CAS: 611-73-4; 2-Oxo-2-Phenylacetic Acid

上下游产品

CAS号611-71-2 扁桃酸 | CAS号93-56-1 (±)-1-苯基-1,2-乙二醇 | CAS号1603-79-8 苯甲酰甲酸乙酯 | CAS号104-53-0 3-苯丙醛 | CAS号122-78-1 2-苯基乙醛 | CAS号56485-04-2 Benzenepropanal... | CAS号613-90-1 苯甲酰腈 | CAS号1074-12-0 苯基丙醇水合物 | CAS号98-86-2 苯乙酮 | CAS号15206-55-0 苯甲酰甲酸甲酯 | CAS号10549-15-2 α-氧代-N-[(R)-1-苯... | CAS号5424-19-1 3-苯酰基嘧啶 | CAS号3342-78-7 2-氨基苯乙酸 | CAS号3790-45-2 1-苯基-2,3,4,9-四氢... | CAS号3966-30-1 (R)-(-)-2-羟基-2-苯基丙酸 | CAS号103-82-2 苯乙酸 | CAS号60-12-8 苯乙醇 | CAS号611-71-2 扁桃酸 | CAS号93-89-0 苯甲酸乙酯 | CAS号65-85-0 苯甲酸

D-扁桃酸置于d-Lactate Oxidase From Gluconobacter Oxydans 621H,氧气,Catalase体系中,用 Aq. Buffer 作为反应溶剂,化学反应生成 苯甲酰甲酸
参考文献:乳酸氧化酶催化反应对(S)-2-羟基羧酸的酶促分解
标题:乳酸氧化酶催化反应对(S)-2-羟基羧酸的酶促分解
摘要:氧化酶催化的动力学拆分对于生产对映体纯的2-羟基羧酸(2-Has)非常重要,这是合成许多重要化合物的通用构建基块.但是,与(R)-2-Has相比,由于缺乏相关的氧化酶,(S)-2-Ha的生产具有挑战性.在这里,通过分析许多推定的d-乳酸氧化酶序列并鉴定一些所需的特性,系统地筛选了合适的酶.最后,选择氧化葡糖杆菌621H中的d-乳酸氧化酶,具有非常好的溶解度,底物谱宽,立体选择性高等优点,可将2-Has分解为(S)-2-Has.使用该d-乳酸氧化酶成功生产了多种(S)-2-Has,其对映体过量值极佳(> 99%).提出的目标生物催化筛选标准和方法为生产旋光活性化学物质(S)-2-Has提供了指导原则.
DOI:10.1002/cctc.201600536

专利信息

专利号:US-11548898-B2
优先权日:2017-07-06
标题 :Synthesis of halichondrins
发明人：KISHI YOSHITO; AI YANRAN; YE NING; WANG QIAOYI; YAHATA KENZO; ISO Kentaro; NAINI SANTHOSH REDDY; YAMASHITA SHUJI; LEE JIHOON; OHASHI ISAO; FUKUYAMA TAKASHI
权利人:HARVARD COLLEGE; EISAI R&D MAN CO LTD
摘要:The present invention provides methods for the synthesis of ketones involving a Ni/Zr-mediated coupling reaction. The Ni/Zr-mediated ketolization reactions can be used in the synthesis of halichondrins (e.g., halichondrin A, B, C; homohalichondrin A, B, C; norhalichondrin A, B, C), and analogs thereof. Therefore, the present invention also provides synthetic methods useful for the synthesis of halichondrins, and analogs thereof. Also provided herein are compounds (i.e., intermediates) useful in the synthesis of halichondrins, and analogs thereof. In particular, the present invention provides methods and compounds useful in the synthesis of compound of Formula (H3-A).

专利号:US-8153839-B2
优先权日:2005-09-14
标题:Method for synthesis of keto acids or amino acids by hydration of acetylene compound
发明人：OGO SEIJI; FUKUZUMI SHUN-ICHI
权利人:OGO SEIJI; FUKUZUMI SHUN-ICHI; JAPAN SCIENCE & TECH AGENCY
摘要:An object of the present invention is to provide a method for synthesis of keto acids by hydration of an acetylene compound (acetylene-carboxylic acids) under mild conditions free from harmful mercury catalysts and a method for synthesis of amino acids from acetylene-carboxylic acids in a single container (one-pot or tandem synthesis). In one embodiment of the method according to the present invention for synthesis of keto acids, acetylene-carboxylic acids is hydrated in the presence of a metal salt represented by General Formula (1), n nwhere M 1 represents an element in Group VIII, IX, or X of the periodic table, and X 1 , X 2 , or X 3 ligand represents halogen, H 2 O, or a solvent molecule, and k represents a valence of a cation species, and Y represents an anion species, and L represents a valence of the anion species, and each of K and L independently represents 1 or 2, and k×m=L×n.

专利号:US-2004242897-A1
优先权日:2002-07-31
标题 :Universal support media for synthesis of oligomeric compounds
发明人：GUZAEV ANDREI P; MANOHARAN MUTHIAH
摘要:Compounds for the synthesis of oligomeric compounds, particularly oligonucleotides and oligonucleotide mimetics, are provided. In addition, methods for functionalizing a support medium with a first monomeric subunit and methods for the synthesis of oligomeric compounds utilizing the novel compounds bound to support media are provided.

专利号:US-10751419-B2
优先权日:2014-05-01
标题:Method for synthesis of reactive conjugate clusters
发明人：MIGAWA MICHAEL T; YU JINGHUA; WAN W BRAD; PATEL SAYTEN P; VASQUEZ GUILLERMO; KINBERGER GARTH A; PRAKASH THAZHA P; SETH PUNIT P; SWAYZE ERIC E
权利人:IONIS PHARMACEUTICALS INC
摘要:Provided herein are improved methods for the synthesis of reactive conjugate clusters and intermediates used in such methods. In particular, improvements are provided that enhance the synthesis of reactive conjugate clusters by reducing the number of synthetic steps required. The reactive conjugate clusters prepared using the improved methods don't include any transacylation impurities that are formed using existing methods. The improved methods also provide an increase in overall yield and a cost benefit over existing methods.

专利号:US-8293930-B1
优先权日:2004-06-25
标题 :One pot synthesis of taxane derivatives and their conversion to paclitaxel and docetaxel
发明人：NAIDU RAGINA
权利人:NAIDU RAGINA; CHATHAM BIOTEC LTD
摘要:A process is provided for the semi-synthesis of taxane intermediates useful in the preparation of paclitaxel and docetaxel, in particular, the semi-synthesis of protected taxane intermediate in a one pot reaction of protecting the C-7 and C-10 positions and attaching a side chain at the C-13 position and subsequently deprotecting the group to form paclitaxel or docetaxel, and taxane intermediates.

专利号:US-2006287520-A1
优先权日:2005-05-16
标 题 :Synthesis of salinosporamide A and analogues thereof
发明人：DANISHEFSKY SAMUEL J; ENDO ATSUSHI
权利人:DANISHEFSKY SAMUEL J; ENDO ATSUSHI
摘要:A novel synthesis of salinosporamide A is provided. Salinospoamide A as well as structurally related natural products, omuralide and lactacystin, have been shown to be proteasome inhibitors. Therefore, these compounds as well as analogues of these natural products may be useful in the treatment of proliferative diseases such as cancer, autoimmune diseases, diabetic retinopathy, etc. The invention provides for the synthesis of salinosporamide A as well as analogs thereof using a convenient point for derivatization of the bicyclic core. Pharmaceutical compositions and method of using the inventive compounds are also provided.