CAS: 474-58-8; (2R,3R,4S,5S,6R)-2-(((3S,8S,9S,10R,13R,14S,17R)-17-((2R,5R)-5-Ethyl-6-Methylheptan-2-yl)-10,13-Dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-Tetradecahydro-1H-Cyclopenta[a]Phenanthren-3-yl)Oxy)-6-(Hydroxymethyl)Tetrahydro-2H-Pyran-3,4,5-Triol

结构式图片

上下游产品

CAS号137909-13-8 3-[(2,3,4,6-tet... | CAS号83-46-5 β-谷甾醇 | CAS号572-09-8 2,3,4,6-四乙酰氧基-a... | CAS号4291-69-4 2,3,4,6-四邻苄基-al... | CAS号74808-09-6 2,3,4,6-四-O-苄基-... | CAS号53657-29-7 sitoindoside II | CAS号18749-71-8 Sitoindoside I | CAS号18749-71-8 Sitoindoside I | CAS号83-46-5 β-谷甾醇 | CAS号2280-44-6 D-glucopyranose | CAS号50-99-7 D(+)-无水葡萄糖 | CAS号1139-97-5 2,3,4,6-tetra-O...

合成工艺路线路线简述

  • 合成目标产物 Eleutheroside A 主要起始原料 D-Glucose And Beta-Sitosterol
  • (文献来源)合成步骤主要原料 D-Glucose 和 Beta-Sitosterol
豆甾醇置于三氟化硼乙醚,Lithium体系中,用 四氢呋喃,二氯甲烷,氨 作为反应溶剂,化学反应 3.5H,反应生成 西托糖苷
参考文献:来自 Edgeworthia Chrysantha 的杀鱼甾醇酰基葡萄糖苷
标题:来自 Edgeworthia Chrysantha 的杀鱼甾醇酰基葡萄糖苷
摘要:关键词索引-Edgeworthio Chrysantha; 百里香科;花,谷甾醇-3-O--亚麻醇-基-和谷甾醇-3-O-64Inolenoyl-8-吡喃葡萄糖苷;蚂蚱酮;瑞香素;鱼尾活动;菊花苷的合成.摘要-从 E~geworr~ju C~ysunr~a 的花中获得了名为 Chrysanthosides 的新型强效杀鱼甾醇酰基葡萄糖苷,以及先前已知的双香豆素和蚱蜢酮及其结构特征为谷甾醇-3-O-6-Linoleoyl-和sitosterol-3-O-6-Linolenoyl-~-~giupyranos~des 通过光谱数据和合成.天然和合成的菊花苷对在 0.1 Ppm 浓度下在 3 小时内被杀死的死鱼具有强效的杀鱼活性.introdl'Ciion E~gewort~ia C~~ysun~~u (= E. Pupy~~ra) 已被用于制造优质纸张,尽管它产生具有强促肿瘤活性的达芬烷型二萜类化合物
DOI:10.1016/s0031-9422(00)98226-8

专利信息


专利号:WO-2011011384-A9
优先权日:2009-07-20
标 题 :Synthesis of dendrimer conjugates

专利号:EP-1493431-B1
优先权日:2003-07-03
标题:Use of an extract of bauhinia for the preparation of pharmaceutical and cosmetic compositions
发明人:WIRTH CORINNA DR; BUCHHOLZ HERWIG DR
权利人:MERCK PATENT GMBH
摘要:Use of an aqueous or aqueous-alcoholic extract (A) of Bauhinia is claimed to make a composition for cosmetic or pharmaceutical treatment of skin and hair. Use of an aqueous or aqueous-alcoholic extract (A) of Bauhinia is claimed to make a composition for: (a) care, preservation or improvement of the general condition of the skin or hair; (b) prevention and/or inhibition of the aging process for human skin or hair; (c) for promoting healing of wounds; (d) for prevention and/or treatment of skin diseases associated with abnormal keratinization, and (e) for prevention and/or treatment of all malignant or benign growths of the dermis or epidermis. An independent claim is also included for a composition containing (A). ACTIVITY : Dermatological; Vulnerary; Antiseborrheic; Antipsoriatic; Cytostatic; Antiinflammatory; Virucide. MECHANISM OF ACTION : Protein glycosylation inhibitor. In a test, human fibroblasts were cultured in the presence of Vitamin C to stimulate collagen synthesis, then lysed and labeled with tritiated glucose for 15 days, Proteins were removed, extraction and precipitation were carried and the amount of bound glucose measured by liquid scintillation counting. Addition of an aqueous-alcoholic extract of Bauhinia fortificata (0.03 mg/ml), reduced protein glycosylation to 55% of that in a control.

专利号:US-2022288181-A1
优先权日:2021-03-12
标 题 :Antiviral vaccines using spherical nucleic acids
发明人:MIRKIN CHAD A; TEPLENSKY MICHELLE HOPE; DISTLER MAX EVERETT; KUSMIERZ CAROLINE DANIELLE; CALLMANN CASSANDRA ELIZABETH
权利人:UNIV NORTHWESTERN
摘要:Spherical Nucleic Acids (SNAs) are chemically well-defined nanoscale architectures comprised of nucleic acids densely arranged around a spherical nanoparticle core in a highly oriented fashion. SNAs are highly modular structures produced by chemical synthesis and programmed assembly, allowing for their rapid modification to incorporate novel viral antigens. The present disclosure provides a SNA comprising (a) a nanoparticle core; (b) a shell of oligonucleotides attached to the external surface of the nanoparticle core, the shell of oligonucleotides comprising one or more immunostimulatory oligonucleotides; and (c) a viral antigen encapsulated in the nanoparticle core.

专利号:WO-2011059609-A9
优先权日:2009-10-13
标 题 :Dendrimer compositions and methods of synthesis

专利号:WO-2011028334-A2
优先权日:2009-08-26
标题:Synthesis and isolation of dendrimer systems

专利号:US-9700589-B2
优先权日:2015-02-03
标题:Compositions and methods for improved muscle metabolism
发明人:BILY ANTOINE CHARLES; MEYER MARJOLAINE; CHEVALIER KARL; Laurençon Lise; FEUILLERE NICOLAS; ROLLER MARC; BIRTIC SIMONA
权利人:NATUREX SA
摘要:A composition for improving muscle metabolism in a subject and methods for manufacturing and using same. Embodiments include compositions having an extract of Rhaponticum and an extract of Rhodiola . An extract of Rhaponticum may include amounts of ecdysterones including 20-hydroxyecdysone. An extract of Rhodiola my include salidrosides and rosavins, including rosavin. Suitable ingestion dosages of the composition may be operable to increase protein synthesis and reduce protein proteolysis in a subject.
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主要参考文献


1: Arief I, Sunnardianto GK, Khairi S, Saputri WD. The potential of Mitragyna speciosa leaves as a natural source of antioxidants for disease prevention. J Integr Bioinform. 2024 Sep 17. doi: 10.1515/jib-2023-0030. Epub ahead of print. 24(1):495. doi: 10.1186/s12879-024-09387-w.
3: Li T, Li W, Guo X, Tan T, Xiang C, Ouyang Z. Unraveling the potential mechanisms of the anti-osteoporotic effects of the Achyranthes bidentata- Dipsacus asper herb pair: a network pharmacology and experimental study. Front Pharmacol. 2023 Oct 2;14:1242194. doi: 10.3389/fphar.2023.1242194.
4: Liu C, Liu Y, Liu Y, Guan J, Gao Y, Ou L, Qi Y, Lv X, Zhang J. Network Pharmacology, Molecular Docking and Experimental Verification Revealing the Mechanism of Fule Cream against Childhood Atopic Dermatitis. Curr Comput Aided Drug Des. 2024;20(6):860-875. doi: 10.2174/0115734099257922230925074407. 27(8):3681-3698. doi: 10.26355/eurrev_202304_32165. 41(24):15085-15105. doi: 10.1080/07391102.2023.2186720. Epub 2023 Mar 8.

合成参考文献


参考文献:10.1021/np010042g
摘要:Zhang Z, ElSohly HN, Jacob MR, Pasco DS, Walker LA, Clark AM. New Indole Alkaloids from the Bark of Nauclea orientalis. J. Nat. Prod. 2001 Jul 13;64(8):1001–5. doi: 10.1021/np010042g.
参考文献:10.1248/cpb.44.492
摘要:Yoshikawa M, Yoshizumi S, Murakami T, Matsuda H, Yamahara J, Murakami N. Medicinal foodstuffs. II. On the bioactive constituents of the tuber of Sagittaria trifolia L. (Kuwai, Alismataceae): absolute stereostructures of trifoliones A, B, C, and D, sagittariosides a and b, and arabinothalictoside. Chem Pharm Bull (Tokyo). 1996 Mar;44(3):492–9. doi: 10.1248/cpb.44.492.
参考文献:10.1248/cpb.47.375
摘要:Wu TS, Kao MS, Wu PL, Lin FW, Shi LS, Liou MJ, Li CY. The bakkenolides from the root of Petasites formosanus and their cytotoxicity. Chem Pharm Bull (Tokyo). 1999 Mar;47(3):375–82. doi: 10.1248/cpb.47.375.
参考文献:10.1016/s0031-9422(01)00180-7
摘要:Gu JQ, Park EJ, Luyengi L, Hawthorne ME, Mehta RG, Farnsworth NR, Pezzuto JM, Kinghorn AD. Constituents of Eugenia sandwicensis with potential cancer chemopreventive activity. Phytochemistry. 2001 Sep;58(1):121–7. doi: 10.1016/s0031-9422(01)00180-7.
参考文献:10.1248/yakushi.122.291
摘要:Isobe T, Ohsaki A, Nagata K. [Antibacterial constituents against Helicobacter pylori of Brazilian medicinal plant, Pariparoba]. Yakugaku Zasshi. 2002 Apr;122(4):291–4. doi: 10.1248/yakushi.122.291.
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