride to form 1-(3-hydroxymethylpyridyl-2)-4-methyl-2-phenyl piperazine, and adding sulfuric acid to the 1-(3-hydroxymethylpyridyl-2)-phenyl-4-methylpiperazine to form mirtazapine. The present invention a recrystallization of mirtazapine from crude mirtazapine. The present invention also relates to crystalline adducts of mirtazapine and water, preferably containing up to about 3.5% by weight water, pharmaceutical compositions containing the crystalline adducts, and methods of treating depression by administering such compositions.

专利号:WO-0062782-A1
优先权日:1999-04-19
标题 :Novel synthesis and crystallization of piperazine ring-containing compounds
发明人：SINGER CLAUDE; LIBERMAN ANITA; FINKELSTEIN NINA
权利人:TEVA PHARMA; TEVA PHARMA; SINGER CLAUDE; LIBERMAN ANITA; FINKELSTEIN NINA
摘要:The present invention is directed to methods for the preparation of piperazine ring-containing compounds, particularly mirtazapine. According to the present invention, the mirtazapine intermediate 1-(3-carboxypyridyl-2)-4-methyl-2-phenyl-piperazine is made by hydrolyzing 1-(3-cyanopyridyl-2)-4-methyl-2-phenyl-piperazine with a base where the base is present in a ratio of up to about 12 moles of the base per one mole of 1-(3-cyanopyridyl-2)-4-methyl-2-phenyl-piperazine. The mirtazapine intermediate 1-(3-carboxypyridly-2)-4-methyl-2-phenyl-piperazine may be made by hydrolyzing 1-(3-cyanopyridyl-2)-4-methyl-2-phenyl-piperazine with potassium hydroxide at a temperature of at least about 130 °C. The method of the present invention also includes reacting 2-amino-3-hydroxymethyl pyridine with N-methyl-1-phenyl-2, 2'-iminodiethyl chloride to form 1-(3-hydroxymethylpyridyl-2)-4-methyl-2-phenyl piperazine, and adding sulfuric acid to the 1-(3-hydroxymethylpyridyl-2)-phenyl-4-methylpiperazine to form mirtazapine. The present invention also relates to new processes for recrystallization of mirtazapine form crude mirtazapine.

专利号:US-6576764-B2
优先权日:1999-04-19
标 题:Synthesis and crystallization of piperazine ring-containing compounds
发明人：SINGER CLAUDE; LIBERMAN ANITA; FINKELSTEIN NINA
权利人:TEVA PHARMA
摘要:The present invention is directed to methods for the preparation of piperazine ring-containing compounds, particularly mirtazapine. According to the present invention, the mirtazapine intermediate 1-(3-carboxypyridyl-2)-4-methyl-2-phenyl-piperazine is made by hydrolyzing 1-(3-cyanopyridyl-2)-4-methyl-2-phenyl-piperazine with a base where the base is present in a ratio of up to about 12 moles of the base per one mole of 1-(3-cyanopyridyl-2)-4-methyl-2-phenyl-piperazine. The mirtazapine intermediate 1-(3-carboxypyridyl-2)-4-methyl-2-phenyl-piperazine may be made by hydrolyzing 1-(3-cyanopyridyl-2)-4-methyl-2-phenyl-piperazine with potassium hydroxide at a temperature of at least about 130° C. The method of the present invention also includes reacting 2-amino-3-hydroxymethyl pyridine with N-methyl-1-phenyl-2,2'-iminodiethyl chloride to form 1-(3-hydroxymethylpyridyl-2)-4-methyl-2-phenyl piperazine, and adding sulfuric acid to the 1-(3-hydroxymethylpyridyl-2)-phenyl-4-methylpiperazine to form mirtazapine. The present invention also relates to new processes for recrystallization of mirtazapine from crude mirtazapine.

专利号:US-3962264-A
优先权日:1972-09-27
标 题:Process for making 2-amino nicotinonitrile
发明人：ABU EL-HAJ MARWAN J; DOMINY BERYL WILLIAM
权利人:PFIZER
摘要:2-Substituted pyridopyrimidines and their alkali and alkylamine salts as herbicides, and processes for the synthesis of starting materials leading to the preparation thereof.