CAS: 13466-43-8; 3-Bromopyridin-2(1H)-One

相似化合物

18368-59-7 848423-85-8 137628-16-1

上下游产品

CAS号142-08-5 2-羟基吡啶 | CAS号98976-68-2 pyridin-2-yl N,... | CAS号30236-48-7 3-thiophen-2-yl... | CAS号24228-13-5 2-羟基-3-苯基吡啶 | CAS号30236-47-6 3-(furan-2-yl)-... | CAS号52200-48-3 3-溴-2-氯吡啶 | CAS号52200-49-4 2-苄氧基-3-溴吡啶 | CAS号13472-59-8 2-甲氧基-3-溴吡啶 | CAS号342602-27-1 3-溴-5-二氟甲氧基吡啶 | CAS号13466-35-8 3-氯-2-羟基吡啶 | CAS号81971-38-2 3-溴-1-甲基-2-吡啶酮 | CAS号951655-49-5 1,2-二氢-2-氧代-吡啶-3-基硼酸

3,5-二溴-2-羟基嘧啶置于仲丁基锂,水体系中,用71%的收率获得3-溴-2-羟基吡啶
参考文献:Efficient Regioselective Preparationof Monobromo And Bromoiodo Hydroxy Pyridines From Dibromoderivativesvia Bromine-Lithium Exchange
标题:Efficient Regioselective Preparationof Monobromo And Bromoiodo Hydroxy Pyridines From Dibromoderivativesvia Bromine-Lithium Exchange
摘要:氢氧嘧啶的环状二溴化反应采用nbs在乙腈中进行,随后与rli进行溴锂交换,最后用h2O或i2捕获,完全区域选择性地得到了单溴和溴碘衍生物.用nis对溴氢氧嘧啶进行碘化反应也是完全区域选择性的.
Doi:10.1055/s-2003-41013

专利信息

专利号:US-6376676-B1
优先权日:1993-06-30
标题 :Intermediates in the synthesis of (±)-camptothecin and related compounds and synthesis thereof
发明人：CURRAN DENNIS P; LIU HUI
权利人:UNIV PITTSBURGH
摘要:The present invention provides a short, convergent total synthesis of novel intermediates in the synthesis of (±)-camptothecin and related compounds. The present synthesis scheme includes a novel 4+1 radical annulation followed by another cyclization to simultaneously assemble rings B and C of the camptothecin compound. The present invention also provides novel chemical intermediates for such 4+1 radical annulations.

专利号:US-6252079-B1
优先权日:1993-06-30
标 题 :Intermediates in the synthesis of camptothecin and related compounds and synthesis thereof
发明人：CURRAN DENNIS P; BOM DAVID
权利人:UNIV PITTSBURGH
摘要:The present invention provides a short, convergent total synthesis of irinotecan and derivative compounds which comprises of a novel 4+1 radical annulation wherein the precursoris reacted with an aryl isonitrile having the formulawherein X is Br or I, and R4 is an alkyl group, an allyl group, a propargyl group or a benzyl group, and R16 is H, a C1-C6 alkoxy group, agroup wherein p is an integer between 4 and 12, or a C1-C12 acyclic dialkylamino group. The present invention also provides novel chemical intermediates for such 4+1 radical annulations.

专利号:US-6982333-B2
优先权日:1993-06-30
标 题:Intermediates in the synthesis of camptothecin and related compounds and synthesis thereof
发明人：CURRAN DENNIS P; JOSIEN HUBERT; KO SUNG BO
权利人:UNIV PITTSBURGH
摘要:The present invention provides a short, convergent total synthesis of camptothecin and related compounds which consists of a novel 4+1 radical annulation. The present invention also provides novel chemical intermediates for such 4+1 radical annulations.

专利号:WO-03099825-A1
优先权日:2002-05-22
标题 :Synthesis of polycyclic quinolines
发明人：CURRAN DENNIS P; DU WU
权利人:UNIV PITTSBURGH; CURRAN DENNIS P; DU WU
摘要:A method of synthesizing a polycyclie quinoline comprising the step of a cascade annulation wherein the precursor is reacted with an aryl isonitrile having the formula in the presence of a transition metalwherein X is chlorine, bromine, iodine or triflate; wherein R1, R2, R3 and R4 are independently the same or different and are hydrogen, -OR wherein R is H, an alkyl group, an aryl goup or a hydroxy protecting group, an alkyl group, an aryl group, an alkenyl group, an alkynyl group, an acyloxy group, an acylamino group, a nitro group, a cyano group, -OC(O)ORa, wherein Ra is an alkyl group or an aryl group, -NRbRC wherein Rb and Rc are independently the same or different, H, an alkyl group, an aryl group or an amino protecting group, -OC(O)NRbRC, -C(O)Rd wherein Rd is H, an alkyl group, an aryl group, an alkoxy group, or -NRbRC, -SR, wherein Re is an alkyl group or an aryl group, -OSiRe3, or R1 and R2 or R2 and R3 together form a chain of three or four members selected from the group of CH, CH2, O, S, NH, of NRf, wherein Rf is an C1-C6 alkyl group; wherein R5 is cyano, an alkyl group, an aryl group, an alkenyl group, an alkynyl group, -C(O)Rd wherein Rd is H, an alkyl group, an aryl group, an alkoxy group, -NRb RC, or -Si(RgRhRi)..or -(Rj)Si(RgRhRi), wherein Rj is an alkylene group, an alkenylene group, or an alkynylene group; and R6, Rh and Ri are independently a C1-10 alkyl group, a C2-10 alkenyl group, a C2-10 alkynyl group, or an aryl group; wherein R6 is H, F, Cl, a C1-3 alkyl group, a C2-3 alkenyl group, a C2-3 alkynyl group, a trialkylsilyl group or a C1-3 alkoxy group; and wherein R7 and R8 are independently the same or different and are H, F, Cl, an alkyl group, an aryl group, a hydroxyalkyl group, a dialkylamino alkyl group, or wherein R7 and R8 together form a chain of four or five members selected from the groups -C(Rk)(OR1)(CH2)ZC(O)OCH2- wherein z is an integer between 0 and 1, wherein Rk is H, an alkyl group, an allyl group, a propargyl group or a benzyl group, Rl is H, -C(O)Rd wherein Rd is H, an alkyl group, an aryl group, an alkoxy group, -NRbRc or -Si(RmRnRo) wherein Rm, Rn and Ro are independently a C1-10 alkyl group, a C2-10 alkenyl group, a C2-10 alkynyl group, or an aryl group..

专利号:US-2004063947-A1
优先权日:1993-06-30
标 题:Novel intermediates in the synthesis of camptothecin and related compounds and synthesis thereof

专利号:US-6211371-B1
优先权日:1993-06-30
标 题:Intermediates in the synthesis of camptothecin and related compounds and synthesis thereof