专利号:US-2008171873-A1 优先权日:2007-01-12 标题:Synthesis of selected stereoisomers of certain substituted alcohols 发明人:HARMS ARTHUR E 权利人:HARMS ARTHUR E 摘要:A process for producing one selected stereoisomer of a substituted alcohol comprises reacting a stereoisomeric amine with a halogen-substituted heterocyclic compound, or a stereoisomeric ketone or aldehyde with an amino-substituted heterocyclic compound. The process avoids the production of a racemic mixture of stereoisomers of the prior art. Such a stereoisomeric substituted alcohol can be used for anti-inflammatory therapy.
专利号:US-2011137038-A1 优先权日:2006-11-09 标题 :Synthesis of selected stereoisomers of certain substituted alcohols 发明人:HARMS ARTHUR E 权利人:HARMS ARTHUR E 摘要:A process for producing one selected stereoisomer of a substituted alcohol comprises reacting a stereoisomeric epoxide with an amine, a carboxylic acid, an amide, a sulfonyl, or a cyanide. The process avoids the production of a racemic mixture of stereoisomers of the prior art. Such a stereoisomeric substituted alcohol can be used for anti-inflammatory therapy.
专利号:WO-2008088969-A2 优先权日:2007-01-12 标 题 :Synthesis of selected stereoisomers of certain substituted alcohols
专利号:US-RE41614-E 优先权日:1998-09-30 标题 :Synthetic analogs of ecteinascidin-743 发明人:COREY ELIAS J 权利人:HARVARD COLLEGE 摘要:The present invention is directed to the synthesis and characterization of compounds having the formula: n n wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 and R 9 are each independently selected from the group consisting of H, OH, OR′, SH, SR′, SOR′, SO 2 R′, NO 2 , NH 2 , NHR′, N(R′) 2 , NHC(â•?O)R′ NHC( â•?O ) R′ , CN, halogen, â•?O, C(â•?O)H, C(â•?O)R′, CO 2 H, CO 2 R′, C 1 -C 12 alkyl, C 2 -C 12 alkenyl, C 2 -C 12 alkynyl, substituted or unsubstituted aryl, substituted or unsubstituted aralkyl, and substituted or unsubstituted heteroaromatic; wherein each of the R′ groups is independently selected from the group consisting of H, OH, NH 2 , NO 2 , SH, CN, halogen, â•?O, C(â•?O)H, C(â•?O)CH 3 , CO 2 H, CO 2 CH 3 , C 1 -C 12 alkyl, C 2 -C 12 alkenyl, C 2 -C 12 alkynyl, aryl, aralkyl, and heteroaromatic; wherein each dotted circle represents one, two or three optional double bonds; wherein R 7 and R 8 may be are joined into a carbocyclic or heterocyclic ring system; and wherein X 1 and X 2 are each independently defined as above for R 1 -R 8 R 1 - R 6 and R 9 , an each further includes specific preferred groups as defined herein.
专利号:AU-2007319590-A1 优先权日:2006-11-09 标 题 :Synthesis of selected stereoisomers of certain substituted alcohols
专利号:US-2008114172-A1 优先权日:2006-11-09 标 题 :Synthesis of Selected Stereoisomers of Certain Substituted Alcohols