专利号:US-8252783-B2 优先权日:2007-01-24 标 题:Quinolone carboxylic acids, derivatives thereof, and methods of making and using same 发明人:HARMS ARTHUR E; ARUL RAMAKRISHNAN; SONI ANIL K 权利人:HARMS ARTHUR E; ARUL RAMAKRISHNAN; SONI ANIL K; BAUSCH & LOMB 摘要:A process of preparing a quinolone carboxylic acid or its derivatives having Formula I, Ia, Ib, or IV, as shown herein, comprises using a starting quinolone that already has one or more desired substituents at one or more particular positions on the quinolone ring and preserving the orientation of such substituents throughout the synthesis. The present process comprises fewer steps than prior-art processes. The present process also can include a simple separation of a desired enantiomer of the quinolone carboxylic acid or its derivatives from the enantiomeric mixture. Pharmaceutical compositions comprising fluoroquinolones prepared by the present process can be used effectively against a variety of microbial pathogens.
专利号:CN-113150064-A 优先权日:2021-04-14 标题 :A kind of artificial synthesis method of antibacterial and anti-insect peptide and its application
专利号:CN-113150064-B 优先权日:2021-04-14 标题:A kind of artificial synthesis method and application of antibacterial and insect-resistant peptide
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合成参考文献
摘要:Archives of Biochemistry and Biophysics., 64(319), 1956 []