CAS: 57526-28-0; Dl-2-Methylbutyryl Chloride

上下游产品

2-Methylbutanoic acid benzoyl chloride (2)1.1.3-Trichlor-butadien-(1.3)-carbonsaeure-(2) Tiglic acid1-chloro-3-methyl-pentan-2-one 2-methyl-1-(2,4,6-trihydroxyphenyl)-1-butanone butyryl-(2-methyl-butyryl)-amine 2-ethyl-2-methylmalonic acid

2-甲基丁酸置于氯化亚砜,N,N-二甲基甲酰胺体系中,化学反应 2.0H,以85%的收率获得产物2-甲基丁酰氯
参考文献:Baker-Venkataraman重排全合成rac-γ-吲哚霉素酮
标题:Baker-Venkataraman重排全合成rac-γ-吲哚霉素酮
摘要:外消旋 γ-吲哚霉素 (Rac-3) 的全合成是通过将酯 11 重排为二酮 12,酸催化环化为蒽酮 13,然后甲基醚裂解和乙酰化为 16,选择性溴化支链侧链同时 Sn1 型羟基取代为 23,酯交换为 Rac-3.相应的 γ-吲哚霉素 11-甲基醚 (Rac-20) 以类似的反应顺序制备. (© Wiley-Vch Verlag Gmbh & Co. Kgaa,69451 Weinheim,Germany,2007)
DOI:10.1002/ejoc.200700015

专利信息

专利号:US-2007015798-A1
优先权日:2005-02-25
标 题 :Efficient and stereoselective process for large scale synthesis of (3R)-3-(2,3-dihydrobenzofuran-5-yl)-1,2,3,4-tetrahydropyrrolo[3,4-b]quinolin-9-one derivatives
发明人：LI XUN; LEMAIRE SEBASTIEN; MARKO ISTVAN; WILLEMSENS ALBERT
权利人:LI XUN; LEMAIRE SEBASTIEN; MARKO ISTVAN; WILLEMSENS ALBERT
摘要:This invention relates to an efficient process for large scale stereoselective production of (3R)-3-(2,3-dihydrobenzofuran-5-yl)-1,2,3,4-tetrahydropyrrolo[3,4-b]quinolin-9-ones and key intermediates used for the preparation of benzofuranyl pyrroloquinolones as potent and selective PDE5 inhibitors for the treatment of erectile dysfunction, as well as pharmaceutical compositions and methods of treatment utilizing these compounds.

专利号:US-10947189-B2
优先权日:2017-08-12
标 题:Online continuous flow process for the synthesis of organic peroxides using hydrogen peroxide as raw material
发明人：MA BING; PAN SHUAI; SHU XINLIN
权利人:SHANGHAI HYBRID CHEM TECH
摘要:An online continuous flow production process for directly preparing organic peroxides by using hydrogen peroxide as a raw material. This production process uses hydrogen peroxide, catalyst, and an oxidation substrate as a raw material. Substrate will be turned to designated peroxides sequentially through oxidation and workup. This process is performed in a plug-and-produce integrated continuous flow reactor, and the raw materials are continuously fed to the reactor. So, specified peroxide can be continuously obtained at the outlet of the plug-and-produce integrated continuous flow reactor.

专利号:US-2020172478-A1
优先权日:2017-08-12
标题 :Online continuous flow process for the synthesis of organic peroxides using hydrogen peroxide as raw material

专利号:US-2025162973-A1
优先权日:2022-02-22
标题:Methods of synthesis and uses of agrimol compounds
发明人：CHE CHI MING; FU ZHIWEN; LEUNG YIU CHUNG GULICE
权利人:VERSITECH LTD; LABORATORY FOR SYNTHETIC CHEMISTRY AND CHEMICAL BIOLOGY LTD
摘要:Synthetic agrimol B and derivatives thereof (“compoundsâ€?) that have anticancer properties are disclosed. Methods for synthesizing the compounds with an overall yield ≥7% are disclosed. Pharmaceutical formulations in forms suitable for the delivery of the compounds to a subject in need thereof are disclosed. Methods of using the compounds for treating a cancer, reducing a cancer, or treating or ameliorating one or more symptoms associated with a cancer, such as non-small-cell lung cancer, in a subject are also disclosed. The methods include (i) administering to the subject the pharmaceutical formulation containing one or more compounds, for one or more times. The compounds can selectively kill cancer cells and/or cancer stem cells over noncancerous cells by inducing mitochondria dysfunction and/or inhibiting ER to Golgi trafficking in the cancer cells and/or cancer stem cells.

专利号:EP-1851227-A1
优先权日:2005-02-25
标题 :An efficient and stereoselective process for large scale synthesis of 3-(r)-3- (2,3-dihydrobenzofuran-5-yl)-1,2,3,4- tetrahydropyrrolo{3,4-b}quinolin-9-one

专利号:US-9868712-B2
优先权日:2013-08-30
标 题 :Synthesis of alkylfurans
发明人：MASCAL MARK; DUTTA SAIKAT
权利人:UNIV CALIFORNIA
摘要:The invention provides a method for preparing a 2,5-dialkyl furan. The method includes forming a reaction mixture containing a catalyst, a hydrogen source, and 2-haloalkylfuran starting material under conditions sufficient to form the 2,5-dialkyl furan. The 2-haloalkylfuran starting material can be derived from biomass, and the 2,5-dialkyl furan product can be used as a biofuel or as a chemical feedstock.