CAS: 401-99-0; 3,5-Dinitrobenzotrifluoride

上下游产品

CAS号98-46-4 间硝基三氟甲苯 | CAS号393-75-9 4-氯-3,5-二硝基三氟甲苯 | CAS号454-73-9 3-氟-5-硝基三氟甲苯 | CAS号75-61-6 二溴二氟烷 | CAS号7664-93-9 硫酸 | CAS号7697-37-2 硝酸 | CAS号349-57-5 3-硝基-5-三氟甲基苯酚 | CAS号133532-73-7 1,1’-氧基双[3-硝基-5... | CAS号401-94-5 3-硝基-5-(三氟甲基)苯胺 | CAS号349-55-3 3-甲氧基-5-(三氟甲基)苯胺 | CAS号454-73-9 3-氟-5-硝基三氟甲苯 | CAS号454-67-1 3-氟-5-三氟甲基苯胺 | CAS号445-66-9 4-氨基-3,5-二硝基三氟甲苯 | CAS号368-53-6 3,5-二氨基三氟甲苯 | CAS号328-79-0 3-甲氧基-5-硝基三氟甲苯

4-氯-3,5-二硝基三氟甲苯置于溶剂黄146,Sodium Iodide体系中,用 丙酮 作为反应溶剂,化学反应 24.0H,以69%的收率获得产物3,5-二硝基三氟甲苯
参考文献:Khalfina; Rogozhnikova; Vlasov,Russian Journal Of Organic Chemistry,1996,Vol. 32,# 9,P. 1325-1331
标题:Khalfina; Rogozhnikova; Vlasov,Russian Journal Of Organic Chemistry,1996,Vol. 32,# 9,P. 1325-1331

专利信息

专利号:US-7709657-B2
优先权日:2005-06-09
标 题:Process for the synthesis of organic compounds
发明人：ACEMOGLU MURAT; SCHENKEL BERTHOLD; SHIEH WEN-CHUNG; XUE SONG; WIDMER ERICH; GARCIA FUENTES PEDRO; MARTIN MEDINA JOSE; VICENTE BANOS FRANCISCO
权利人:NOVARTIS AG
摘要:The present invention provides an efficient, safe and cost effective way to prepare 5-(4-methyl-1H-imidazol-1-yl)-3-(trifluoromethyl)-benzenamine which is an intermediate for the preparation of substituted pyrimidinylaminobenzamides of formula (II):

专利号:US-11414388-B2
优先权日:2018-04-10
标 题:Crystal form of 3-(4-methyl-1h-imidazol-1-yl)-5-trifluoromethylaniline monohydrochloride and use thereof
发明人：NIU DELIANG; MA BOJUN; ZHU ZHANQUN; WAN QIANG
权利人:ARIZEST SHANGHAI PHARMATECH CO LTD; JIANGSU XIDI PHARMACEUTICALS CO LTD; SHANGHAI ACEBRIGHT PHARMACEUTICALS GROUP CO LTD
摘要:The present invention relates to a crystal form of 3-(4-methyl-1H-imidazol-1-yl)-5-trifluoromethylaniline monohydrochloride and the use thereof. Specifically, disclosed are a crystal form A of a monohydrochloride anhydrous substance of 3-(4-methyl-1H-imidazol-1-yl)-5-trifluoromethylaniline monohydrochloride, a method for preparing the crystal form A and the use of the crystal form in the synthesis of nilotinib. The crystal form A of the present invention has good stability and purity, and can be directly used in the preparation and production of nilotinib. The method for preparing nilotinib in the present invention is easy to operate and has high industrial application value.

专利号:US-2008200691-A1
优先权日:2005-06-09
标题 :Process For the Synthesis of Organic Compounds

专利号:EP-1896425-B1
优先权日:2005-06-09
标 题 :Process for the synthesis of 5- (methyl- 1h-imidazol-1-yl) -3- (trifluoromethyl) -benzeneamine

专利号:WO-2006135619-A1
优先权日:2005-06-09
标 题 :Process for the synthesis of 5- (methyl- 1h-imidazol-1-yl) -3- (trifluoromethyl) -benzeneamine

专利号:CA-1256901-A
优先权日:1985-04-01
标题:Synthesis of bromethalin intermediate