CAS: 2905-21-7; 2-Fluorobenzene-1-Sulfonyl Chloride

上下游产品

CAS号348-54-9 邻氟苯胺 | CAS号180905-88-8 N-cyclopropyl-1... | CAS号180905-86-6 1-(2-fluorophen... | CAS号180905-85-5 ethyl 1-(2-fluo... | CAS号30058-40-3 2-氟苯磺酰胺 | CAS号530116-14-4 1-(2-fluorophen... | CAS号52200-99-4 2-氟苯磺酰氟

2-氟苯硫酚置于硝酸铵,盐酸,氧气体系中,用 水,乙腈 用作溶剂,化学反应 2.0H,以75%的收率获得2-氟苯磺酰氯
参考文献:在好氧和无金属条件下将硫醇转化为磺酰卤
标题:在好氧和无金属条件下将硫醇转化为磺酰卤
摘要:开发了在硝酸铵,Hcl和hbr的水溶液以及氧气作为末端氧化剂的情况下,由硫醇对环境无害,无金属的磺酰氯和溴化物的合成方法.检查了各种取代的硫酚,苄基,脂族和杂芳族硫醇的反应性.硝酸铵用作氮氧化物(no / No 2),它们是氧化还原催化循环中的关键参与者.无需萃取即可分离出磺酰氯和溴化物,并在短硅胶垫上"过滤".与传统的分离和纯化方法相比,大大减少了溶剂的使用.还展示了用于将硫醇转化为磺酰胺的"一锅法"方案.显示了制备磺酰氯和溴化物的放大实验.讨论了可能的反应途径.
Doi:10.1039/c7Gc00556C

专利信息

专利号:UA-47128-U
优先权日:2009-11-10
标 题:METHOD FOR SYNTHESIS OF ISOMERS OF FLUORNITROBENZENESULFONYL CHLORIDE

专利号:US-9868746-B2
优先权日:2012-02-23
标题:Substituted 5-aminothieno[2,3-C]pyridazine-6-carboxamide analogs as positive allosteric modulators of the muscarinic acetylcholine receptor M4
发明人：LINDSLEY CRAIG W; CONN P JEFFREY; WOOD MICHAEL R; MELANCON BRUCE J; TARR JAMES C; SALOVICH JAMES M; POSLUSNEY MICHAEL S
权利人:UNIV VANDERBILT
摘要:In one aspect, the invention relates to substituted 5-aminothieno[2,3-c]pyridazine-6-carboxamide analogs, derivatives thereof, and related compounds, which are useful as positive allosteric modulators of the muscarinic acetylcholine receptor M 4 (mAChR M 4 ); synthesis methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating neurological and psychiatric disorders associated with muscarinic acetylcholine receptor dysfunction using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

专利号:CN-117720498-A
优先权日:2023-11-03
标 题 :Synthesis of a new coumarin derivative containing a sulfonamide fragment and preparation method and application of its composition

专利号:CN-119320374-A
优先权日:2024-11-04
标 题 :A method for photocatalytic synthesis of 3-sulfonyl-substituted chromone derivatives

专利号:PT-735023-E
优先权日:1995-03-24
标 题 :REAGENT AND PROCESS FOR THE SYNTHESIS OF SULFOXILATED AND FLUORINATED ORGANIC DERIVATIVES

专利号:CN-104540803-B
优先权日:2012-08-13
标题 :Synthesis intermediate of 1- (2-deoxy-2-fluoro-4-thio- β -D-arabinofuranosyl) cytosine, synthesis intermediate of thionucleoside, and processes for producing these