CAS: 64169-67-1; 1-(4-Fluorophenyl)-1,3-Dihydroisobenzofuran-5-Carbonitrile

上下游产品

CAS号82104-74-3 5-氰基苯酞 | CAS号7439-95-4 镁标准溶液 | CAS号460-00-4 对氟溴苯 | CAS号64169-66-0 5-溴-1-(4-氟苯基)-酞内酯 | CAS号544-92-3 氰化亚铜 | CAS号445312-08-3 3-chloromethyl-... | CAS号335612-71-0 [1-(4-fluorophe... | CAS号207680-98-6 4-[(4-fluorophe... | CAS号335612-72-1 1-(4'-fluorophe... | CAS号335612-73-2 N-[[1-(4-fluoro... | CAS号59729-32-7 氢溴酸西酞普兰 | CAS号59729-33-8 西酞普兰 | CAS号62498-69-5 1-(3-aminopropy...

5-溴苯酞置于lithium Aluminium Tetrahydride,磷酸体系中,用 四氢呋喃,乙醚,N,N-二甲基甲酰胺 作为反应溶剂,化学反应 12.0H,反应生成 1-(4-氟苯基)-1,3-二氢异苯并呋喃-5-腈
参考文献:Reddy,M. Pulla; Bhujanga Rao; Usharani,Asian Journal Of Chemistry,2011,Vol. 23,# 4,P. 1829-1832
标题:Reddy,M. Pulla; Bhujanga Rao; Usharani,Asian Journal Of Chemistry,2011,Vol. 23,# 4,P. 1829-1832

专利信息

专利号:US-2008119662-A1
优先权日:2004-02-16
标 题:One Spot Synthesis of Citalopram from 5-Cyanophthalide
发明人：NARAHARI BABU AMBATI; SRINIVAS GOUD VUDDAMARI; GAONKAR SANTOSH LAXMAN; MANJUNATHA SULUR G; KULKARNI ASHOK KRISHNA; KULKARNI MADHARI A
权利人:JUBILANT ORGANOSYS LIMTED
摘要:A process for one pot synthesis of citalopram is disclosed. The process comprises subjecting 5-cyano phthalide to Grignard reduction followed cyclization and followed by C-alkylation reaction to obtain citalopram without isolation and purification of any intermediates. In another embodiment, 5-cyano phthalide is subjected to sequential Grignard reactions followed by cyclization to obtain citalopram without isolation and purification of any intermediate stages.

专利号:CA-2559703-A1
优先权日:2004-02-16
标 题:One pot synthesis of citalopram from 5-cyanophthalide

专利号:WO-03042202-A1
优先权日:2001-11-13
标 题 :Isobenzofuran derivatives
发明人：KUMAR YATENDRA; ARYAN RAM CHANDER; BHUSHAN KUMAR HARI
权利人:RANBAXY LAB LTD; KUMAR YATENDRA; ARYAN RAM CHANDER; BHUSHAN KUMAR HARI
摘要:The present invention relates to certain isobenzofuran derivatives and to a process for the synthesis of the same. The compounds of the present invention are analogs of a well known potent anti-depressant drug citalopram and hold promise to have anti-depressant activity. The invention also relates to pharmaceutical compositions containing the compounds of the present invention as potential anti-depressants.

专利号:WO-2005077927-A1
优先权日:2004-02-16
标 题:One pot synthesis of citalopram from 5-cyanophthalide

专利号:EP-1723133-A1
优先权日:2004-02-16
标 题:One pot synthesis of citalopram from 5-cyanophthalide

专利号:CH-692298-A5
优先权日:1999-10-25
标 题 :Process for the preparation of intermediates for citalopram synthesis and for the production of escitalopram.