CAS: 43119-28-4; (3Ar,6As)-3,3A,6,6A-Tetrahydro-2H-Cyclopenta[b]Furan-2-One

专利信息

专利号:US-4140708-A
优先权日:1975-10-16
标 题 :Asymmetric synthesis of optically active prostaglandins
发明人：CHADHA NARESH K; PARTRIDGE JR JOHN J; USKOKOVIC MILAN R
权利人:HOFFMANN LA ROCHE
摘要:An asymmetric synthesis of optically active prostaglandin F 2 α from cyclopentadiene including intermediates in this synthesis.

专利号:US-3933892-A
优先权日:1973-02-12
标题 :Asymmetric synthesis of optically active prostaglandins
发明人：CHADHA NARESH KUMAR; PARTRIDGE JR JOHN JOSEPH; USKOKOVIC MILAN RADOJE
权利人:HOFFMANN LA ROCHE
摘要:An asymmetric synthesis of optically active prostaglandin F 2 .sub.α from cyclopentadiene including intermediates in this synthesis.

专利号:US-2004147775-A1
优先权日:2002-12-23
标 题:Process for the synthesis of 3.3A.6.6A-tetrahydro-2H-cyclopentan[b]furan-2-one
发明人：HENEGAR KEVIN EDWARD; CEBULA MATEUSZ
摘要:The present invention relates to a process for the synthesis of 3,3a,6,6a-tetrahydo-2H-cyclopentan[b]furan-2-one.

专利号:US-4204999-A
优先权日:1976-02-20
标题:Process for making bicyclic lactone derivatives for use as intermediates in the synthesis of prostaglandins
发明人：KERESZTES NEE ORDOG BORBALA; KOVACS GABOR; LOVASZ NEE GASPAR MARIANNA; REMPORT NEE RADOCZI JULIA; SIMONIDESZ VILMOS; STADLER ISTVAN; SZANTAY CSABA; SZEKELY ISTVAN; TOMOSKOZI ISTVAN; VISKY NEE GOMBOS ZSUZSA
权利人:CHINOIN GYOGYSZER ES VEGYESZET
摘要:A process for the preparation of optically active or racemic lactone diol derivatives of the formula (for use as intermediates in the Corey prostaglandin synthesis). Optically active or racemic lactone diol derivatives are inclosed, in which R3 and R4 are the same or different and stand for a hydrogen, or a lower alkanoyl optionally substituted with one, two or three halogen atoms, or form together a group, in which R5 and R6 are the same or different and stand for a hydrogen, alkyl or aryl, with a process for preparing them. According to the invention the above compound are prepared by reacting optically active or racemic lactone of the formula II with formaldehyde or with a formaldehyde polymerisate, in the presence of the mixture of a strong acid and water or of a lower alkane carboxylic acid optionally substituted with one, two or three halogen atoms, and then optionally subjecting the obtained compound of the general formula I, in which R3 and/or R4 stand for an alkanoyl optionally substituted with one, two or three halogen atoms to partial or total hydrolysis or alcoholysis in an acid or alkaline medium and/or reacting it with the oxo-compounds of the formula R5-CHO or R6-CO-R5 or with the acetals of the above compounds. The compounds according to the invention are useful intermediates in the Corey prostaglandine synthesis.

专利号:US-4126622-A
优先权日:1976-02-20
标题:Bicyclic lactone derivatives employed as intermediates in the synthesis of prostaglandines
发明人：TOMOSKOZI ISTVAN; KOVACS GABOR; SZEKELY ISTVAN; SIMONIDESZ VILMOS; LOVASZ NEE GASPAR MARIANNA; KERESZTES NEE ORDOG BORBALA; REMPORT NEE RADOCZI JULIA; STADLER ISTVAN; VISKY NEE GOMBOS ZSUZSA; SZANTAY CSABA
权利人:CHINOIN GYOGYSZER ES VEGYESZET
摘要:A compound of the formula is disclosed. ##STR1## wherein R 3 and R 4 are the same or different and are each hydrogen, lower alkanoyl, lower alkanoyl substituted by 1, 2, or 3 halogen atoms, or R 3 and R 4 together form an ##STR2## group in which R 5 and R 6 are the same or different and are each hydrogen, alkyl or aryl as well as a process for the preparation thereof.

专利号:EP-1581479-A1
优先权日:2002-12-23
标题:Process for the synthesis of 3,3a,6,6a-tetrahydro-2h-cyclopentan[b]furan-2-one