专利号:US-7674876-B2 优先权日:2005-05-25 标题:Synthesis of novel monomers containing the trifluorovinylidene group and the cyanato group and polymers thereof 发明人:DREYER CHRISTIAN; BAUER MONIKA; IYER SURESH S; SMITH DENNIS W 权利人:FRAUNHOFER GES FORSCHUNG; UNIV CLEMSON 摘要:Novel hybrid monomers containing both the aryltrifluorovyinyloxyether-group (TFVE-group) and the cyanato-group, their synthesis, and the synthesis of polymers made from these new hybrid monomers are disclosed.
专利号:US-5914431-A 优先权日:1996-09-23 标 题 :Cocatalysts for the synthesis of bisphenols 发明人:FENNHOFF GERHARD 权利人:BAYER AG 摘要:The invention relates to the synthesis of bisphenols from monophenols and carbonyl compounds such as aldehydes and ketones using concentrated mineral acids such as hydrochloric acid and/or hydrogen chloride gas as acid catalysts and a mercaptan as cocatalyst, which is fixed by an ion pair bond to a matrix that is insoluble in the reaction medium.
专利号:US-5698600-A 优先权日:1995-10-24 标题:Process for the production of bisphenols with the use of new cocatalysts 发明人:WULFF CLAUS; FENNHOFF GERHARD; EITEL ALFRED 权利人:BAYER AG 摘要:The invention relates to the synthesis of bisphenols from monophenols and carbonyl compounds such as aldehydes and ketones with concentrated mineral acids such as hydrochloric acid and/or hydrogen chloride gas as acid catalysts and a mercaptan as cocatalyst, which is fixed by an ion-pair bond to a matrix insoluble in the reaction medium.
专利号:US-2005080260-A1 优先权日:2003-04-22 标 题 :Preparation of prodrugs for selective drug delivery 发明人:MILLS RANDELL L; WU GUO-ZHANG 摘要:Synthesis of a chemical compound having the formula A-B-C that may serve for applications such as drug delivery where A is a chemiluminescent, moiety, B is a photochromic moiety, and C is a biologically active moiety where A-B-C may serve as a prodrug. Novel synthetic methods of the present invention to form the prodrug comprised the steps of (1) forming a benzophenone, (2) forming a diaryl ethylene, (3) attaching a phthalimide moiety to at least one of the aryl groups of the ethylene to form a phthalimide-ethylene conjugate, (4) condensing two ethylene-phthalimide conjugates to form a phthalimide-pentadiene conjugate, (5) converting the phthalimide to the phthalhydrazide by reaction with hydrazine to form a carrier compound according to the present invention, and (6) reacting the carrier compound with an nucleophilic moiety of the drug to form the corresponding prodrug. Alternatively the carrier can be prepared by using the halo-substituted diaryl ethylene to make the corresponding cationic leuco dye-like compound with known methods. The cationic compound then is protected by reacting with a nucleophile and coupled with the aminophathalimide by palladium-catalyzed amination to form the protected phthalimide-pentadiene conjugate. The latter is refluxed with hydrazine to convert its phthalimide to the phthalhydrazide and acidified to give the carrier. An additional aspect of the present invention relates to the use of these compounds as antiviral agents for the treatment of viral infections such as HIV and as anticancer agents for the treatment of cancers such as bowel, lung, and breast cancer.
专利号:EP-0377198-A2 优先权日:1988-12-31 标题:Chloroformiates of aromatic ketones, and process for their preparation 发明人:BOETTCHER ANDREAS DR; HENKELMANN JOCHEM DR 权利人:BASF AG 摘要:The invention relates to chloroformates of aromatic ketones and their preparation from aromatic hydroxyketones by phosgenation in the presence of acidic catalysts.n n n The chloroformates according to the invention are intermediates for the synthesis of organic compounds.
专利号:US-2001046938-A1 优先权日:2000-03-04 标 题:Synthesis of dilithium initiator